公开(公告)号：US09035244B2

公开(公告)日：2015-05-19

申请号：US14202531

申请日：2014-03-10

Applicant: 1st Detect Corporation

Inventor： David Rafferty ,  Michael Spencer ,  James Wylde ,  David Lorenz Gardner ,  Warren Mino

IPC: H01J49/38 ,  H01J49/42 ,  H01J49/14 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/147 ,  H01J49/0013 ,  H01J49/0031 ,  H01J49/067 ,  H01J49/424 ,  H01J49/4265

Abstract: A method and apparatus for performing mass spectrometry using an electron source, an ion trap, and a voltage-controlled lens located between the electron source and the ion trap. A controller applies a voltage to the lens. Features of the resulting output spectrum can be analyzed to determine whether to adjust the lens voltage.

Abstract translation: 使用位于电子源和离子阱之间的电子源，离子阱和电压控制透镜进行质谱分析的方法和装置。 控制器向镜头施加电压。 可以分析产生的输出光谱的特征，以确定是否调整透镜电压。

公开(公告)号：US20140252215A1

公开(公告)日：2014-09-11

申请号：US13794779

申请日：2013-03-11

Applicant: 1st Detect Corporation

Inventor： David Rafferty ,  James Wylde ,  Michael Spencer ,  Warren Mino

IPC: H01J49/00

CPC classification number: H01J49/0009

Abstract: Systems and methods are disclosed for calibrating mass spectrometers. In accordance with one implementation, a system comprises a calibrant chamber within a housing of a mass spectrometer. The system also comprises a permeation tube enclosed within the calibrant chamber, wherein the tube contains a calibrant chemical that continuously outgasses the calibrant chemical. The outgassed calibrant chemical may be introduced to the mass spectrometer for analysis. The system may also comprise a heating block to control the temperature of the calibrant chemical. The system may further comprise a valve that introduces a known amount of the calibrant chemical into the calibrant chamber. In accordance with the present disclosure, systems and methods are provided for calibrating a mass spectrometer abundance scale.

Abstract translation: 公开了用于校准质谱仪的系统和方法。 根据一个实施方案，系统包括在质谱仪的壳体内的校准室。 该系统还包括封闭在校准物室内的渗透管，其中管含有连续排出校准物质的校准物质。 可以将去气的校准物质引入质谱仪进行分析。 该系统还可以包括加热块以控制校准物质的温度。 该系统还可以包括将已知量的校准物质引入校准物室的阀。 根据本公开，提供了用于校准质谱仪丰度标度的系统和方法。

公开(公告)号：US08975573B2

公开(公告)日：2015-03-10

申请号：US13794779

申请日：2013-03-11

Applicant: 1st Detect Corporation

Inventor： David Rafferty ,  James Wylde ,  Michael Spencer ,  Warren Mino

IPC: H01J49/00

CPC classification number: H01J49/0009

Abstract: Systems and methods are disclosed for calibrating mass spectrometers. In accordance with one implementation, a system comprises a calibrant chamber within a housing of a mass spectrometer. The system also comprises a permeation tube enclosed within the calibrant chamber, wherein the tube contains a calibrant chemical that continuously outgasses the calibrant chemical. The outgassed calibrant chemical may be introduced to the mass spectrometer for analysis. The system may also comprise a heating block to control the temperature of the calibrant chemical. The system may further comprise a valve that introduces a known amount of the calibrant chemical into the calibrant chamber. In accordance with the present disclosure, systems and methods are provided for calibrating a mass spectrometer abundance scale.

Abstract translation: 公开了用于校准质谱仪的系统和方法。 根据一个实施方案，系统包括在质谱仪的壳体内的校准室。 该系统还包括封闭在校准物室内的渗透管，其中管含有连续排出校准物质的校准物质。 可以将去气的校准物质引入质谱仪进行分析。 该系统还可以包括加热块以控制校准物质的温度。 该系统还可以包括将已知量的校准物质引入校准物室的阀。 根据本公开，提供了用于校准质谱仪丰度标度的系统和方法。

公开(公告)号：US10229824B2

公开(公告)日：2019-03-12

申请号：US13794378

申请日：2013-03-11

Applicant: 1st Detect Corporation

Inventor： Michael Spencer ,  Warren Mino ,  David Rafferty

IPC: G01N30/72 ,  H01J49/24

Abstract: A mass spectrometer for analyzing a sample may include an analysis chamber for analyzing the sample and a first vacuum pump operably connected to the analysis chamber, wherein the first vacuum pump operates to create a first vacuum state. The mass spectrometer may also include a sample-preparation chamber operably connected to the analysis chamber and a second vacuum pump that operates to create a second vacuum state, wherein the first vacuum state is a lower pressure than the second vacuum state. The second vacuum pump may be operably connected to the first vacuum pump in a first configuration, and the second vacuum pump may be operably connected to the sample-preparation chamber in a second configuration.

公开(公告)号：US09299545B2

公开(公告)日：2016-03-29

申请号：US14603017

申请日：2015-01-22

Applicant: 1st DETECT CORPORATION

Inventor： David Rafferty ,  James Wylde ,  Michael Spencer ,  Warren Mino

IPC: H01J49/00

CPC classification number: H01J49/0009

Abstract: Systems and methods are disclosed for calibrating mass spectrometers. In accordance with one implementation, a system comprises a calibrant chamber within a housing of a mass spectrometer. The system also comprises a permeation tube enclosed within the calibrant chamber, wherein the tube contains a calibrant chemical that continuously outgasses the calibrant chemical. The outgassed calibrant chemical may be introduced to the mass spectrometer for analysis. The system may also comprise a heating block to control the temperature of the calibrant chemical. The system may further comprise a valve that introduces a known amount of the calibrant chemical into the calibrant chamber. In accordance with the present disclosure, systems and methods are provided for calibrating a mass spectrometer abundance scale.

公开(公告)号：US20150235826A1

公开(公告)日：2015-08-20

申请号：US14603017

申请日：2015-01-22

Applicant: 1st DETECT CORPORATION

Inventor： David Rafferty ,  James Wylde ,  Michael Spencer ,  Warren Mino

IPC: H01J49/00

CPC classification number: H01J49/0009

Abstract: Systems and methods are disclosed for calibrating mass spectrometers. In accordance with one implementation, a system comprises a calibrant chamber within a housing of a mass spectrometer. The system also comprises a permeation tube enclosed within the calibrant chamber, wherein the tube contains a calibrant chemical that continuously outgasses the calibrant chemical. The outgassed calibrant chemical may be introduced to the mass spectrometer for analysis. The system may also comprise a heating block to control the temperature of the calibrant chemical. The system may further comprise a valve that introduces a known amount of the calibrant chemical into the calibrant chamber. In accordance with the present disclosure, systems and methods are provided for calibrating a mass spectrometer abundance scale.

Abstract translation: 公开了用于校准质谱仪的系统和方法。 根据一个实施方案，系统包括在质谱仪的壳体内的校准室。 该系统还包括封闭在校准物室内的渗透管，其中管含有连续排出校准物质的校准物质。 可以将去气的校准物质引入质谱仪进行分析。 该系统还可以包括加热块以控制校准物质的温度。 该系统还可以包括将已知量的校准物质引入校准物室的阀。 根据本公开，提供了用于校准质谱仪丰度标度的系统和方法。

公开(公告)号：US20140250977A1

公开(公告)日：2014-09-11

申请号：US13794378

申请日：2013-03-11

Applicant: 1ST DETECT CORPORATION

Inventor： Michael Spencer ,  Warren Mino ,  David Rafferty

IPC: G01N30/72

CPC classification number: H01J49/24

Abstract: A mass spectrometer for analyzing a sample may include an analysis chamber for analyzing the sample and a first vacuum pump operably connected to the analysis chamber, wherein the first vacuum pump operates to create a first vacuum state. The mass spectrometer may also include a sample-preparation chamber operably connected to the analysis chamber and a second vacuum pump that operates to create a second vacuum state, wherein the first vacuum state is a lower pressure than the second vacuum state. The second vacuum pump may be operably connected to the first vacuum pump in a first configuration, and the second vacuum pump may be operably connected to the sample-preparation chamber in a second configuration.

Abstract translation: 用于分析样品的质谱仪可以包括用于分析样品的分析室和可操作地连接到分析室的第一真空泵，其中第一真空泵操作以产生第一真空状态。 质谱仪还可以包括可操作地连接到分析室的样品制备室和用于产生第二真空状态的第二真空泵，其中第一真空状态是比第二真空状态低的压力。 第二真空泵可以以第一配置可操作地连接到第一真空泵，并且第二真空泵可以以第二配置可操作地连接到样品制备室。