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    DEVICES AND METHODS FOR SAMPLE PARTITIONING AND ANALYSIS
    1.
    发明申请
    DEVICES AND METHODS FOR SAMPLE PARTITIONING AND ANALYSIS 审中-公开

    公开(公告)号：US20170240949A1

    公开(公告)日：2017-08-24

    申请号：US15503496

    申请日：2015-08-19

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： EVAN D. BRUTINEL ,  KURT J. HALVERSON

    IPC: C12Q1/06 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34

    CPC classification number: C12Q1/06 ,  C12M23/34 ,  C12M23/38 ,  C12M25/06 ,  C12M37/04 ,  C12M41/36 ,  C12Q1/04

    Abstract: The present disclosure provides a device that includes a base comprising a substrate having a first major surface, a pressure sensitive adhesive adhered to at least a portion of the first major surface, a polymeric cover film coupled to the substrate via the adhesive, a plurality of isolated closed compartments disposed between the substrate and the cover film, and an aqueous liquid disposed in two or more of the closed compartments. The cover film is a composite film comprising ethylene vinyl acetate copolymer, a linear copolymer of ethylene and a higher alkene, and a tackifier. Each compartment of the plurality is defined by a seal that prevents liquid communication with at least one other compartment of the plurality. Methods of using the device for partitioning a sample, for analyzing a sample, and for culturing a microorganism are also provided.

    SAMPLING DEVICES AND METHODS FOR CONCENTRATING MICROORGANISMS
    3.
    发明申请
    SAMPLING DEVICES AND METHODS FOR CONCENTRATING MICROORGANISMS 审中-公开
    采样装置和浓缩微生物的方法

    公开(公告)号：US20160215325A1

    公开(公告)日：2016-07-28

    申请号：US15091024

    申请日：2016-04-05

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： MANJIRI T. KSHIRSAGAR ,  KURT J. HALVERSON ,  NEIL PERCY ,  JAMES E. AYSTA

    IPC: C12Q1/24 ,  C12M1/00 ,  G01N1/40

    CPC classification number: C12Q1/24 ,  C12M47/02 ,  C12M47/04 ,  G01N1/40 ,  G01N1/405 ,  G01N2001/4088

    Abstract: The present disclosure describes methods for concentrating microorganisms with concentration agents in a sampling device and the sampling device described herein. More specifically, methods for concentrating microorganisms from large volume samples with concentration agents in a sampling device can provide for rapid, low cost, simple (involving no complex equipment or procedures), and/or effective processes under a variety of conditions.

    Abstract translation: 本公开描述了将浓缩剂浓缩在采样装置中的微生物和本文所述的采样装置的方法。 更具体地说，用于将来自大容量样品的微生物浓缩在采样装置中的浓缩剂的方法可以在各种条件下提供快速，低成本，简单（不涉及复杂的设备或程序）和/或有效过程。

    CULTURE DEVICE AND METHODS FOR ENUMERATING MOLD COLONIES
    4.
    发明申请
    CULTURE DEVICE AND METHODS FOR ENUMERATING MOLD COLONIES 审中-公开

    公开(公告)号：US20190085282A1

    公开(公告)日：2019-03-21

    申请号：US16196564

    申请日：2018-11-20

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： KURT J. HALVERSON

    IPC: C12M1/34 ,  C12Q1/06 ,  C12M1/12 ,  C12Q1/04 ,  C12M1/00 ,  C12M1/04 ,  C12M3/00

    Abstract: A thin film culture device for enumerating mold colonies is provided. The device comprises water-resistant first and second substrates with a growth region disposed therebetween, a dry, cold water-soluble gelling agent disposed in the growth region, and an effective amount of a calcium-chelating compound disposed in the growth region. The effective amount of calcium-chelating compound is capable of reducing a rate of lateral enlargement of the colony-forming unit growing in the culture device relative to the rate of lateral enlargement of a colony of the same mold species growing in an otherwise identical culture device that does not contain the effective amount disposed in the growth region, wherein reducing the rate of lateral enlargement of the colony-forming unit does not substantially delay detection of the colony. A corresponding method is also provided.

    BIOLOGICAL STERILIZATION INDICATOR DEVICES AND METHODS OF USE
    5.
    发明申请
    BIOLOGICAL STERILIZATION INDICATOR DEVICES AND METHODS OF USE 审中-公开
    生物灭菌指示剂装置及其使用方法

    公开(公告)号：US20150337354A1

    公开(公告)日：2015-11-26

    申请号：US14377203

    申请日：2013-02-11

    Applicant: Francois AHIMOU ,  Sailaja CHANDRAPATI ,  Kurt J. HALVERSON ,  Heather M. WEBB ,  Michael G. WILLIAMS ,  3M INNOVATIVE PROPERTIES COMPANY

    Inventor： FRANCOIS AHIMOU ,  SAILAJA CHANDRAPATI ,  KURT J. HALVERSON ,  HEATHER M. WEBB ,  MICHAEL G. WILLIAMS

    IPC: C12Q1/22 ,  G01N21/64

    CPC classification number: C12Q1/22 ,  G01N21/6428 ,  G01N2201/061

    Abstract: A biological sterilization indicator device is provided. The device comprises a body, a plurality of test microorganisms, and an oxygen-modulated first fluorescent sensor. The body comprises a first layer attached to a second layer, forming at least one isolatable microchamber and at least one primary passageway that provides fluidic communication between ambience and the at least one microchamber. The microchamber has an isolated volume of about 0.5 microliters to about 9.5 microliters. The plurality of test microorganisms and the oxygen-modulated first fluorescent sensor are disposed in the microchamber. A method of using the device to determine the effectiveness of a sterilization process is also provided.

    Abstract translation: 提供生物灭菌指示装置。 该装置包括主体，多个测试微生物和氧调制的第一荧光传感器。 主体包括附接到第二层的第一层，形成至少一个可隔离的微室和至少一个主通道，其提供环境与至少一个微室之间的流体连通。 微室具有约0.5微升至约9.5微升的隔离体积。 多个测试微生物和氧调制的第一荧光传感器设置在微室中。 还提供了使用该装置来确定灭菌过程的有效性的方法。

    BIOLOGICAL COMPOSITIONS, ARTICLES AND METHODS FOR MONITORING STERILIZATION PROCESSES
    7.
    发明申请
    BIOLOGICAL COMPOSITIONS, ARTICLES AND METHODS FOR MONITORING STERILIZATION PROCESSES 审中-公开
    生物组合物，用于监测灭菌过程的文章和方法

    公开(公告)号：US20170037447A1

    公开(公告)日：2017-02-09

    申请号：US15332331

    申请日：2016-10-24

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： SAILAJA CHANDRAPATI ,  HEATHER M. WEBB ,  KURT J. HALVERSON

    IPC: C12Q1/22

    CPC classification number: C12Q1/22

    Abstract: A sterility indicating composition comprising a plurality of sterilization process resistant spores; a germination medium comprising a sub-lethal amount of at least one cell-permeant nucleic acid-interacting fluorescent dye and at least one nutrient for germination of the spores; wherein the at least one cell-permeant fluorescent dye can interact with nucleic acids present in and produced by the plurality of spores during germination or during germination and outgrowth of the spores to produce an increase in fluorescence intensity, indicating that viable spores are present, and wherein the cell-permeant fluorescent dye is sufficiently stable at least at a temperature for incubating the spores to produce the increase in fluorescence intensity, a sterilization process indicator comprising the composition, and a method of determining the effectiveness of a sterilization process using the composition and indicator are disclosed.

    Abstract translation: 一种无菌指示组合物，其包含多个耐灭菌过程的孢子; 包含亚致死量的至少一种细胞渗透性核酸相互作用荧光染料和至少一种用于孢子发芽的营养物的发芽培养基; 其中所述至少一种细胞透过性荧光染料可以在发芽过程中或在芽孢的发芽和生长期间与存在于和由多个孢子产生的核酸相互作用以产生荧光强度的增加，从而表明存在可行的孢子，以及 其中所述细胞透过性荧光染料至少在用于培养孢子以产生荧光强度增加的温度下是足够稳定的，包含该组合物的灭菌过程指示剂以及使用该组合物确定灭菌过程的有效性的方法，以及 指标。

    CULTURE DEVICE AND METHODS FOR ENUMERATING MOLD COLONIES
    9.
    发明申请
    CULTURE DEVICE AND METHODS FOR ENUMERATING MOLD COLONIES 审中-公开
    文化装置和用于铸造模具的方法

    公开(公告)号：US20160075988A1

    公开(公告)日：2016-03-17

    申请号：US14889054

    申请日：2014-05-05

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： KURT J. HALVERSON

    IPC: C12M1/34 ,  C12M1/04 ,  C12Q1/06 ,  C12M1/00

    CPC classification number: C12M41/36 ,  C12M23/04 ,  C12M23/20 ,  C12M23/22 ,  C12M23/24 ,  C12M23/28 ,  C12M23/48 ,  C12M25/02 ,  C12M25/06 ,  C12Q1/045 ,  C12Q1/06

    Abstract: A thin film culture device for enumerating mold colonies is provided. The device comprises water-resistant first and second substrates with a growth region disposed therebetween, a dry, cold water-soluble gelling agent disposed in the growth region, and an effective amount of a calcium-chelating compound disposed in the growth region. The effective amount of calcium-chelating compound is capable of reducing a rate of lateral enlargement of the colony-forming unit growing in the culture device relative to the rate of lateral enlargement of a colony of the same mold species growing in an otherwise identical culture device that does not contain the effective amount disposed in the growth region, wherein reducing the rate of lateral enlargement of the colony-forming unit does not substantially delay detection of the colony. A corresponding method is also provided.

    Abstract translation: 提供了一种用于枚举模具菌落的薄膜培养装置。 该装置包括其间具有生长区域的防水第一和第二基底，设置在生长区域中的干燥的冷水溶性胶凝剂和有效量的配置在生长区域中的钙螯合化合物。 钙螯合化合物的有效量能够降低培养装置中生长的集落形成单位的横向扩大率相对于在相同的培养装置中生长的相同模具种类的菌落的侧向扩大的速率 其不包含设置在生长区域中的有效量，其中降低菌落形成单元的横向扩大率基本上不延迟菌落的检测。 还提供了相应的方法。

    MICROBIAL DETECTION SYSTEM AND METHODS
    10.
    发明申请
    MICROBIAL DETECTION SYSTEM AND METHODS 审中-公开
    微生物检测系统及方法

    公开(公告)号：US20150344931A1

    公开(公告)日：2015-12-03

    申请号：US14824618

    申请日：2015-08-12

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： PHILLIP A. BOLEA ,  KURT J. HALVERSON ,  CYNTHIA D. ZOOK

    IPC: C12Q1/04

    CPC classification number: C12Q1/04 ,  C12M23/04 ,  C12M25/14 ,  C12M41/36 ,  C12Q1/24

    Abstract: The disclosure provides culture devices and methods for a microorganism in a sample. The devices include a base member, a cover sheet, an adhesive layer coupled to the base member or the cover sheet, and a cold water-soluble gelling agent disposed on the base member; wherein the devices are substantially optically transmissive when the gelling agent is hydrated with a clear liquid. Methods of use include detecting or enumerating microorganisms. The methods further provide for detecting a microorganism by detecting the presence or size of an abiogenic gas bubble in a culture device.

    Abstract translation: 本公开提供了样品中微生物的培养装置和方法。 这些装置包括基底部件，覆盖片，连接到基底部件或覆盖片的粘合剂层，以及设置在基底部件上的冷水溶性胶凝剂; 其中当胶凝剂与透明液体水合时，所述装置基本上是光学透射的。 使用方法包括检测或列举微生物。 该方法进一步提供了通过检测培养装置中的生物气泡的存在或大小来检测微生物。

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