公开(公告)号：US10562997B2

公开(公告)日：2020-02-18

申请号：US15549268

申请日：2016-03-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Andrew W. Vail ,  Jerald K. Rasmussen ,  John J. Schmidt ,  Ali E. Ozcam ,  Jonathan F. Hester ,  Gregory M. Jellum

IPC: C12N15/10 ,  C12Q1/6806 ,  C08F255/02 ,  G01N1/40

Abstract: A method of purifying a biological composition includes: disposing loose cationic ligand-functionalized staple fibers and a biological composition within a mixing volume of a vessel; agitating the biological composition and the loose cationic ligand-functionalized staple fibers while they are in intimate contact with each other within the mixing volume to provide modified fibers and a purified biological composition; and separating at least a portion of the purified biological composition from the modified fibers and any loose cationic ligand-functionalized staple fibers with which it is in contact. The loose cationic ligand-functionalized staple fibers have a modified surface layer comprising a grafted acrylic polymer comprising 10 to 100 percent by weight of a cationically-ionizable monomer unit. An article for purifying a biological composition includes: a vessel having a mixing volume disposed therein; and the loose cationic ligand-functionalized staple fibers disposed within the mixing volume.

公开(公告)号：US20180257042A1

公开(公告)日：2018-09-13

申请号：US15755584

申请日：2016-10-11

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Jonathan F. Hester ,  Angelines A. Castro Forero ,  Gregory M. Jellum ,  Jerald K. Rasmussen ,  Kannan Seshadri ,  Clinton P. Waller, Jr.

IPC: B01D69/12 ,  B01D71/40 ,  B01D71/78 ,  B01D63/14 ,  B01D63/10 ,  B01D67/00 ,  B01D69/02 ,  C07K1/34

Abstract: Described herein is a filtration media comprising: (i) a first filtration medium comprising an anion exchange nonwoven substrate, wherein the anion exchange nonwoven substrate comprises a plurality of quaternary ammonium groups; and (ii) a second filtration medium comprising a functionalized microporous membrane wherein the functionalized microporous membrane comprises a plurality of guanidyl groups; wherein the first filtration medium is positioned upstream of the second filtration medium.

公开(公告)号：US20180066095A1

公开(公告)日：2018-03-08

申请号：US15549268

申请日：2016-03-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Andrew W. Vail ,  Jerald K. Rasmussen ,  John J. Schmidt ,  Ali E. Ozcam ,  Jonathan F. Hester ,  Gregory M. Jellum

IPC: C08F255/02 ,  G01N1/40 ,  C12Q1/68 ,  C12N15/10

CPC classification number: C08F255/02 ,  C08F220/00 ,  C12N15/101 ,  C12N15/1017 ,  C12Q1/6806 ,  D06M14/28 ,  D06M15/263 ,  D06M15/267 ,  D06M15/273 ,  D06M15/3562 ,  G01N1/4077 ,  G01N2001/4088

Abstract: A method of purifying a biological composition includes: disposing loose cationic ligand-functionalized staple fibers and a biological composition within a mixing volume of a vessel; agitating the biological composition and the loose cationic ligand-functionalized staple fibers while they are in intimate contact with each other within the mixing volume to provide modified fibers and a purified biological composition; and separating at least a portion of the purified biological composition from the modified fibers and any loose cationic ligand-functionalized staple fibers with which it is in contact. The loose cationic ligand-functionalized staple fibers have a modified surface layer comprising a grafted acrylic polymer comprising 10 to 100 percent by weight of a cationically-ionizable monomer unit. An article for purifying a biological composition includes: a vessel having a mixing volume disposed therein; and the loose cationic ligand-functionalized staple fibers disposed within the mixing volume.

公开(公告)号：US10722848B2

公开(公告)日：2020-07-28

申请号：US15755584

申请日：2016-10-11

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Jonathan F. Hester ,  Angelines A. Castro Forero ,  Gregory M. Jellum ,  Jerald K. Rasmussen ,  Kannan Seshadri ,  Clinton P. Waller, Jr.

IPC: B01D69/12 ,  B01D67/00 ,  B01D71/40 ,  B01D71/78 ,  B01D69/10 ,  B01D63/10 ,  B01D63/14 ,  B01D69/02 ,  C07K1/34

Abstract: Described herein is a filtration media comprising: (i) a first filtration medium comprising an anion exchange nonwoven substrate, wherein the anion exchange nonwoven substrate comprises a plurality of quaternary ammonium groups; and (ii) a second filtration medium comprising a functionalized microporous membrane wherein the functionalized microporous membrane comprises a plurality of guanidyl groups; wherein the first filtration medium is positioned upstream of the second filtration medium.

公开(公告)号：US20150273405A1

公开(公告)日：2015-10-01

申请号：US14428831

申请日：2013-09-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： John W. Henderson ,  Brady P. Haislet ,  Brent R. Hansen ,  Jonathan F. Hester ,  Gregory M. Jellum ,  Qihong Nie ,  John F. Reed ,  John B. Scheibner ,  David F. Slama ,  Steven E. Turch

IPC: B01D71/68 ,  B01D19/00 ,  B01D67/00 ,  B01D71/10 ,  B01D71/34 ,  B01D71/58 ,  B01D71/50 ,  B01D71/26 ,  B01D71/38 ,  B01D71/32 ,  B01D53/22 ,  B01D71/56

CPC classification number: B01D71/68 ,  B01D19/0031 ,  B01D53/228 ,  B01D61/08 ,  B01D61/18 ,  B01D63/082 ,  B01D65/003 ,  B01D67/0002 ,  B01D71/10 ,  B01D71/26 ,  B01D71/32 ,  B01D71/34 ,  B01D71/38 ,  B01D71/50 ,  B01D71/56 ,  B01D71/58 ,  B01D2053/221 ,  B01D2313/08 ,  B01D2313/14

Abstract: Described herein is a membrane separation module and articles and methods thereof, wherein the membrane separation module has a series of repeating layers, each layer comprising (a) a selectively permeable membrane; and (b) at least one support layer, wherein the support layer comprises a plurality of flow channels and a plurality of rails extending from the support layer, wherein the sides of two adjacent rails form a flow channel, wherein the plurality of rails on the support layer comprise a thermoplastic polymer at the distal end of at least a portion of the plurality of rails, and wherein the distal end of the plurality of rails contacts the selectively permeable membrane to form a bonded stack.

Abstract translation: 本文描述的是膜分离模块及其制品和方法，其中膜分离模块具有一系列重复层，每层包括（a）选择性渗透膜; 和（b）至少一个支撑层，其中所述支撑层包括多个流动通道和从所述支撑层延伸的多个轨道，其中两个相邻导轨的侧面形成流动通道，其中所述多个轨道 支撑层在多个轨道的至少一部分的远端处包括热塑性聚合物，并且其中多个轨道的远端接触选择性渗透膜以形成键合叠层。