-
公开(公告)号：US20140377216A1
公开(公告)日：2014-12-25
申请号：US14367681
申请日：2012-12-22
申请人： ADAMED SP. Z.O.O.
发明人： Jerzy Szczepan Pieczykolan , Sebastian Dominik Pawlak , Bartlomiej Maciej Zerek , Piotr Kamil Rozga
IPC分类号： C07K14/525 , C07K7/08 , C07K14/435 , C12N9/16 , C07K14/005 , C12N7/00 , C07K14/195 , C07K14/32 , C07K14/47 , C07K14/46
CPC分类号： C07K14/525 , C07K7/08 , C07K7/086 , C07K14/005 , C07K14/195 , C07K14/32 , C07K14/43563 , C07K14/43572 , C07K14/461 , C07K14/463 , C07K14/47 , C07K14/70575 , C07K2319/00 , C12N7/00 , C12N9/16 , C12N2760/16033 , C12Y301/04003
摘要： A fusion protein comprising domain (a) which is a functional fragment of hTRAIL protein sequence, which fragment begins with an amino acid at a position not lower than hTRAIL95, or a homolog of said functional fragment having at least 70% sequence identity, preferably 85% identity and ending with the amino acid hTRAIL281; and at least one domain (b) which is a sequence of a cytolytic effector peptide forming pores in the cell membrane, wherein the sequence of domain (b) is attached at the C-terminus or N-terminus of domain (a). The fusion protein can be used for the treatment of cancer diseases.
摘要翻译： 一种融合蛋白，其包含作为hTRAIL蛋白序列的功能片段的结构域（a），所述片段以不低于hTRAIL95的氨基酸开始，或所述功能片段的同源物具有至少70％的序列同一性，优选为85 ％同一性，以氨基酸hTRAIL281结尾; 和至少一个结构域（b），其是在细胞膜中形成孔的细胞溶解效应肽的序列，其中结构域（b）的序列连接在结构域（a）的C末端或N末端。 融合蛋白可用于治疗癌症。
-
2.发明申请公开(公告)号：US20150071952A1
公开(公告)日：2015-03-12
申请号：US14378568
申请日：2013-02-14
发明人： Ashish Fnu , Kalpana Pandey , Yogendra Rathore
IPC分类号： C07K7/06 , C12N7/00 , C07K14/005 , C07K7/08 , C07K5/113
CPC分类号： C07K7/06 , A61K39/145 , C07K5/1021 , C07K7/08 , C07K14/005 , C12N7/00 , C12N2760/16022 , C12N2760/16033 , C12N2760/16034
摘要： The invention provides peptides capable of binding with influenza hemagglutinin (HA) protein blocking pH-induced shape change or aggregation of the influenza hemagglutinin (HA) protein. The invention also provides a druggable site in influenza Hemagglutinin protein, said druggable site comprises peptide sequences comprising conserved residues.
摘要翻译： 本发明提供能够与流感血凝素（HA）蛋白结合的肽，其阻止pH诱导的流感血凝素（HA）蛋白的形状变化或聚集。 本发明还提供了流感血凝素蛋白中的可药物部位，所述药物部位包含含有保守残基的肽序列。
-
公开(公告)号：US12005102B2
公开(公告)日：2024-06-11
申请号：US17091553
申请日：2020-11-06
申请人： AC Immune SA
IPC分类号： A61K39/395 , A61K9/127 , A61K39/00 , A61K39/05 , A61K39/08 , A61K39/245 , A61K39/39 , A61P25/28 , C07K14/005
CPC分类号： A61K39/0007 , A61K9/127 , A61K39/0003 , A61K39/0005 , A61K39/05 , A61K39/08 , A61K39/245 , A61K39/39 , A61P25/28 , C07K14/005 , A61K2039/55516 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/575 , A61K2039/58 , A61K2039/627 , A61K2039/645 , A61K2039/70 , C07K2319/33 , C07K2319/55 , C12N2710/16232 , C12N2710/16234 , C12N2760/16033
摘要： A liposomal vaccine composition comprises a β-amyloid (Aβ)-derived peptide antigen displayed on the surface of the liposome. The vaccine composition also comprises a peptide comprising a universal T-cell epitope encapsulated within the liposome. The vaccine composition also comprises an adjuvant, which may form part of the liposome and may be displayed at least in part on the surface of the liposome. These vaccine compositions are used for treating, preventing, inducing a protective immune response against or alleviating the symptoms associated with an amyloid-beta associated disease or condition or a condition characterised by, or associated with, loss of cognitive memory capacity in a subject. The vaccine compositions may be provided as a kit. Related methods of producing a liposomal vaccine composition are also provided.
-
公开(公告)号：US20150056653A1
公开(公告)日：2015-02-26
申请号：US14235908
申请日：2012-07-27
申请人： George E. Pierce , Susan A. Burran , Trudy Ann Tucker , Shelby Jones-Dozier , Jennifer Hooker , Sidney A. Crow, JR.
发明人： George E. Pierce , Susan A. Burran , Trudy Ann Tucker , Shelby Jones-Dozier , Jennifer Hooker , Sidney A. Crow, JR.
IPC分类号： C07K14/005 , C12N7/00 , C07K14/255
CPC分类号： C12P21/02 , A61K39/00 , B01D15/327 , B01D15/363 , C07K1/18 , C07K14/005 , C07K14/195 , C07K14/255 , C07K2319/30 , C07K2319/40 , C07K2319/42 , C12N7/00 , C12N2760/16031 , C12N2760/16033 , C12N2760/16034 , C12N2760/16041 , C12N2760/16051
摘要： Provided herein are methods of producing a heterologous polypeptide and compositions comprising same.
摘要翻译： 本文提供了产生异源多肽的方法及其组合物。
-
公开(公告)号：US20240350598A1
公开(公告)日：2024-10-24
申请号：US18650535
申请日：2024-04-30
申请人： AC Immune SA
IPC分类号： A61K39/00 , A61K9/127 , A61K39/05 , A61K39/08 , A61K39/245 , A61K39/39 , A61P25/28 , C07K14/005
CPC分类号： A61K39/0007 , A61K9/127 , A61K39/0003 , A61K39/0005 , A61K39/05 , A61K39/08 , A61K39/245 , A61K39/39 , A61P25/28 , C07K14/005 , A61K2039/55516 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/575 , A61K2039/58 , A61K2039/627 , A61K2039/645 , A61K2039/70 , C07K2319/33 , C07K2319/55 , C12N2710/16232 , C12N2710/16234 , C12N2760/16033
摘要： A liposomal vaccine composition comprises a β-amyloid (Aβ)-derived peptide antigen displayed on the surface of the liposome. The vaccine composition also comprises a peptide comprising a universal T-cell epitope encapsulated within the liposome. The vaccine composition also comprises an adjuvant, which may form part of the liposome and may be displayed at least in part on the surface of the liposome. These vaccine compositions are used for treating, preventing, inducing a protective immune response against or alleviating the symptoms associated with an amyloid-beta associated disease or condition or a condition characterised by, or associated with, loss of cognitive memory capacity in a subject. The vaccine compositions may be provided as a kit. Related methods of producing a liposomal vaccine composition are also provided.
-
公开(公告)号：US12104196B2
公开(公告)日：2024-10-01
申请号：US17255526
申请日：2019-06-27
申请人： MEDICAGO INC.
IPC分类号： C07K14/005 , A61K39/145 , A61P31/16 , A61P37/04 , C07K14/11 , C07K16/10 , C12N7/00 , C12N15/82 , C12P21/02 , A61K38/00 , A61K39/00
CPC分类号： C12P21/02 , A61K39/145 , A61P31/16 , A61P37/04 , C07K14/005 , C07K14/11 , C07K16/10 , C07K16/1018 , C12N7/00 , C12N15/8257 , C12N15/8258 , A61K38/00 , A61K2039/5258 , C12N2760/16023 , C12N2760/16033 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16152
摘要： The present invention relates to the production of modified influenza viral proteins in plants. More specifically, the present invention relates to producing and increasing influenza virus-like particle (VLP) production in plants, wherein the VLPs comprise the modified influenza viral proteins, such as modified influenza hemagglutinin (HA). The HA protein may comprising an amino acid sequence comprising at least one substitution when compared to a corresponding wildtype amino acid sequence. Further provided are nucleic acid encoding the modified HA protein. Furthermore methods of producing an influenza virus like particle (VLP) and methods of increasing yield of production of an influenza virus like particle (VLP) in a plant, portion of a plant, or a plant cell, are also provided.
-
公开(公告)号：US20170114383A1
公开(公告)日：2017-04-27
申请号：US15400291
申请日：2017-01-06
发明人： George E. Pierce , Susan A. Burran , Trudy Ann Tucker , Shelby Jones-Dozier , Jennifer Hooker , Sidney A. Crow, JR.
IPC分类号： C12P21/02 , B01D15/32 , C07K14/005 , B01D15/36 , C07K1/18 , C07K14/255
CPC分类号： C12P21/02 , A61K39/00 , B01D15/327 , B01D15/363 , C07K1/18 , C07K14/005 , C07K14/195 , C07K14/255 , C07K2319/30 , C07K2319/40 , C07K2319/42 , C12N7/00 , C12N2760/16031 , C12N2760/16033 , C12N2760/16034 , C12N2760/16041 , C12N2760/16051
摘要： Provided herein are methods of producing a heterologous polypeptide and compositions comprising same.
-
公开(公告)号：US09458196B2
公开(公告)日：2016-10-04
申请号：US14378568
申请日：2013-02-14
IPC分类号： C07K7/60 , C07K14/11 , A61K39/145 , C07K7/06 , C07K14/005 , C07K5/113 , C07K7/08 , C12N7/00
CPC分类号： C07K7/06 , A61K39/145 , C07K5/1021 , C07K7/08 , C07K14/005 , C12N7/00 , C12N2760/16022 , C12N2760/16033 , C12N2760/16034
摘要： The invention provides peptides capable of binding with influenza hemagglutinin (HA) protein blocking pH-induced shape change or aggregation of the influenza hemagglutinin (HA) protein. The invention also provides a druggable site in influenza Hemagglutinin protein, said druggable site comprises peptide sequences comprising conserved residues.
摘要翻译： 本发明提供能够与流感血凝素（HA）蛋白结合的肽，其阻止pH诱导的流感血凝素（HA）蛋白的形状变化或聚集。 本发明还提供了流感血凝素蛋白中的可药物部位，所述药物部位包含含有保守残基的肽序列。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.012 秒)
