公开(公告)号：US09840554B2

公开(公告)日：2017-12-12

申请号：US15183725

申请日：2016-06-15

Applicant: ABBVIE INC.

Inventor： Jijie Gu ,  Diana Bowley ,  Lucia Eaton ,  Feng Dong ,  Lorenzo Benatuil ,  Tariq Ghayur ,  Ravi Chari ,  Matthew Rieser ,  Anca Clabbers

IPC: C07K16/22 ,  C07K16/24 ,  A61K39/395 ,  A61K45/06 ,  C07K16/46 ,  C07K14/00 ,  A61K39/00

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/00 ,  C07K16/24 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: Binding proteins that bind one or more of VEGF, PDGF and/or their receptors, including antibodies, CDR-grafted antibodies, humanized antibodies, binding fragments, fusion proteins, and bispecific or multispecific proteins thereof are disclosed. Also disclosed are methods of making and using the binding proteins.

公开(公告)号：US09655964B2

公开(公告)日：2017-05-23

申请号：US13659666

申请日：2012-10-24

Applicant: AbbVie Inc.

Inventor： Jennifer Perez ,  Suju Zhong ,  Lucia Eaton ,  Anca Clabbers ,  Chung-Ming Hsieh ,  Lorenzo Benatuil ,  Yuliya Kutskova ,  John E. Memmott ,  Margaret Hugunin ,  Alyssa Brito

IPC: A61K39/395 ,  C07K16/24 ,  C07K16/46 ,  A61K45/06 ,  G01N33/53 ,  A61K39/00

CPC classification number: A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/244 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/5308

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.

公开(公告)号：US20140079705A1

公开(公告)日：2014-03-20

申请号：US14082502

申请日：2013-11-18

Applicant: Abbvie Inc.

Inventor： Chung-ming Hsieh ,  Jennifer Perez ,  Lorenzo Benatuil ,  Yuliya Kutskova ,  John Memmott ,  Suju Zhong ,  Lucia Eaton ,  Margaret Hugunin ,  Alyssa Brito ,  Anca Clabbers

IPC: C07K16/24 ,  C07K16/46

CPC classification number: A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/244 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/5308

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.