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公开(公告)号：US09266949B2
公开(公告)日：2016-02-23
申请号：US14575691
申请日：2014-12-18
Applicant: AbbVie, Inc.
Inventor： Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US09200070B2
公开(公告)日：2015-12-01
申请号：US14714113
申请日：2015-05-15
Applicant: AbbVie, Inc.
Inventor： Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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3.发明授权Modulated lysine variant species compositions and methods for producing and using the same 有权调节的赖氨酸变种种组合物及其制备和使用方法公开(公告)号：US09181337B2
公开(公告)日：2015-11-10
申请号：US14077988
申请日：2013-11-12
Applicant: AbbVie, Inc.
Inventor： Kartik Subramanian , Mayda Perez Thiele , Xiaobei Zeng , Chee Furng Wong , Zehra Kaymakcalan , Ying Jing , Christopher Chumsae
IPC: A61K39/395 , C07K16/24
CPC classification number: C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C12P21/005
Abstract: The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
Abstract translation: 本发明涉及包含蛋白质例如抗体或其抗原结合部分的调节的赖氨酸变体种组合物，以及用于产生这种经调节的赖氨酸变体种组合物的方法，例如细胞培养和/或蛋白质纯化方法。 还提供了使用这种组合物治疗病症（例如其中TNFα有害的病症）的方法。
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公开(公告)号：US20140161815A9
公开(公告)日：2014-06-12
申请号：US13830583
申请日：2013-03-14
Applicant: ABBVIE INC.
Inventor： Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chen Lim , Kathreen A. Gifford
IPC: C12P21/00
CPC classification number: C07K16/241 , A61K39/39591 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/00 , C07K2317/14 , C07K2317/21 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
Abstract translation: 本发明涉及蛋白质生产和纯化领域，特别涉及用于控制由宿主细胞表达的酸性物质的量的组合物和方法，以及用于控制纯化制剂中存在的酸性物质的量的组合物和方法 。
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公开(公告)号：US20130344084A1
公开(公告)日：2013-12-26
申请号：US13830583
申请日：2013-03-14
Applicant: ABBVIE INC.
Inventor： Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chen Lim , Kathreen A. Gifford
IPC: C12P21/00
CPC classification number: C07K16/241 , A61K39/39591 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/00 , C07K2317/14 , C07K2317/21 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
Abstract translation: 本发明涉及蛋白质生产和纯化领域，特别涉及用于控制由宿主细胞表达的酸性物质的量的组合物和方法，以及用于控制纯化制剂中存在的酸性物质的量的组合物和方法 。
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Patent Agency Ranking
公开(公告)号：US20170349655A1
公开(公告)日：2017-12-07
申请号：US15626637
申请日：2017-06-19
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Mayda Perez Thiele , Xiaobei Zeng , Chee Furng Wong , Christopher M. Chumsae
CPC classification number: C07K16/241 , C07K16/00 , C07K16/2803 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/526 , C12N5/0018 , C12N2500/22 , C12N2500/32 , C12N2511/00 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.
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公开(公告)号：US09708400B2
公开(公告)日：2017-07-18
申请号：US14923958
申请日：2015-10-27
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Mayda Perez Thiele , Xiaobei Zeng , Chee Furng Wong , Christopher M. Chumsae
CPC classification number: C07K16/241 , C07K16/00 , C07K16/2803 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/526 , C12N5/0018 , C12N2500/22 , C12N2500/32 , C12N2511/00 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.
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公开(公告)号：US09315574B2
公开(公告)日：2016-04-19
申请号：US14584619
申请日：2014-12-29
Applicant: AbbVie, Inc.
Inventor： Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
IPC: C07K14/525 , A61K39/395 , C07K16/24 , C07K16/00 , A61K39/00
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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9.发明授权公开(公告)号：US09200069B2
公开(公告)日：2015-12-01
申请号：US14614311
申请日：2015-02-04
Applicant: AbbVie, Inc.
Inventor： Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
Abstract translation: 本发明涉及包含蛋白质例如抗体或其抗原结合部分的低酸性物质（AR）组合物，以及用于生产这种低AR组合物的方法，例如细胞培养和/或蛋白质纯化方法。 还提供了使用这种组合物治疗病症（例如其中TNFα有害的病症）的方法。
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公开(公告)号：US09150645B2
公开(公告)日：2015-10-06
申请号：US13830583
申请日：2013-03-14
Applicant: ABBVIE INC.
Inventor： Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Christopher Chumsae
CPC classification number: C07K16/241 , A61K39/39591 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/00 , C07K2317/14 , C07K2317/21 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
Abstract translation: 本发明涉及蛋白质生产和纯化领域，特别涉及用于控制由宿主细胞表达的酸性物质的量的组合物和方法，以及用于控制纯化制剂中存在的酸性物质的量的组合物和方法 。
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