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    MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs
    4.
    发明授权
    MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs 有权

    公开(公告)号：US10285622B2

    公开(公告)日：2019-05-14

    申请号：US15669584

    申请日：2017-08-04

    申请人： NOCIMED, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane ,  Jeffrey C. Lotz

    IPC分类号： A61B5/05 ,  A61B5/00 ,  A61B5/055 ,  G01R33/485

    摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.

    BACK PAIN TREATMENT USING MICROWAVE SOURCES
    5.
    发明申请
    BACK PAIN TREATMENT USING MICROWAVE SOURCES 审中-公开

    公开(公告)号：US20190118005A1

    公开(公告)日：2019-04-25

    申请号：US16161025

    申请日：2018-10-15

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will Nau ,  David S. Bradford

    IPC分类号： A61N7/02

    摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.

    Systems, compositions, and methods for local imaging and treatment of pain
    6.
    发明授权
    Systems, compositions, and methods for local imaging and treatment of pain 有权

    公开(公告)号：US10123759B2

    公开(公告)日：2018-11-13

    申请号：US14850945

    申请日：2015-09-10

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： David S. Bradford ,  Jeffrey C. Lotz

    IPC分类号： A61B6/00 ,  A61K49/00 ,  A61B5/00 ,  A61N7/02 ,  A61B18/14 ,  A61K51/10 ,  A61M5/00 ,  A61M5/172 ,  A61B18/00

    摘要： Pain factors are labeled with targeted agents or markers delivered into the body. The labeled pain factors are imaged with appropriate imaging tools in a manner allowing selective identification and localization of areas of pain source or transmission. The labeled pain factors allow spatial differentiation in the imaging sufficient to specify the location of the pain so as to drive therapeutic decisions and techniques in order to treat the pain. Pain factors labeled and imaged in this manner may include one or more of nerve factors, blood vessel factors, cellular factors, and inflammation factors. Labeled markers may include for example radioactive materials (e.g. tritiated or iodinated molecules) or other materials such as metal (e.g. gold) nanoparticles. Intermediary binding materials may be used, such as for example bi-specific antibodies.

    IMPLANTABLE THERMAL TREATMENT METHOD AND APPARATUS
    8.
    发明申请
    IMPLANTABLE THERMAL TREATMENT METHOD AND APPARATUS 有权
    可植入热处理方法和装置

    公开(公告)号：US20140288544A1

    公开(公告)日：2014-09-25

    申请号：US14197107

    申请日：2014-03-04

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Chris J. Diederich ,  Jeffrey C. Lotz ,  William H. Nau, JR. ,  David S. Bradford

    IPC分类号： A61B18/04

    CPC分类号： A61B18/04 ,  A61B8/56 ,  A61B2017/00092 ,  A61B2017/00101 ,  A61B2017/00261 ,  A61B2018/00339 ,  A61B2090/374 ,  A61N7/00 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0078

    摘要： A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.

    摘要翻译： 提供了一种长期植入式超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。 将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。 用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。 各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，这些范围通过诸如体内椎间盘的预应力组织显着影响。 特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现了其他响应而没有明显的重塑。

    THERMAL ENERGY DELIVERY SYSTEMS AND METHODS FOR HEATING A VERTEBRAL BODY
    10.
    发明申请
    THERMAL ENERGY DELIVERY SYSTEMS AND METHODS FOR HEATING A VERTEBRAL BODY 有权

    公开(公告)号：US20210339054A1

    公开(公告)日：2021-11-04

    申请号：US17337981

    申请日：2021-06-03

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will Nau ,  David S. Bradford

    IPC分类号： A61N7/02 ,  A61N7/00 ,  A61B17/00 ,  A61B18/04 ,  A61B90/00

    摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.