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1.发明授权公开(公告)号：US09193787B2
公开(公告)日：2015-11-24
申请号：US14522535
申请日：2014-10-23
Applicant: ABBVIE INC.
Inventor： Christopher M. Chumsae
CPC classification number: C07K16/241 , B01D15/362 , C07K1/18 , C07K2317/21 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N30/96
Abstract: Methylglyoxal (MGO)-modified recombinant TNF-alpha antibodies (e.g., Adalimumab) are identified. MGO modification decreases binding between Adalimumab and TNF-alpha. Methods are disclosed for reducing the presence of MGO-modified antibodies in the production of Adalimumab TNF-alpha antibodies.
Abstract translation: 鉴定了甲基乙二醛（MGO）修饰的重组TNF-α抗体（例如阿达木单抗）。 MGO修饰降低阿达木单抗与TNF-α之间的结合。 公开了用于在产生阿达木单抗TNF-α抗体中减少MGO修饰的抗体的存在的方法。
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公开(公告)号：US20170349655A1
公开(公告)日：2017-12-07
申请号：US15626637
申请日：2017-06-19
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Mayda Perez Thiele , Xiaobei Zeng , Chee Furng Wong , Christopher M. Chumsae
CPC classification number: C07K16/241 , C07K16/00 , C07K16/2803 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/526 , C12N5/0018 , C12N2500/22 , C12N2500/32 , C12N2511/00 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.
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公开(公告)号：US09708400B2
公开(公告)日：2017-07-18
申请号：US14923958
申请日：2015-10-27
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Mayda Perez Thiele , Xiaobei Zeng , Chee Furng Wong , Christopher M. Chumsae
CPC classification number: C07K16/241 , C07K16/00 , C07K16/2803 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/526 , C12N5/0018 , C12N2500/22 , C12N2500/32 , C12N2511/00 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.
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4.发明授权公开(公告)号：US09499616B2
公开(公告)日：2016-11-22
申请号：US14923966
申请日：2015-10-27
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Mayda Perez Thiele , Xiaobei Zeng , Chee Furng Wong , Zehra Kaymakcalan , Ying Jing , Christopher M. Chumsae
CPC classification number: C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C12P21/005
Abstract: The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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Patent Agency Ranking
5.发明申请Methods of Reducing Methylglyoxal (MGO) Modification of Recombinant Proteins in Cell Culture 审中-公开减少甲基乙二醛（MGO）细胞培养重组蛋白修饰的方法公开(公告)号：US20160115225A1
公开(公告)日：2016-04-28
申请号：US14922088
申请日：2015-10-23
Applicant: AbbVie Inc.
Inventor： Christopher M. Chumsae , Kartik Subramanian , Yun ("Frank") Zhang
IPC: C07K16/24
CPC classification number: C07K16/241 , C07K2317/14
Abstract: Methods are provided for controlling the levels of acidic species when a protein of interest is expressed by host cells. One particular example of an acidic species is methylglyoxal (MGO). Reduction of acidic species such as MGO may be achieved by regulating the glucose consumption of the cell culture or by modulating the cysteine/glutathione metabolic pathways.
Abstract translation: 当由宿主细胞表达感兴趣的蛋白质时，提供了控制酸性物质水平的方法。 酸性物质的一个具体实例是甲基乙二醛（MGO）。 通过调节细胞培养物的葡萄糖消耗或通过调节半胱氨酸/谷胱甘肽代谢途径，可以实现诸如MGO的酸性物质的还原。
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公开(公告)号：US20170355760A1
公开(公告)日：2017-12-14
申请号：US15588211
申请日：2017-05-05
Applicant: AbbVie Inc.
Inventor： Patrick Hossler , Sean McDermott , Christopher Racicot , Joseph G. Matuck , Keith Cochran , Christopher M. Chumsae
CPC classification number: C07K16/241 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C12N5/0037 , C12N2500/34 , C12N2510/02 , C12P21/005
Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant proteins expressed in host cells.
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7.发明授权公开(公告)号：US09505833B2
公开(公告)日：2016-11-29
申请号：US14078181
申请日：2013-11-12
Applicant: ABBVIE INC.
Inventor： Christopher M. Chumsae
CPC classification number: C07K16/241 , B01D15/362 , C07K1/18 , C07K2317/21 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N30/96
Abstract: Methylglyoxal (MGO)-modified recombinant TNF-alpha antibodies (e.g., Adalimumab) are identified. MGO modification decreases binding between Adalimumab and TNF-alpha. Methods are disclosed for reducing the presence of MOO-modified antibodies in the production of Adalimumab TNF-alpha antibodies.
Abstract translation: 鉴定了甲基乙二醛（MGO）修饰的重组TNF-α抗体（例如阿达木单抗）。 MGO修饰降低阿达木单抗与TNF-α之间的结合。 公开了用于在产生阿达木单抗TNF-α抗体中减少MOO-修饰的抗体的存在的方法。
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8.发明申请公开(公告)号：US20160237150A1
公开(公告)日：2016-08-18
申请号：US14923966
申请日：2015-10-27
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Mayda Perez Thiele , Xiaobei Zeng , Chee Furng Wong , Zehra Kaymakcalan , Ying Jing , Christopher M. Chumsae
CPC classification number: C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C12P21/005
Abstract: The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US20160046708A1
公开(公告)日：2016-02-18
申请号：US14923958
申请日：2015-10-27
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Mayda Perez Thiele , Xiaobei Zeng , Chee Furng Wong , Christopher M. Chumsae
IPC: C07K16/24
CPC classification number: C07K16/241 , C07K16/00 , C07K16/2803 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/526 , C12N5/0018 , C12N2500/22 , C12N2500/32 , C12N2511/00 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.
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