公开(公告)号：US09763431B2

公开(公告)日：2017-09-19

申请号：US14920497

申请日：2015-10-22

Applicant: ACADEMIA SINICA ,  Yu-Ho Lin

Inventor： Yu-Ho Lin ,  Jyh-Yih Chen

IPC: A01K67/027 ,  C12N15/85 ,  C07K14/46

CPC classification number: A01K67/0275 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2227/40 ,  A01K2267/02 ,  A01K2267/0393 ,  C07K14/461 ,  C12N15/8509 ,  C12N2830/008

Abstract: The preset invention relates to a promoter to target a fluorescent protein to the muscles of fish, such as A. nigrofasciatus, for ornamental purposes, which is a Mlc3 (myosin, light polypeptide 3, skeletal muscle) promoter. The Mlc3 promoter has the nucleotides of tilapia (Oreochromis niloticus) myosin light chain 3 (Mlc3) promoter region, which is potential to be a tilapia Mlc3 promoter to enhance protein expression in muscle of fish, particularly for the generation of ornamental fish.

公开(公告)号：US20160346348A1

公开(公告)日：2016-12-01

申请号：US14723914

申请日：2015-05-28

Applicant: Academia Sinica ,  National Sun Yat-sen University

Inventor： Zhi-Hong Wen ,  Jyh-Yih Chen

IPC: A61K38/17

CPC classification number: A61K38/1706

Abstract: The present invention relates to a method for alleviating pain in a subject in need thereof, which comprises administering an effective amount of piscidin (PCD) peptide and a pharmaceutically acceptable carrier to the subject.

Abstract translation: 本发明涉及一种减轻有需要的受试者疼痛的方法，其包括将有效量的皮屑（PCD）肽和药学上可接受的载体给予受试者。

公开(公告)号：US09901615B2

公开(公告)日：2018-02-27

申请号：US15098486

申请日：2016-04-14

Applicant: Academia Sinica ,  National Taiwan Ocean University

Inventor： Jyh-Yih Chen ,  Chang-Jer Wu

IPC: A61K38/17 ,  C07K14/435 ,  A61P31/04

CPC classification number: A61K38/1706

Abstract: The preset invention relates to a new method or composition for treating a gastric ulcer, preventing or treating an infection of H. pylori, particularly multidrug resistant H. pylori, using an antimicrobial peptide, a functional derivate, fragment or variant thereof, wherein the antimicrobial peptide is selected from the group consisting of Epi-1, TPs and combination thereof.

公开(公告)号：US09623077B2

公开(公告)日：2017-04-18

申请号：US14723914

申请日：2015-05-28

Applicant: Academia Sinica ,  National Sun Yat-sen University

Inventor： Zhi-Hong Wen ,  Jyh-Yih Chen

IPC: A61K38/00 ,  A61K38/16 ,  C07K14/00 ,  A61K38/17

CPC classification number: A61K38/1706

Abstract: The present invention relates to a method for alleviating pain in a subject in need thereof, which comprises administering an effective amount of piscidin (PCD) peptide and a pharmaceutically acceptable carrier to the subject.

公开(公告)号：US10232013B2

公开(公告)日：2019-03-19

申请号：US15403595

申请日：2017-01-11

Applicant: Academia Sinica

Inventor： Jyh-Yih Chen ,  Chen-Hung Ting

IPC: A61K45/06 ,  A61K45/00 ,  A61K38/17 ,  A61K38/00

Abstract: The preset invention relates to a new approach for treating a cancer, particularly a malignant tumor, a multidrug-resistant (MDR) cancer, a recurrent cancer or a metastatic cancer, using a specific cationic antimicrobial peptide (CAP), tilapia piscidin 4 (TP4), which is derived from Nile Tilapia (Oreochromis niloticus). Also provided is a method for treating a breast cancer, particularly triple negative breast cancer (TNBC) with TP4.

公开(公告)号：US09925235B2

公开(公告)日：2018-03-27

申请号：US15137281

申请日：2016-04-25

Applicant: Academia Sinica ,  National Taiwan Ocean University

Inventor： Jyh-Yih Chen ,  Chang-Jer Wu

IPC: A61K38/16 ,  A61K38/17 ,  C07K14/00 ,  C07K4/12

CPC classification number: A61K38/1706

Abstract: A method for enhancing wound healing or treating methicillin-resistant Staphylococcus aureus (MRSA) infection in a wound comprising administering a subject in need thereof with a therapeutically effective amount of a tilapia piscidin (TP) is described, wherein the TP is preferably TP3 or TP4.

公开(公告)号：US09750844B2

公开(公告)日：2017-09-05

申请号：US14857189

申请日：2015-09-17

Applicant: ACADEMIA SINICA ,  NATIONAL TAIWAN OCEAN UNIVERSITY

Inventor： Jyh-Yih Chen ,  Chang-Jer Wu ,  Han-Ning Huang

IPC: A61L26/00 ,  A61L15/46 ,  A61L15/32

CPC classification number: A61L26/0047 ,  A61L15/32 ,  A61L15/325 ,  A61L15/46 ,  A61L26/0033 ,  A61L26/0066 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/412

Abstract: The preset invention relates to a new method for wound healing, particularly in burns, comprising Epinecidin-1 (Epi-1) or Pardaxin (GE33), optionally in the incorporation into collagen.