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公开(公告)号：US09670276B2
公开(公告)日：2017-06-06
申请号：US13940506
申请日：2013-07-12
Applicant: AbbVie Inc.
Inventor： Susan E. Lacy , Lorenzo Benatuil , Meha Chhaya , Emma Fung , Renee Miller , Ravi Chari , Sarah J. Heighton , Jacqueline G. Bixby
IPC: C12P21/08 , A61K39/395 , C07K16/24 , A61K39/00
CPC classification number: C07K16/245 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/60 , C07K2317/622 , C07K2317/76 , C07K2317/92
Abstract: The disclosure provides binding proteins that specifically bind to IL-1α and IL-1β. These binding proteins can be organized into DVD-Igs. These proteins can be used to modulate the activity of IL-1α and/or IL-1β and can be used for the treatment immunological diseases such as rheumatoid arthritis, osteoarthritis, psoriasis, multiple sclerosis, and other autoimmune diseases. In addition, their uses in the amelioration and/or treatment of pain in an individual suffering from a disease or disorder associated with IL-1 accumulation.
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2.发明申请ANTI-DLL4/VEGF DUAL VARIABLE DOMAIN IMMUNOGLOBULIN AND USES THEREOF 审中-公开ANTI-DLL4 / VEGF双变异型域免疫球蛋白及其用途公开(公告)号：US20160122439A1
公开(公告)日：2016-05-05
申请号：US14845511
申请日：2015-09-04
Applicant: AbbVie Inc.
Inventor： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
CPC classification number: C07K16/468 , A61K31/337 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/525 , A61K31/7068 , A61K39/395 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
Abstract: Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases diseases characterized by aberrant DLL4 and/or VEGF expression or activity.
Abstract translation: 本文公开了多价和多特异性结合蛋白，制备结合蛋白的方法及其在诊断，监测，抑制，预防和/或治疗癌症，肿瘤和/或其它血管发生依赖性疾病中的用途，所述疾病以异常DLL4为特征 和/或VEGF表达或活性。
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3.发明授权公开(公告)号：US09045551B2
公开(公告)日：2015-06-02
申请号：US14301546
申请日：2014-06-11
Applicant: AbbVie Inc.
Inventor： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
IPC: C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07K16/46 , A61K45/06 , C07K16/22 , A61K31/513 , A61K31/7068 , A61K31/337 , A61K31/4745 , A61K31/495 , A61K31/525 , C07K16/28 , C07K1/00 , A61K39/00
CPC classification number: C07K16/468 , A61K31/337 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/525 , A61K31/7068 , A61K39/395 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
Abstract: Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases characterized by aberrant DLL4 and/or VEGF expression or activity.
Abstract translation: 本文公开了多价和多特异性结合蛋白，制备结合蛋白的方法及其在诊断，监测，抑制，预防和/或治疗癌症，肿瘤和/或其它血管发生依赖性疾病中的用途，其特征在于异常DLL4和 /或VEGF表达或活性。
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Patent Agency Ranking
公开(公告)号：US20190031783A1
公开(公告)日：2019-01-31
申请号：US15914856
申请日：2018-03-07
Applicant: AbbVie Inc.
Inventor： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
IPC: C07K16/46 , C07K16/22 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/525 , A61K31/7068 , A61K39/395 , A61K45/06 , A61K31/337 , C07K16/28 , A61K39/00
Abstract: Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases diseases characterized by aberrant DLL4 and/or VEGF expression or activity.
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公开(公告)号：US09944720B2
公开(公告)日：2018-04-17
申请号：US14845511
申请日：2015-09-04
Applicant: AbbVie Inc.
Inventor： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
IPC: C07H21/04 , C12P21/06 , C12N1/12 , C12N1/20 , C12N15/00 , C12N5/00 , C07K16/46 , A61K45/06 , C07K16/22 , A61K39/395 , A61K31/513 , A61K31/7068 , A61K31/337 , A61K31/4745 , A61K31/495 , A61K31/525 , C07K16/28 , C07K16/00 , A61K39/00
CPC classification number: C07K16/468 , A61K31/337 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/525 , A61K31/7068 , A61K39/395 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
Abstract: Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases diseases characterized by aberrant DLL4 and/or VEGF expression or activity.
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公开(公告)号：US09840554B2
公开(公告)日：2017-12-12
申请号：US15183725
申请日：2016-06-15
Applicant: ABBVIE INC.
Inventor： Jijie Gu , Diana Bowley , Lucia Eaton , Feng Dong , Lorenzo Benatuil , Tariq Ghayur , Ravi Chari , Matthew Rieser , Anca Clabbers
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/00 , C07K16/24 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/51 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Binding proteins that bind one or more of VEGF, PDGF and/or their receptors, including antibodies, CDR-grafted antibodies, humanized antibodies, binding fragments, fusion proteins, and bispecific or multispecific proteins thereof are disclosed. Also disclosed are methods of making and using the binding proteins.
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公开(公告)号：US20220403052A1
公开(公告)日：2022-12-22
申请号：US17588094
申请日：2022-01-28
Applicant: AbbVie Inc.
Inventor： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
IPC: C07K16/46 , A61K45/06 , C07K16/22 , A61K39/395 , A61K31/513 , A61K31/7068 , A61K31/337 , A61K31/4745 , A61K31/495 , A61K31/525 , C07K16/28
Abstract: Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases diseases characterized by aberrant DLL4 and/or VEGF expression or activity.
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8.发明申请ANTI-DLL4/VEGF DUAL VARIABLE DOMAIN IMMUNOGLOBULIN AND USES THEREOF 有权ANTI-DLL4 / VEGF双变异型域免疫球蛋白及其用途公开(公告)号：US20140348835A1
公开(公告)日：2014-11-27
申请号：US14301546
申请日：2014-06-11
Applicant: AbbVie Inc.
Inventor： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
IPC: C07K16/46 , A61K31/4745 , A61K31/525 , C07K16/28 , A61K31/7068 , A61K31/337 , A61K31/513 , C07K16/22 , A61K39/395 , A61K31/495
CPC classification number: C07K16/468 , A61K31/337 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/525 , A61K31/7068 , A61K39/395 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
Abstract: Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases diseases characterized by aberrant DLL4 and/or VEGF expression or activity.
Abstract translation: 本文公开了多价和多特异性结合蛋白，制备结合蛋白的方法及其在诊断，监测，抑制，预防和/或治疗癌症，肿瘤和/或其它血管发生依赖性疾病中的用途，所述疾病以异常DLL4为特征 和/或VEGF表达或活性。
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