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1.发明申请METHODS FOR MODULATING PROTEIN GLYCOSYLATION PROFILES OF RECOMBINANT PROTEIN THERAPEUTICS USING MONOSACCHARIDES AND OLIGOSACCHARIDES 有权使用单加糖和低聚糖调节重组蛋白质治疗药物蛋白质糖蛋白的方法公开(公告)号：US20140271632A1
公开(公告)日：2014-09-18
申请号：US14209821
申请日：2014-03-13
Applicant: AbbVie, Inc.
Inventor： Patrick Hossler , Sean McDermott , Christopher Racicot , Ivan Correia
IPC: C07K16/24
CPC classification number: C12P21/005 , C07K16/00 , C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/60 , C07K2317/732 , C12N5/0018 , C12N2500/34
Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.
Abstract translation: 本发明涉及蛋白质生产领域，特别涉及调节在宿主细胞中表达的蛋白质糖基化的方法和组合物。
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公开(公告)号：US20190185897A1
公开(公告)日：2019-06-20
申请号：US16042037
申请日：2018-07-23
Applicant: AbbVie Inc.
Inventor： Patrick Hossler , Sean McDermott , Christopher Racicot , Ivan Correia
CPC classification number: C12P21/005 , C07K16/00 , C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/60 , C07K2317/732 , C12N5/0018 , C12N2500/34
Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.
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3.发明申请公开(公告)号：US20170226552A1
公开(公告)日：2017-08-10
申请号：US15320522
申请日：2015-07-01
Applicant: AbbVie Inc.
Inventor： Patrick Hossler , Christopher Racicot , Sean McDermott
CPC classification number: C12P21/005 , C07K16/00 , C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/64 , C12N1/38 , C12P21/00
Abstract: The present invention relates to the field of protein production and, in particular, to methods and compositions for modulating the glycosylation of recombinant proteins expressed in host cells using cell culture media supplemented with cobalt.
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公开(公告)号：US09416181B2
公开(公告)日：2016-08-16
申请号：US14270675
申请日：2014-05-06
Applicant: AbbVie Inc.
Inventor： Min Wang , Patrick M. Hossler , Sean W. McDermott , Christopher Racicot , Kofi Chemfe , John Fann
IPC: C12N5/00 , C07K16/24 , A61K39/395 , C07K16/00
CPC classification number: C07K16/241 , A61K39/39591 , C07K16/00 , C07K2317/14 , C12N5/0043 , C12N5/005 , C12N2501/999 , C12N2510/02
Abstract: Supplementation of the bioflavonoids such as epigallocatechin gallate, rutin, naringin, or genistein into mammalian cell culture media are shown to be effective in reduction of acidic species variants on recombinant antibodies. The demonstrated reduction in acidic species through the use of bioflavonoids, facilitates the manufacturing of a less heterogeneous product with potential improvements in antibody structure and function.
Abstract translation: 显示在哺乳动物细胞培养基中补充生物类黄酮如表没食子儿茶素没食子酸酯，芦丁，柚皮苷或染料木素可有效减少重组抗体上的酸性物种变体。 通过使用生物类黄酮证明酸性物质的减少有利于制造具有潜在改进抗体结构和功能的较不均匀的产品。
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Patent Agency Ranking
公开(公告)号：US20170355760A1
公开(公告)日：2017-12-14
申请号：US15588211
申请日：2017-05-05
Applicant: AbbVie Inc.
Inventor： Patrick Hossler , Sean McDermott , Christopher Racicot , Joseph G. Matuck , Keith Cochran , Christopher M. Chumsae
CPC classification number: C07K16/241 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C12N5/0037 , C12N2500/34 , C12N2510/02 , C12P21/005
Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant proteins expressed in host cells.
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公开(公告)号：US20170137860A1
公开(公告)日：2017-05-18
申请号：US15343549
申请日：2016-11-04
Applicant: AbbVie Inc.
Inventor： Patrick Hossler , Sean McDermott , Christopher Racicot , Ivan Correia
CPC classification number: C12P21/005 , C07K16/00 , C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/60 , C07K2317/732 , C12N5/0018 , C12N2500/34
Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.
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7.发明授权公开(公告)号：US09499614B2
公开(公告)日：2016-11-22
申请号：US14209821
申请日：2014-03-13
Applicant: AbbVie, Inc.
Inventor： Patrick Hossler , Sean McDermott , Christopher Racicot , Ivan Correia
CPC classification number: C12P21/005 , C07K16/00 , C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/60 , C07K2317/732 , C12N5/0018 , C12N2500/34
Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.
Abstract translation: 本发明涉及蛋白质生产领域，特别涉及调节在宿主细胞中表达的蛋白质糖基化的方法和组合物。
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8.发明申请METHODS FOR MODULATING THE GLYCOSYLATION PROFILE OF RECOMBINANT PROTEINS USING SUGARS 审中-公开使用蔗糖调节重组蛋白质糖化曲线的方法公开(公告)号：US20160185848A1
公开(公告)日：2016-06-30
申请号：US14795838
申请日：2015-07-09
Applicant: ABBVIE INC.
Inventor： Patrick Hossler , Sean McDermott , Christopher Racicot , Joseph G. Matuck , Keith Cochran , Chris M. Chumsae
CPC classification number: C07K16/241 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C12N5/0037 , C12N2500/34 , C12N2510/02 , C12P21/005
Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant proteins expressed in host cells.
Abstract translation: 本发明涉及蛋白质生产领域，特别涉及用于调节在宿主细胞中表达的重组蛋白质糖基化的方法和组合物。
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公开(公告)号：US20140329279A1
公开(公告)日：2014-11-06
申请号：US14270675
申请日：2014-05-06
Applicant: AbbVie Inc.
Inventor： Min Wang , Patrick M. Hossler , Sean W. McDermott , Christopher Racicot , Kofi Chemfe , John Fann
CPC classification number: C07K16/241 , A61K39/39591 , C07K16/00 , C07K2317/14 , C12N5/0043 , C12N5/005 , C12N2501/999 , C12N2510/02
Abstract: Supplementation of the bioflavonoids such as epigallocatechin gallate, rutin, naringin, or genistein into mammalian cell culture media are shown to be effective in reduction of acidic species variants on recombinant antibodies. The demonstrated reduction in acidic species through the use of bioflavonoids, facilitates the manufacturing of a less heterogeneous product with potential improvements in antibody structure and function.
Abstract translation: 显示在哺乳动物细胞培养基中补充生物类黄酮如表没食子儿茶素没食子酸酯，芦丁，柚皮苷或染料木素可有效减少重组抗体上的酸性物种变体。 通过使用生物类黄酮证明酸性物质的减少有利于制造具有潜在改进抗体结构和功能的较不均匀的产品。
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