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1.发明授权公开(公告)号：US09200069B2
公开(公告)日：2015-12-01
申请号：US14614311
申请日：2015-02-04
Applicant: AbbVie, Inc.
Inventor： Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
Abstract translation: 本发明涉及包含蛋白质例如抗体或其抗原结合部分的低酸性物质（AR）组合物，以及用于生产这种低AR组合物的方法，例如细胞培养和/或蛋白质纯化方法。 还提供了使用这种组合物治疗病症（例如其中TNFα有害的病症）的方法。
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公开(公告)号：US09150645B2
公开(公告)日：2015-10-06
申请号：US13830583
申请日：2013-03-14
Applicant: ABBVIE INC.
Inventor： Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Christopher Chumsae
CPC classification number: C07K16/241 , A61K39/39591 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/00 , C07K2317/14 , C07K2317/21 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
Abstract translation: 本发明涉及蛋白质生产和纯化领域，特别涉及用于控制由宿主细胞表达的酸性物质的量的组合物和方法，以及用于控制纯化制剂中存在的酸性物质的量的组合物和方法 。
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公开(公告)号：US20150140006A1
公开(公告)日：2015-05-21
申请号：US14614311
申请日：2015-02-04
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US20160264617A1
公开(公告)日：2016-09-15
申请号：US14883195
申请日：2015-10-14
Applicant: AbbVie Inc.
Inventor： Diane D. Dong , Stephen M. Lu , Natarajan Ramasubramanyan , Wen-Chung Lim
CPC classification number: C07K1/18 , A61K39/39591 , B01D15/363 , B01D15/426 , C07K1/165 , C07K1/36 , C07K16/00 , C07K16/18 , C07K2317/10
Abstract: Disclosed herein is an integrated approach to purification process development and execution, including processes comprising particular capture and fine purification steps; processes that employ of a minimal number of buffer systems, and processes that make use of minimally-corrosive buffer systems, as well as combinations thereof.
Abstract translation: 本文公开了一种净化方法开发和执行的综合方法，包括包含特定捕获和精制纯化步骤的方法; 使用最少数量的缓冲系统的过程，以及利用最小腐蚀性缓冲系统的过程，以及其组合。
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公开(公告)号：US09315574B2
公开(公告)日：2016-04-19
申请号：US14584619
申请日：2014-12-29
Applicant: AbbVie, Inc.
Inventor： Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
IPC: C07K14/525 , A61K39/395 , C07K16/24 , C07K16/00 , A61K39/00
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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Patent Agency Ranking
公开(公告)号：US09683033B2
公开(公告)日：2017-06-20
申请号：US15008895
申请日：2016-01-28
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Christopher Chumsae
IPC: C07K16/00 , C07K1/00 , C07K16/24 , C07K1/16 , C07K1/18 , A61K39/395 , C12P21/00 , C07K1/20 , C07K1/22
CPC classification number: C07K16/241 , A61K39/39591 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/00 , C07K2317/14 , C07K2317/21 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
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公开(公告)号：US09522953B2
公开(公告)日：2016-12-20
申请号：US15009286
申请日：2016-01-28
Applicant: AbbVie, Inc.
Inventor： Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US09359434B2
公开(公告)日：2016-06-07
申请号：US14842933
申请日：2015-09-02
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Christopher Chumsae
IPC: C07K1/18 , C07K16/00 , A61K39/00 , C12P21/00 , C07K16/24 , C07K1/16 , A61K39/395 , C07K1/20 , C07K1/22
CPC classification number: C07K16/241 , A61K39/39591 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/00 , C07K2317/14 , C07K2317/21 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
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公开(公告)号：US09266949B2
公开(公告)日：2016-02-23
申请号：US14575691
申请日：2014-12-18
Applicant: AbbVie, Inc.
Inventor： Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US09200070B2
公开(公告)日：2015-12-01
申请号：US14714113
申请日：2015-05-15
Applicant: AbbVie, Inc.
Inventor： Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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