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公开(公告)号：US11564619B2
公开(公告)日：2023-01-31
申请号：US16224590
申请日：2018-12-18
发明人： Jeffrey C. Lotz , James Clayton Peacock, III , David S. Bradford , Stefan Dudli , Sergey G. Magnitsky
IPC分类号： A61B5/00 , G01R33/465 , G01R33/48 , G01R33/46 , G01R33/485 , A61B5/055 , G01R33/56 , G01R33/483
摘要： An MR Spectroscopy (MRS) system and approach is provided for measuring spectral information corresponding with propionic acid (PA), either alone or in combination with other measurements corresponding with other chemicals, to diagnose and/or monitor at least one of bacterial infection, such as associated with P. acnes, or conditions related thereto such as nociceptive pain associated with tissue acidity. An interfacing DDD-MRS signal processor receives output signals to produce a post-processed spectrum, with spectral regions corresponding with certain chemicals, including PA, then measured as biomarkers. A diagnostic processor derives a diagnostic value for each disc, and performs certain normalizations, based upon ratios of the spectral regions related to chemicals implicated in degenerative painful tissue pathology, such as PA and hypoxia markers of lactic acid (LA) and alanine (AL), and structural chemicals of proteoglycan (PG) and collagen or carbohydrate (CA).
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2.发明公开公开(公告)号：US20230355167A1
公开(公告)日：2023-11-09
申请号：US18160995
申请日：2023-01-27
发明人： Jeffrey C. Lotz , James Clayton Peacock, III , David S. Bradford , Stefan Dudli , Sergey G. Magnitsky
IPC分类号： A61B5/00 , A61B5/055 , G01R33/465 , G01R33/48 , G01R33/56 , G01R33/483 , G01R33/46 , G01R33/485
CPC分类号： A61B5/4514 , A61B5/055 , A61B5/412 , A61B5/4566 , G01R33/465 , G01R33/4828 , G01R33/5608 , G01R33/483 , G01R33/46 , G01R33/485
摘要： An MR Spectroscopy (MRS) system and approach is provided for measuring spectral information corresponding with propionic acid (PA), either alone or in combination with other measurements corresponding with other chemicals, to diagnose and/or monitor at least one of bacterial infection, such as associated with P. acnes, or conditions related thereto such as nociceptive pain associated with tissue acidity. An interfacing DDD-MRS signal processor receives output signals to produce a post-processed spectrum, with spectral regions corresponding with certain chemicals, including PA, then measured as biomarkers. A diagnostic processor derives a diagnostic value for each disc, and performs certain normalizations, based upon ratios of the spectral regions related to chemicals implicated in degenerative painful tissue pathology, such as PA and hypoxia markers of lactic acid (LA) and alanine (AL), and structural chemicals of proteoglycan (PG) and collagen or carbohydrate (CA).
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公开(公告)号：US11096603B2
公开(公告)日：2021-08-24
申请号：US15866312
申请日：2018-01-09
IPC分类号： A61B5/055 , G01R33/44 , A61B5/00 , G01R33/20 , G01R33/54 , G01N24/08 , G01R33/483 , G01R33/48 , G01R33/46 , G01R33/00 , G01N33/68 , G01R33/465 , G01R33/485
摘要： NMR spectroscopy is performed on intervertebral disc tissue. Extent of degeneration is determined based on the NMR spectroscopy. Correlation between NMR spectral regions and at least one of tissue degeneration and pain are made. Accordingly, NMR spectroscopy is used to determine location and/or extent of at least one of degeneration or pain associated with a region of tissue, such as for example in particular disc degeneration, or discogenic pain. NMR spectral peak ratios, such as between N-Acetyl/cho and cho/carb, are readily acquired and analyzed to predict degree of tissue degeneration and/or pain for: tissue samples using HR-MAS spectroscopy; and larger portions of anatomy such as joint segments such as a spine, using clinical 3T MRI systems with surface head or knee coils; and tissue regions such as discs within spines of living patients using 3T MRI systems with a surface spine coil, thus providing a completely non-invasive diagnostic toolset and method to image and localize degeneration and/or pain.
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公开(公告)号：US10272271B2
公开(公告)日：2019-04-30
申请号：US14540017
申请日：2014-11-12
摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.
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公开(公告)号：US20220142498A1
公开(公告)日：2022-05-12
申请号：US17372103
申请日：2021-07-09
IPC分类号： A61B5/055 , G01R33/44 , G01R33/20 , G01R33/54 , A61B5/00 , G01N24/08 , G01R33/483 , G01R33/48 , G01R33/46 , G01R33/00 , G01N33/68
摘要： A completely non-invasive diagnostic toolset and method to image and localize degeneration and/or pain. Extent of degeneration is determined based on NMR spectroscopy of intervertebral disc tissue. Correlation between NMR spectral regions and at least one of tissue degeneration and pain are made. Accordingly, NMR spectroscopy is used to determine location and/or extent of at least one of degeneration or pain associated with a region of tissue, such as for example in particular disc degeneration, or discogenic pain. NMR spectral peak ratios, such as between N-Acetyl/cho and cho/carb, are acquired and analyzed to predict degree of tissue degeneration and/or pain for: tissue samples using HR-MAS spectroscopy; and larger portions of anatomy such as joint segments such as a spine, using clinical 3T MRI systems with surface head or knee coils; and tissue regions such as discs within spines of living patients using 3T MRI systems with a surface spine coil.
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公开(公告)号：US20210339054A1
公开(公告)日：2021-11-04
申请号：US17337981
申请日：2021-06-03
摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.
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公开(公告)号：US11052267B2
公开(公告)日：2021-07-06
申请号：US16161025
申请日：2018-10-15
摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.
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8.发明申请公开(公告)号：US20190307393A1
公开(公告)日：2019-10-10
申请号：US16224590
申请日：2018-12-18
发明人： Jeffrey C. Lotz , James Clayton Peacock, III , David S. Bradford , Stefan Dudli , Sergey G. Magnitsky
IPC分类号： A61B5/00 , A61B5/055 , G01R33/465 , G01R33/56 , G01R33/48
摘要： An MR Spectroscopy (MRS) system and approach is provided for measuring spectral information corresponding with propionic acid (PA), either alone or in combination with other measurements corresponding with other chemicals, to diagnose and/or monitor at least one of bacterial infection, such as associated with P. acnes, or conditions related thereto such as nociceptive pain associated with tissue acidity. An interfacing DDD-MRS signal processor receives output signals to produce a post-processed spectrum, with spectral regions corresponding with certain chemicals, including PA, then measured as biomarkers. A diagnostic processor derives a diagnostic value for each disc, and performs certain normalizations, based upon ratios of the spectral regions related to chemicals implicated in degenerative painful tissue pathology, such as PA and hypoxia markers of lactic acid (LA) and alanine (AL), and structural chemicals of proteoglycan (PG) and collagen or carbohydrate (CA).
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公开(公告)号：US20190118005A1
公开(公告)日：2019-04-25
申请号：US16161025
申请日：2018-10-15
IPC分类号： A61N7/02
摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.
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公开(公告)号：US10123759B2
公开(公告)日：2018-11-13
申请号：US14850945
申请日：2015-09-10
发明人： David S. Bradford , Jeffrey C. Lotz
IPC分类号： A61B6/00 , A61K49/00 , A61B5/00 , A61N7/02 , A61B18/14 , A61K51/10 , A61M5/00 , A61M5/172 , A61B18/00
摘要： Pain factors are labeled with targeted agents or markers delivered into the body. The labeled pain factors are imaged with appropriate imaging tools in a manner allowing selective identification and localization of areas of pain source or transmission. The labeled pain factors allow spatial differentiation in the imaging sufficient to specify the location of the pain so as to drive therapeutic decisions and techniques in order to treat the pain. Pain factors labeled and imaged in this manner may include one or more of nerve factors, blood vessel factors, cellular factors, and inflammation factors. Labeled markers may include for example radioactive materials (e.g. tritiated or iodinated molecules) or other materials such as metal (e.g. gold) nanoparticles. Intermediary binding materials may be used, such as for example bi-specific antibodies.
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