公开(公告)号：US20140170152A1

公开(公告)日：2014-06-19

申请号：US14073479

申请日：2013-11-06

Applicant: Abbvie Inc.

Inventor： Chung-ming Hsieh ,  Lorenzo Benatuil ,  Yuliya Kutskova ,  John Memmott ,  Jennifer Perez ,  Suju Zhong ,  Carrie Goodreau ,  Anca Clabbers

IPC: C07K16/24 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/241 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6847 ,  C07K16/464 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6863

Abstract: Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.

Abstract translation: 公开了与肿瘤坏死因子-α（TNF-α）结合的分离的结合蛋白，例如结合肿瘤坏死因子-α（TNF-α）的抗体或其抗原结合部分以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。

公开(公告)号：US09840554B2

公开(公告)日：2017-12-12

申请号：US15183725

申请日：2016-06-15

Applicant: ABBVIE INC.

Inventor： Jijie Gu ,  Diana Bowley ,  Lucia Eaton ,  Feng Dong ,  Lorenzo Benatuil ,  Tariq Ghayur ,  Ravi Chari ,  Matthew Rieser ,  Anca Clabbers

IPC: C07K16/22 ,  C07K16/24 ,  A61K39/395 ,  A61K45/06 ,  C07K16/46 ,  C07K14/00 ,  A61K39/00

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/00 ,  C07K16/24 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: Binding proteins that bind one or more of VEGF, PDGF and/or their receptors, including antibodies, CDR-grafted antibodies, humanized antibodies, binding fragments, fusion proteins, and bispecific or multispecific proteins thereof are disclosed. Also disclosed are methods of making and using the binding proteins.

公开(公告)号：US09663587B2

公开(公告)日：2017-05-30

申请号：US14262653

申请日：2014-04-25

Applicant: AbbVie Inc.

Inventor： Chung-Ming Hsieh ,  Margaret Hugunin ,  Anwar Murtaza ,  Bradford L. McRae ,  Yuliya Kutskova ,  John E. Memmott ,  Jennifer M. Perez ,  Suju Zhong ,  Edit Tarcsa ,  Anca Clabbers ,  Craig Wallace ,  Shaughn H. Bryant ,  Mary R. Leddy

IPC: C07K16/46 ,  C07K16/24 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/466

Abstract: Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

公开(公告)号：US09481736B2

公开(公告)日：2016-11-01

申请号：US14263724

申请日：2014-04-28

Applicant: AbbVie Inc.

Inventor： Chung-Ming Hsieh ,  Margaret Hugunin ,  Anwar Murtaza ,  Bradford L. McRae ,  Yuliya Kutskova ,  John E. Memmott ,  Jennifer M. Perez ,  Suju Zhong ,  Edit Tarcsa ,  Anca Clabbers ,  Craig Wallace ,  Shaughn H. Bryant ,  Mary R. Leddy

IPC: C07K16/46 ,  C07K16/24 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/466

Abstract: Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-17和/或IL-17F的蛋白质及其在用于治疗，预防和诊断IL-17相关疾病和用于检测细胞，组织，样品和组合物中的IL-17的组合物和方法中的用途。

公开(公告)号：US20140079705A1

公开(公告)日：2014-03-20

申请号：US14082502

申请日：2013-11-18

Applicant: Abbvie Inc.

Inventor： Chung-ming Hsieh ,  Jennifer Perez ,  Lorenzo Benatuil ,  Yuliya Kutskova ,  John Memmott ,  Suju Zhong ,  Lucia Eaton ,  Margaret Hugunin ,  Alyssa Brito ,  Anca Clabbers

IPC: C07K16/24 ,  C07K16/46

CPC classification number: A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/244 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/5308

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.

公开(公告)号：US09803009B2

公开(公告)日：2017-10-31

申请号：US13659658

申请日：2012-10-24

Applicant: AbbVie Inc.

Inventor： Chung-Ming Hsieh ,  Lorenzo Benatuil ,  Yuliya Kutskova ,  John Memmott ,  Jennifer Perez ,  Suju Zhong ,  Carrie Goodreau ,  Anca Clabbers

IPC: A61K39/395 ,  A61K39/00 ,  C12P21/08 ,  C07K16/00 ,  C07K16/24 ,  C07K16/46 ,  G01N33/68 ,  A61K47/48 ,  A61K45/06

CPC classification number: C07K16/241 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6847 ,  C07K16/464 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6863

Abstract: Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US09655964B2

公开(公告)日：2017-05-23

申请号：US13659666

申请日：2012-10-24

Applicant: AbbVie Inc.

Inventor： Jennifer Perez ,  Suju Zhong ,  Lucia Eaton ,  Anca Clabbers ,  Chung-Ming Hsieh ,  Lorenzo Benatuil ,  Yuliya Kutskova ,  John E. Memmott ,  Margaret Hugunin ,  Alyssa Brito

IPC: A61K39/395 ,  C07K16/24 ,  C07K16/46 ,  A61K45/06 ,  G01N33/53 ,  A61K39/00

CPC classification number: A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/244 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/5308

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.

公开(公告)号：US09481735B2

公开(公告)日：2016-11-01

申请号：US14261257

申请日：2014-04-24

Applicant: AbbVie Inc.

Inventor： Chung-Ming Hsieh ,  Margaret Hugunin ,  Anwar Murtaza ,  Bradford L. McRae ,  Yuliya Kutskova ,  John E. Memmott ,  Jennifer M. Perez ,  Suju Zhong ,  Edit Tarcsa ,  Anca Clabbers ,  Craig Wallace ,  Shaughn H. Bryant ,  Mary R. Leddy

IPC: C07K16/24 ,  C07K16/46 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/466

Abstract: Proteins that bind IL-17 and/or IL-17F are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-17和/或IL-17F的蛋白质及其在用于治疗，预防和诊断IL-17相关疾病和用于检测细胞，组织，样品和组合物中的IL-17的组合物和方法中的用途。