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公开(公告)号：US20220306740A1
公开(公告)日：2022-09-29
申请号：US17516350
申请日：2021-11-01
Applicant: AbbVie Inc.
Inventor： Adam S. Chervin , Feng Dong , Edward B. Reilly , Jennifer D. Stone , Michael K. White
IPC: C07K16/28 , C07K14/725 , C07K16/18
Abstract: The present disclosure provides novel bispecific molecules that binds to human Survivin and human CD3, and methods of making and using the same.
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公开(公告)号：US20180194861A1
公开(公告)日：2018-07-12
申请号：US15742331
申请日：2016-07-08
Applicant: AbbVie Inc.
Inventor： Feng Dong , Jijie Gu , Tariq Ghayur
IPC: C07K16/46
CPC classification number: C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/64 , C07K2319/00 , C07K2319/30
Abstract: Engineered binding proteins comprising a modified constant region, such as an IgG constant region modified to contain a CH2 domain from an IgM, a CH2 domain from an IgE, or a variant thereof, are disclosed. The binding proteins can be multispecific, including bi-, tri-, and tetra-specific constructs. Also disclosed are uses of the binding proteins in the diagnosis, prevention, and/or treatment of disease.
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Patent Agency Ranking
公开(公告)号：US20210253700A1
公开(公告)日：2021-08-19
申请号：US17175501
申请日：2021-02-12
Applicant: AbbVie Inc.
Inventor： Adam S. Chervin , Feng Dong , Edward B. Reilly , Jennifer D. Stone , MIchael K. White
IPC: C07K16/28 , C07K14/725 , C07K16/18
Abstract: The present disclosure provides novel bispecific molecules that binds to human Survivin and human CD3, and methods of making and using the same.
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公开(公告)号：US09840554B2
公开(公告)日：2017-12-12
申请号：US15183725
申请日：2016-06-15
Applicant: ABBVIE INC.
Inventor： Jijie Gu , Diana Bowley , Lucia Eaton , Feng Dong , Lorenzo Benatuil , Tariq Ghayur , Ravi Chari , Matthew Rieser , Anca Clabbers
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/00 , C07K16/24 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/51 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Binding proteins that bind one or more of VEGF, PDGF and/or their receptors, including antibodies, CDR-grafted antibodies, humanized antibodies, binding fragments, fusion proteins, and bispecific or multispecific proteins thereof are disclosed. Also disclosed are methods of making and using the binding proteins.
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公开(公告)号：US11639390B2
公开(公告)日：2023-05-02
申请号：US17378565
申请日：2021-07-16
Applicant: AbbVie Inc.
Inventor： Jing Min , Teresa (Iok-Chan) Ng , Lorenzo Benatuil , Jacqueline Bixby , Tatyana Dekhtyar , Feng Dong , Axel Hernandez, Jr. , Preethi Krishnan , Liangjun Lu , Federico Mensa , Renee Miller , Gautam Sahu
IPC: C12N5/02 , C12N5/20 , C12N1/20 , C12N15/00 , C07K16/46 , C07K16/00 , C07H21/04 , C07K16/28 , A61P31/18 , C12N15/63 , A61K39/00
Abstract: The present disclosure provides anti-α4β7 antibodies that bind human α4β7, their methods of making, and their uses to treat patients with HIV infection.
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公开(公告)号：US20220017624A1
公开(公告)日：2022-01-20
申请号：US17378565
申请日：2021-07-16
Applicant: AbbVie Inc.
Inventor： Jing Min , Teresa (Iok-Chan) Ng , Lorenzo Benatuil , Jacqueline Bixby , Tatyana Dekhtyar , Feng Dong , Axel Hernandez, Jr. , Preethi Krishnan , Liangjun Lu , Federico Mensa , Renee Miller , Gautam Sahu
Abstract: The present disclosure provides anti-α4β7 antibodies that bind human α4β7, their methods of making, and their uses to treat patients with HIV infection.
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公开(公告)号：US09550986B2
公开(公告)日：2017-01-24
申请号：US14136076
申请日：2013-12-20
Applicant: AbbVie, Inc.
Inventor： Feng Dong , Lorenzo Benatuil , Jijie Gu , Chung-Ming Hsieh
CPC classification number: C12N15/1089 , C07K16/465 , C40B30/02
Abstract: The present invention relates to improved methods for antibody engineering, e.g., humanization. In particular, the disclosure provides a high-throughput antibody humanization process that can be automated by computer-implementation.
Abstract translation: 本发明涉及用于抗体工程的改进方法，例如人源化。 具体地，本公开提供了可以通过计算机实现来自动化的高通量抗体人源化过程。
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