公开(公告)号：US20160310010A1

公开(公告)日：2016-10-27

申请号：US15038029

申请日：2014-12-08

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Malini Olivo ,  Jun Hui Ho ,  Dinish Unnimadhava Kurup Soudamini Amma ,  Chi Lok Wong ,  Ghayathri Balasundaram

IPC: A61B5/00 ,  A61K49/22 ,  G01N33/483 ,  A61B8/08

CPC classification number: A61B5/0095 ,  A61B8/481 ,  A61K49/003 ,  A61K49/0036 ,  A61K49/0093 ,  A61K49/22 ,  G01N33/4833

Abstract: A method of imaging living tissue is provided. The method includes introducing a photoacoustic contrast agent comprising or consisting of a photosensitizer into living tissue; and obtaining an image of the living tissue by photoacoustic imaging. Use of a photoacoustic contrast agent comprising or consisting of a photosensitizer in photoacoustic imaging is also provided.

Abstract translation: 提供了一种生物组织成像方法。 该方法包括将包含光敏剂或由光敏剂组成的光声造影剂引入活组织; 并通过光声成像获得活体组织的图像。 还提供了光声成像中包含光敏剂或由光敏剂组成的光声造影剂的使用。

公开(公告)号：US10690595B2

公开(公告)日：2020-06-23

申请号：US16319155

申请日：2017-07-18

Applicant: Agency for Science, Technology and Research

Inventor： Chi Lok Wong ,  Malini Olivo

IPC: G01J4/00 ,  G01N21/552 ,  G01N21/21 ,  G01J3/447 ,  G01N33/543 ,  G01J3/02 ,  G01N21/05 ,  G01N21/77

Abstract: Various embodiments may provide an optical sensing device based on surface plasmon resonance (SPR). The optical sensing device may include an optical arrangement configured to provide a first polarization light beam and a second polarization light beam, and a first optical member including a sensing surface, the first optical member configured to receive the first and second polarization light beams and reflect the first and second polarization light beams at the sensing surface. The optical sensing device may further include a second optical member arranged to receive the reflected first and second polarization light beams from the first optical member and configured to separate the reflected first and second polarization light beams in a first direction and a second direction, respectively. The optical device may additionally include a detector arrangement configured to detect the reflected first and second polarization light beams from the second optical member.

公开(公告)号：US20190285542A1

公开(公告)日：2019-09-19

申请号：US16319155

申请日：2017-07-18

Applicant: Agency for Science, Technology and Research

Inventor： Chi Lok Wong ,  Malini Olivo

IPC: G01N21/552 ,  G01N21/21

Abstract: Various embodiments may provide an optical sensing device based on surface plasmon resonance (SPR). The optical sensing device may include an optical arrangement configured to provide a first polarization light beam and a second polarization light beam, and a first optical member including a sensing surface, the first optical member configured to receive the first and second polarization light beams and reflect the first and second polarization light beams at the sensing surface. The optical sensing device may further include a second optical member arranged to receive the reflected first and second polarization light beams from the first optical member and configured to separate the reflected first and second polarization light beams in a first direction and a second direction, respectively. The optical device may additionally include a detector arrangement configured to detect the reflected first and second polarization light beams from the second optical member.

公开(公告)号：US10398315B2

公开(公告)日：2019-09-03

申请号：US15038029

申请日：2014-12-08

Applicant: Agency for Science, Technology and Research

Inventor： Malini Olivo ,  Jun Hui Ho ,  Dinish Unnimadhava Kurup Soudamini Amma ,  Chi Lok Wong ,  Ghayathri Balasundaram

IPC: A61B5/00 ,  A61B8/08 ,  A61K49/00 ,  A61K49/22 ,  G01N33/483

Abstract: A method of imaging living tissue is provided. The method includes introducing a photoacoustic contrast agent comprising or consisting of a photosensitizer into living tissue; and obtaining an image of the living tissue by photoacoustic imaging. Use of a photoacoustic contrast agent comprising or consisting of a photosensitizer in photoacoustic imaging is also provided.

公开(公告)号：US10107748B2

公开(公告)日：2018-10-23

申请号：US15033981

申请日：2014-11-04

Applicant: Agency for Science, Technology and Research

Inventor： Chi Lok Wong ,  Malini Olivo

IPC: G01N21/55 ,  G01N21/552 ,  G01N21/21

Abstract: An optical sensing device is provided, including a first polarizer, a second polarizer, wherein the first polarizer and the second polarizer have respective transmission axes aligned in orthogonal directions, an SPR sensor arrangement including an SPR sensing surface, the SPR sensor arrangement arranged to receive an incident light beam passed through a polarizer to be reflected at the SPR sensing surface and transmitted through a second polarizer to provide a transmitted light beam, a detector arrangement configured to detect the transmitted light beam, the transmitted light beam including a sensing signal and a reference signal, and a processor electrically coupled to the detector arrangement, the processor configured to perform a subtraction operation between the sensing signal and the reference signal. The optical sensing is based on a differential measurement scheme. The subtraction between the sensing signal and the reference signal cancels the common path noise and enhances the sensor resolution.

公开(公告)号：US20230333011A1

公开(公告)日：2023-10-19

申请号：US18024873

申请日：2021-09-15

Applicant: Agency for Science, Technology and Research

Inventor： Kapil Dev ,  Ruochong Zhang ,  Chi Lok Wong ,  Shuyan Zhang ,  Dinish Unnimadhava Kurup Soudamini Amma ,  Malini Carolene Devapiriyai Olivo

IPC: G01N21/3563 ,  G01N21/64 ,  G01N21/84 ,  G01N21/359

CPC classification number: G01N21/3563 ,  G01N21/6456 ,  G01N21/84 ,  G01N21/359 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2021/8466

Abstract: An optical system for imaging. The optical system includes light emitting diodes to provide light of predetermined wavelengths. The optical system further includes a charge-coupled device to receive the light emitted by one or more light emitting diodes and reflected by an object for fluorescence imaging of the object. The optical system additionally includes a broadband light source to provide broadband light. Furthermore, the optical system includes a spectrometer to receive the broadband light emitted by the broadband light source and reflected by the object for visible-near infrared-shortwave infrared spectroscopy of the object. Additionally, the optical system includes a hyperspectral camera to receive the broadband light emitted by the broadband light source and reflected by the object for hyperspectral imaging of the object as well as a controller coupled to the light emitting diodes, the broadband light source, the charge-coupled device, the spectrometer and the hyperspectral camera.

公开(公告)号：US20160313246A1

公开(公告)日：2016-10-27

申请号：US15033981

申请日：2014-11-04

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Chi Lok Wong ,  Malini Olivo

IPC: G01N21/552

CPC classification number: G01N21/553 ,  G01N21/21 ,  G01N2201/0683 ,  G01N2201/12

Abstract: An optical sensing device is provided, including a first polariser, a second polariser, wherein the first polariser and the second polariser have respective transmission axes aligned in orthogonal directions, an SPR sensor arrangement including an SPR sensing surface, the SPR sensor arrangement arranged to receive an incident light beam passed through a polariser to be reflected at the SPR sensing surface and transmitted through a second polariser to provide a transmitted light beam, a detector arrangement configured to detect the transmitted light beam, the transmitted light beam including a sensing signal and a reference signal, and a processor electrically coupled to the detector arrangement, the processor configured to perform a subtraction operation between the sensing signal and the reference signal. The optical sensing is based on a differential measurement scheme. The subtraction between the sensing signal and the reference signal cancels the common path noise and enhances the sensor resolution.

Abstract translation: 提供一种光学感测装置，包括第一偏振器，第二偏振器，其中第一偏振器和第二偏振器具有在正交方向上对准的相应透射轴，SPR传感器装置包括SPR感测表面，SPR传感器装置布置成接收 入射光束通过偏振器以在SPR感测表面反射并透射通过第二偏振器以提供透射光束，被配置为检测透射光束的检测器装置，包括感测信号的透射光束和 参考信号和电耦合到检测器装置的处理器，所述处理器被配置为执行感测信号和参考信号之间的减法运算。 光学感测是基于差分测量方案。 感测信号与参考信号之间的减法消除了公共路径噪声，提高了传感器的分辨率。