公开(公告)号：US20080118782A1

公开(公告)日：2008-05-22

申请号：US12020459

申请日：2008-01-25

申请人： ADAM HELLER ,  Nicholas Mano ,  Hyug-Han Kim ,  Yongchao Zhang ,  Fei Mao ,  Ting Chen ,  Scott Barton

发明人： ADAM HELLER ,  Nicholas Mano ,  Hyug-Han Kim ,  Yongchao Zhang ,  Fei Mao ,  Ting Chen ,  Scott Barton

IPC分类号： H01M8/16

CPC分类号： H01M8/16 ,  C12Q1/26 ,  C12Q1/32 ,  G01N33/723 ,  Y02E60/527

摘要： A fuel cell is provided with an anode and a cathode. The anode is in electrical communication with an anode enzyme and the cathode is in electrical communication with a cathode enzyme. The anode enzyme is preferably an oxidase or a dehydrogenase. The cathode enzyme is a copper-containing enzyme, such as a lacasse, an ascorbate oxidase, a ceruloplasmine, or a bilirubin oxidase. Preferably, the cathode enzyme is operable under physiological conditions. Redox polymers serve to wire the anode enzyme to the anode and the cathode enzyme to the cathode. The fuel cell can be very small in size because it does not require a membrane, seal, or case. The fuel cell can be used in connection with a biological system, such as a human, as it may operate at physiological conditions. By virtue of its size and operability at physiological conditions, the fuel cell is of particular interest for applications calling for a power source implanted in a human body, such as a variety of medical applications.

摘要翻译： 燃料电池设有阳极和阴极。 阳极与阳极酶电连通，阴极与阴极酶电连通。 阳极酶优选为氧化酶或脱氢酶。 阴极酶是含铜酶，例如lacasse，抗坏血酸氧化酶，血清白蛋白或胆红素氧化酶。 优选地，阴极酶在生理条件下是可操作的。 氧化还原聚合物用于将阳极酶连接到阳极，阴极酶连接到阴极。 燃料电池的尺寸可以非常小，因为它不需要膜，密封件或外壳。 燃料电池可以与诸如人类的生物系统结合使用，因为其可以在生理条件下操作。 由于其在生理条件下的尺寸和可操作性，燃料电池对于要求植入人体的电源（例如各种医疗应用）的应用是特别有意义的。

公开(公告)号：US07368190B2

公开(公告)日：2008-05-06

申请号：US10427113

申请日：2003-05-01

申请人： Adam Heller ,  Nicholas Mano ,  Hyug-Han Kim ,  Yongchao Zhang ,  Fei Mao ,  Ting Chen ,  Scott Calabrese Barton

发明人： Adam Heller ,  Nicholas Mano ,  Hyug-Han Kim ,  Yongchao Zhang ,  Fei Mao ,  Ting Chen ,  Scott Calabrese Barton

IPC分类号： H01M8/16

CPC分类号： H01M8/16 ,  C12Q1/26 ,  C12Q1/32 ,  G01N33/723 ,  Y02E60/527

摘要： A fuel cell is provided with an anode and a cathode. The anode is in electrical communication with an anode enzyme and the cathode is in electrical communication with a cathode enzyme. The anode enzyme is preferably an oxidase or a dehydrogenase. The cathode enzyme is a copper-containing enzyme, such as a laccase, an ascorbate oxidase, a ceruloplasmine, or a bilirubin oxidase. Preferably, the cathode enzyme is operable under physiological conditions. Redox polymers serve to wire the anode enzyme to the anode and the cathode enzyme to the cathode. The fuel cell can be very small in size because it does not require a membrane, seal, or case. The fuel cell can be used in connection with a biological system, such as a human, as it may operate at physiological conditions. By virtue of its size and operability at physiological conditions, the fuel cell is of particular interest for applications calling for a power source implanted in a human body, such as a variety of medical applications.

摘要翻译： 燃料电池设有阳极和阴极。 阳极与阳极酶电连通，阴极与阴极酶电连通。 阳极酶优选为氧化酶或脱氢酶。 阴极酶是含铜酶，例如漆酶，抗坏血酸氧化酶，血清白蛋白或胆红素氧化酶。 优选地，阴极酶在生理条件下是可操作的。 氧化还原聚合物用于将阳极酶连接到阳极，阴极酶连接到阴极。 燃料电池的尺寸可以非常小，因为它不需要膜，密封件或外壳。 燃料电池可以与诸如人类的生物系统结合使用，因为其可以在生理条件下操作。 由于其在生理条件下的尺寸和可操作性，燃料电池对于要求植入人体的电源（例如各种医疗应用）的应用是特别有意义的。

公开(公告)号：US20080044721A1

公开(公告)日：2008-02-21

申请号：US10427113

申请日：2003-05-01

申请人： Adam Heller ,  Nicholas Mano ,  Hyug-Han Kim ,  Yongchao Zhang ,  Fei Mao ,  Ting Chen ,  Scott Calabrese Barton

发明人： Adam Heller ,  Nicholas Mano ,  Hyug-Han Kim ,  Yongchao Zhang ,  Fei Mao ,  Ting Chen ,  Scott Calabrese Barton

IPC分类号： H01M4/90 ,  C12Q1/00

CPC分类号： H01M8/16 ,  C12Q1/26 ,  C12Q1/32 ,  G01N33/723 ,  Y02E60/527

摘要： A fuel cell is provided with an anode and a cathode. The anode is in electrical communication with an anode enzyme and the cathode is in electrical communication with a cathode enzyme. The anode enzyme is preferably an oxidase or a dehydrogenase. The cathode enzyme is a copper-containing enzyme, such as a laccase, an ascorbate oxidase, a ceruloplasmine, or a bilirubin oxidase. Preferably, the cathode enzyme is operable under physiological conditions. Redox polymers serve to wire the anode enzyme to the anode and the cathode enzyme to the cathode. The fuel cell can be very small in size because it does not require a membrane, seal, or case. The fuel cell can be used in connection with a biological system, such as a human, as it may operate at physiological conditions. By virtue of its size and operability at physiological conditions, the fuel cell is of particular interest for applications calling for a power source implanted in a human body, such as a variety of medical applications.

摘要翻译： 燃料电池设有阳极和阴极。 阳极与阳极酶电连通，阴极与阴极酶电连通。 阳极酶优选为氧化酶或脱氢酶。 阴极酶是含铜酶，例如漆酶，抗坏血酸氧化酶，血清白蛋白或胆红素氧化酶。 优选地，阴极酶在生理条件下是可操作的。 氧化还原聚合物用于将阳极酶连接到阳极，阴极酶连接到阴极。 燃料电池的尺寸可以非常小，因为它不需要膜，密封件或外壳。 燃料电池可以与诸如人类的生物系统结合使用，因为其可以在生理条件下操作。 由于其在生理条件下的尺寸和可操作性，燃料电池对于要求植入人体的电源（例如各种医疗应用）的应用是特别有意义的。

公开(公告)号：US08759055B2

公开(公告)日：2014-06-24

申请号：US12020459

申请日：2008-01-25

申请人： Adam Heller ,  Nicholas Mano ,  Hyug-Han Kim ,  Yongchao Zhang ,  Fei Mao ,  Ting Chen ,  Scott C. Barton

发明人： Adam Heller ,  Nicholas Mano ,  Hyug-Han Kim ,  Yongchao Zhang ,  Fei Mao ,  Ting Chen ,  Scott C. Barton

IPC分类号： C12N11/18 ,  C12Q1/26 ,  C12Q1/32 ,  G01N33/72 ,  H01M8/16

CPC分类号： H01M8/16 ,  C12Q1/26 ,  C12Q1/32 ,  G01N33/723 ,  Y02E60/527

摘要： A fuel cell is provided with an anode and a cathode. The anode is in electrical communication with an anode enzyme and the cathode is in electrical communication with a cathode enzyme. The anode enzyme is preferably an oxidase or a dehydrogenase. The cathode enzyme is a copper-containing enzyme, such as a lacasse, an ascorbate oxidase, a ceruloplasmine, or a bilirubin oxidase. Preferably, the cathode enzyme is operable under physiological conditions. Redox polymers serve to wire the anode enzyme to the anode and the cathode enzyme to the cathode. The fuel cell can be very small in size because it does not require a membrane, seal, or case. The fuel cell can be used in connection with a biological system, such as a human, as it may operate at physiological conditions. By virtue of its size and operability at physiological conditions, the fuel cell is of particular interest for applications calling for a power source implanted in a human body, such as a variety of medical applications.

摘要翻译： 燃料电池设有阳极和阴极。 阳极与阳极酶电连通，阴极与阴极酶电连通。 阳极酶优选为氧化酶或脱氢酶。 阴极酶是含铜酶，例如lacasse，抗坏血酸氧化酶，血清白蛋白或胆红素氧化酶。 优选地，阴极酶在生理条件下是可操作的。 氧化还原聚合物用于将阳极酶连接到阳极，阴极酶连接到阴极。 燃料电池的尺寸可以非常小，因为它不需要膜，密封件或外壳。 燃料电池可以与诸如人类的生物系统结合使用，因为其可以在生理条件下操作。 由于其在生理条件下的尺寸和可操作性，燃料电池对于要求植入人体的电源（例如各种医疗应用）的应用是特别有意义的。

公开(公告)号：US20090095642A1

公开(公告)日：2009-04-16

申请号：US12102749

申请日：2008-04-14

申请人： Tianmei Ouyang ,  Zenghe Liu ,  John LaTour ,  Ting Chen ,  Lam N. Tran ,  Benjamin Feldman ,  Fei Mao ,  Adam Heller

发明人： Tianmei Ouyang ,  Zenghe Liu ,  John LaTour ,  Ting Chen ,  Lam N. Tran ,  Benjamin Feldman ,  Fei Mao ,  Adam Heller

IPC分类号： C12Q1/32 ,  G01N27/26

CPC分类号： C07F1/005 ,  C07F15/0026

摘要： Enzyme-based electrochemical sensors comprising transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators and include substituted or unsubstituted pyridyl-imidazole ligands. Transition metal complexes attached to polymeric backbones are also described.

摘要翻译： 描述了包含铁，钴，钌，锇和钒的过渡金属络合物的基于酶的电化学传感器。 过渡金属络合物可用作氧化还原介体，包括取代或未取代的吡啶基 - 咪唑配体。 还描述了连接到聚合物主链上的过渡金属络合物。

公开(公告)号：US20100288633A1

公开(公告)日：2010-11-18

申请号：US12843634

申请日：2010-07-26

申请人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

发明人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

IPC分类号： G01N27/31

CPC分类号： G01N27/3271

摘要： A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes at least one layer of a polyanionic or polycationic material. The assembled layers of the membrane are typically disposed in an alternating manner. The sensor also optionally includes a biocompatible membrane.

摘要翻译： 包括感测层的传感器设置在电极或光栅上，以及设置在感测层上的逐层组装的质量传输限制膜。 膜包括至少一层聚阴离子或聚阳离子材料。 膜的组装层通常以交替的方式设置。 传感器还可选地包括生物相容膜。

公开(公告)号：US07666284B2

公开(公告)日：2010-02-23

申请号：US10862932

申请日：2004-06-07

申请人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

发明人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

IPC分类号： G01N27/327

CPC分类号： G01N27/3271

摘要： A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes at least one layer of a polyanionic or polycationic material. The assembled layers of the membrane are typically disposed in an alternating manner. The sensor also optionally includes a biocompatible membrane.

摘要翻译： 包括感测层的传感器设置在电极或光栅上，以及设置在感测层上的逐层组装的质量传输限制膜。 膜包括至少一层聚阴离子或聚阳离子材料。 膜的组装层通常以交替的方式设置。 传感器还可选地包括生物相容膜。

公开(公告)号：US06746582B2

公开(公告)日：2004-06-08

申请号：US09854310

申请日：2001-05-11

申请人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

发明人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

IPC分类号： G01N27327

CPC分类号： G01N27/3271

摘要： A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes at least one layer of a polyanionic or polycationic material. The assembled layers of the membrane are typically disposed in an alternating manner. The sensor also optionally includes a biocompatible membrane.

摘要翻译： 包括感测层的传感器设置在电极或光栅上，以及设置在感测层上的逐层组装的质量传输限制膜。 膜包括至少一层聚阴离子或聚阳离子材料。 膜的组装层通常以交替的方式设置。 传感器还可选地包括生物相容膜。

公开(公告)号：US20100023270A1

公开(公告)日：2010-01-28

申请号：US12421619

申请日：2009-04-09

申请人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

发明人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

IPC分类号： G06F19/00 ,  G01N33/48

CPC分类号： G01N27/3271

摘要： A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes at least one layer of a polyanionic or polycationic material. The assembled layers of the membrane are typically disposed in an alternating manner. The sensor also optionally includes a biocompatible membrane.

摘要翻译： 包括感测层的传感器设置在电极或光栅上，以及设置在感测层上的逐层组装的质量传输限制膜。 膜包括至少一层聚阴离子或聚阳离子材料。 膜的组装层通常以交替的方式设置。 传感器还可选地包括生物相容膜。

公开(公告)号：US20090308743A1

公开(公告)日：2009-12-17

申请号：US12544689

申请日：2009-08-20

申请人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

发明人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

IPC分类号： G01N27/403 ,  C12M1/00

CPC分类号： G01N27/3271

摘要： A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes at least one layer of a polyanionic or polycationic material. The assembled layers of the membrane are typically disposed in an alternating manner. The sensor also optionally includes a biocompatible membrane.

摘要翻译： 包括感测层的传感器设置在电极或光栅上，以及设置在感测层上的逐层组装的质量传输限制膜。 膜包括至少一层聚阴离子或聚阳离子材料。 膜的组装层通常以交替的方式设置。 传感器还可选地包括生物相容膜。