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公开(公告)号：US12005102B2
公开(公告)日：2024-06-11
申请号：US17091553
申请日：2020-11-06
Applicant: AC Immune SA
Inventor： Emma Fiorini , Marija Vukicevic Verhille , Maria Pihlgren Bosch
IPC: A61K39/395 , A61K9/127 , A61K39/00 , A61K39/05 , A61K39/08 , A61K39/245 , A61K39/39 , A61P25/28 , C07K14/005
CPC classification number: A61K39/0007 , A61K9/127 , A61K39/0003 , A61K39/0005 , A61K39/05 , A61K39/08 , A61K39/245 , A61K39/39 , A61P25/28 , C07K14/005 , A61K2039/55516 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/575 , A61K2039/58 , A61K2039/627 , A61K2039/645 , A61K2039/70 , C07K2319/33 , C07K2319/55 , C12N2710/16232 , C12N2710/16234 , C12N2760/16033
Abstract: A liposomal vaccine composition comprises a β-amyloid (Aβ)-derived peptide antigen displayed on the surface of the liposome. The vaccine composition also comprises a peptide comprising a universal T-cell epitope encapsulated within the liposome. The vaccine composition also comprises an adjuvant, which may form part of the liposome and may be displayed at least in part on the surface of the liposome. These vaccine compositions are used for treating, preventing, inducing a protective immune response against or alleviating the symptoms associated with an amyloid-beta associated disease or condition or a condition characterised by, or associated with, loss of cognitive memory capacity in a subject. The vaccine compositions may be provided as a kit. Related methods of producing a liposomal vaccine composition are also provided.
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公开(公告)号：US20230381108A1
公开(公告)日：2023-11-30
申请号：US18316829
申请日：2023-05-12
Applicant: AC Immune SA , Janssen Pharmaceuticals, Inc.
Inventor： Andrea Pfeifer , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , Nicolas Piot , Saroj Raj Ghimire , Elizabeth Anne Ramsburg , Donata De Marco , Charlotte Sadaka
CPC classification number: A61K9/1271 , A61P25/28 , A61K39/0007 , A61K2039/545 , A61K2039/627 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , A61K2039/55516
Abstract: Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist and a Tau phosphopeptide presented on the surface of the liposome.
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公开(公告)号：US20210093700A1
公开(公告)日：2021-04-01
申请号：US17091553
申请日：2020-11-06
Applicant: AC Immune SA
Inventor： Emma Fiorini , Marija Vukicevic Verhille , Maria Pihlgren Bosch
IPC: A61K39/00 , A61K9/127 , A61K39/05 , A61K39/08 , A61K39/245 , A61P25/28 , A61K39/39 , C07K14/005
Abstract: A liposomal vaccine composition comprises a β-amyloid (Aβ)-derived peptide antigen displayed on the surface of the liposome. The vaccine composition also comprises a peptide comprising a universal T-cell epitope encapsulated within the liposome. The vaccine composition also comprises an adjuvant, which may form part of the liposome and may be displayed at least in part on the surface of the liposome. These vaccine compositions are used for treating, preventing, inducing a protective immune response against or alleviating the symptoms associated with an amyloid-beta associated disease or condition or a condition characterised by, or associated with, loss of cognitive memory capacity in a subject. The vaccine compositions may be provided as a kit. Related methods of producing a liposomal vaccine composition are also provided.
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公开(公告)号：US20240350598A1
公开(公告)日：2024-10-24
申请号：US18650535
申请日：2024-04-30
Applicant: AC Immune SA
Inventor： Emma Fiorini , Marija Vukicevic Verhille , Maria Pihlgren Bosch
IPC: A61K39/00 , A61K9/127 , A61K39/05 , A61K39/08 , A61K39/245 , A61K39/39 , A61P25/28 , C07K14/005
CPC classification number: A61K39/0007 , A61K9/127 , A61K39/0003 , A61K39/0005 , A61K39/05 , A61K39/08 , A61K39/245 , A61K39/39 , A61P25/28 , C07K14/005 , A61K2039/55516 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/575 , A61K2039/58 , A61K2039/627 , A61K2039/645 , A61K2039/70 , C07K2319/33 , C07K2319/55 , C12N2710/16232 , C12N2710/16234 , C12N2760/16033
Abstract: A liposomal vaccine composition comprises a β-amyloid (Aβ)-derived peptide antigen displayed on the surface of the liposome. The vaccine composition also comprises a peptide comprising a universal T-cell epitope encapsulated within the liposome. The vaccine composition also comprises an adjuvant, which may form part of the liposome and may be displayed at least in part on the surface of the liposome. These vaccine compositions are used for treating, preventing, inducing a protective immune response against or alleviating the symptoms associated with an amyloid-beta associated disease or condition or a condition characterised by, or associated with, loss of cognitive memory capacity in a subject. The vaccine compositions may be provided as a kit. Related methods of producing a liposomal vaccine composition are also provided.
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公开(公告)号：US20190307867A1
公开(公告)日：2019-10-10
申请号：US16379322
申请日：2019-04-09
Applicant: AC Immune SA
Inventor： Emma Fiorini , Marija Vukicevic Verhille , Maria Pihlgren Bosch
Abstract: A liposomal vaccine composition comprises a β-amyloid (Aβ)-derived peptide antigen displayed on the surface of the liposome. The vaccine composition also comprises a peptide comprising a universal T-cell epitope encapsulated within the liposome. The vaccine composition also comprises an adjuvant, which may form part of the liposome and may be displayed at least in part on the surface of the liposome. These vaccine compositions are used for treating, preventing, inducing a protective immune response against or alleviating the symptoms associated with an amyloid-beta associated disease or condition or a condition characterised by, or associated with, loss of cognitive memory capacity in a subject. The vaccine compositions may be provided as a kit. Related methods of producing a liposomal vaccine composition are also provided.
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Patent Agency Ranking
公开(公告)号：US11958889B2
公开(公告)日：2024-04-16
申请号：US16757621
申请日：2018-10-24
Applicant: Janssen Pharmaceuticals, Inc. , AC Immune SA
Inventor： Elizabeth Anne Ramsburg , Donata de Marco , Charlotte Sadaka , Jaap Goudsmit , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , David Hickman , Nicolas Piot , Saroj Raj Ghimire
CPC classification number: C07K14/4711 , A61K9/127 , A61K9/1271 , A61K38/1709 , A61K39/0007 , A61K39/39 , A61P25/28 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , A61K2039/627
Abstract: Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.
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公开(公告)号：US11684576B2
公开(公告)日：2023-06-27
申请号：US16785011
申请日：2020-02-07
Applicant: AC Immune SA , Janssen Pharmaceuticals, Inc.
Inventor： Andrea Pfeifer , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , Nicolas Piot , Saroj Raj Ghimire , Elizabeth Anne Ramsburg , Donata De Marco , Charlotte Sadaka
CPC classification number: A61K9/1271 , A61K39/0007 , A61P25/28 , A61K2039/545 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , A61K2039/627
Abstract: Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist and a Tau phosphopeptide presented on the surface of the liposome.
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公开(公告)号：US20230257433A1
公开(公告)日：2023-08-17
申请号：US18171498
申请日：2023-02-20
Applicant: Janssen Pharmaceuticals, Inc. , AC Immune SA
Inventor： Elizabeth Anne Ramsburg , Donata De Marco , Chakkumkal Anish , Charlotte Sadaka , Jaap Goudsmit , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , David Hickman , Nicolas Piot , Saroj Raj Ghimire
CPC classification number: C07K14/4711 , A61K39/0007 , A61K9/1271 , A61K2039/627 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , A61K2039/55516
Abstract: Methods for inducing an immune response against tau protein in a subject suffering from a neurodegenerative disease, disorder or condition, such as Alzheimer's Disease, are described. The methods include administering a liposomal priming composition containing tau peptides, preferably phosphorylated tau peptides, and a conjugate boosting composition containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier.
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公开(公告)号：US11591377B2
公开(公告)日：2023-02-28
申请号：US16856400
申请日：2020-04-23
Applicant: Janssen Pharmaceuticals, Inc. , AC Immune SA
Inventor： Elizabeth Anne Ramsburg , Donata De Marco , Chakkumkal Anish , Charlotte Sadaka , Jaap Goudsmit , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , David Hickman , Nicolas Piot , Saroj Raj Ghimire
Abstract: Methods for inducing an immune response against tau protein in a subject suffering from a neurodegenerative disease, disorder or condition, such as Alzheimer's Disease, are described. The methods include administering a liposomal priming composition containing tau peptides, preferably phosphorylated tau peptides, and a conjugate boosting composition containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier.
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公开(公告)号：US11124552B2
公开(公告)日：2021-09-21
申请号：US16169215
申请日：2018-10-24
Applicant: Janssen Pharmaceuticals, Inc. , AC Immune SA
Inventor： Elizabeth Anne Ramsburg , Donata De Marco , Charlotte Sadaka , Jaap Goudsmit , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , Nicolas Piot , Saroj Raj Ghimire
Abstract: Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.
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