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公开(公告)号：US09587259B2
公开(公告)日：2017-03-07
申请号：US14467459
申请日：2014-08-25
Applicant: AJINOMOTO CO., INC.
Inventor： Fumi Shozui , Yoshinori Tajima
CPC classification number: C12P13/005 , C08G73/22 , C12N9/1029 , C12N9/88 , C12N15/70 , C12Y203/01118 , C12Y401/99
Abstract: The present invention provides a method for conveniently and inexpensively producing an amino-hydroxybenzoic acid-type compound such as 3-amino-4-hydroxybenzoic acid by utilizing Escherichia coli that is a bacterium commonly used for a production process by biosynthesis. Specifically, the present invention provides an Escherichia coli having an ability to produce 3-amino-4-hydroxybenzoic acid, which is modified to reduce an activity of N-hydroxyarylamine O-acetyltransferase (NhoA); a method for producing a 3-amino-4-hydroxybenzoic acid-type compound using such Escherichia coli; and the like.
Abstract translation: 本发明提供了通过利用作为通常用于通过生物合成的生产方法的细菌的大肠杆菌来方便和廉价地制备氨基 - 羟基苯甲酸型化合物如3-氨基-4-羟基苯甲酸的方法。 具体地说，本发明提供具有生产3-氨基-4-羟基苯甲酸的能力的大肠杆菌，其被修饰以降低N-羟基芳基胺O-乙酰基转移酶（NhoA）的活性; 使用这样的大肠杆菌生产3-氨基-4-羟基苯甲酸型化合物的方法; 等等。
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Patent Agency Ranking
公开(公告)号：US09447443B2
公开(公告)日：2016-09-20
申请号：US14547481
申请日：2014-11-19
Applicant: AJINOMOTO CO., INC.
Inventor： Fumi Shozui , Yoshinori Tajima , Keiichi Yokoyama
CPC classification number: C12P13/02 , C08G73/22 , C12N9/104 , C12P13/005 , Y02P20/52
Abstract: The present invention provides a method for conveniently and efficiently producing a 3-acetylamino-4-hydroxybenzoic acid-type compound that is a stable compound by a process using a microorganism. Specifically the present invention provides a microorganism having an ability to produce 3-amino-4-hydroxybenzoic acid, that is modified so as to increase an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde, wherein the microorganism is modified so as to increase an N-hydroxyarylamine O-acetyltransferase (NhoA) activity, as well as a method for producing the 3-acetylamino-4-hydroxybenzoic acid-type compound using such a microorganism.
Abstract translation: 本发明提供了通过使用微生物的方法方便有效地制备作为稳定化合物的3-乙酰氨基-4-羟基苯甲酸型化合物的方法。 具体地说，本发明提供具有生产3-氨基-4-羟基苯甲酸的能力的微生物，其被修饰以增加从磷酸二羟丙酮和天冬氨酸半醛形成3-氨基-4-羟基苯甲酸的活性，其中微生物 被修饰以增加N-羟基芳基胺O-乙酰基转移酶（NhoA）活性，以及使用这种微生物生产3-乙酰氨基-4-羟基苯甲酸型化合物的方法。
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公开(公告)号：US20150079644A1
公开(公告)日：2015-03-19
申请号：US14547481
申请日：2014-11-19
Applicant: AJINOMOTO CO., INC.
Inventor： Fumi Shozui , Yoshinori Tajima , Keiichi Yokoyama
CPC classification number: C12P13/02 , C08G73/22 , C12N9/104 , C12P13/005 , Y02P20/52
Abstract: The present invention provides a method for conveniently and efficiently producing a 3-acetylamino-4-hydroxybenzoic acid-type compound that is a stable compound by a process using a microorganism. Specifically the present invention provides a microorganism having an ability to produce 3-amino-4-hydroxybenzoic acid, that is modified so as to increase an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde, wherein the microorganism is modified so as to increase an N-hydroxyarylamine O-acetyltransferase (NhoA) activity, as well as a method for producing the 3-acetylamino-4-hydroxybenzoic acid-type compound using such a microorganism.
Abstract translation: 本发明提供了通过使用微生物的方法方便有效地制备作为稳定化合物的3-乙酰氨基-4-羟基苯甲酸型化合物的方法。 具体地说，本发明提供具有生产3-氨基-4-羟基苯甲酸的能力的微生物，其被修饰以增加从磷酸二羟丙酮和天冬氨酸半醛形成3-氨基-4-羟基苯甲酸的活性，其中微生物 被修饰以增加N-羟基芳基胺O-乙酰基转移酶（NhoA）活性，以及使用这种微生物生产3-乙酰氨基-4-羟基苯甲酸型化合物的方法。
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公开(公告)号：US20140364579A1
公开(公告)日：2014-12-11
申请号：US14467459
申请日：2014-08-25
Applicant: AJINOMOTO CO., INC.
Inventor： Fumi Shozui , Yoshinori Tajima
CPC classification number: C12P13/005 , C08G73/22 , C12N9/1029 , C12N9/88 , C12N15/70 , C12Y203/01118 , C12Y401/99
Abstract: The present invention provides a method for conveniently and inexpensively producing an amino-hydroxybenzoic acid-type compound such as 3-amino-4-hydroxybenzoic acid by utilizing Escherichia coli that is a bacterium commonly used for a production process by biosynthesis. Specifically, the present invention provides an Escherichia coli having an ability to produce 3-amino-4-hydroxybenzoic acid, which is modified to reduce an activity of N-hydroxyarylamine O-acetyltransferase (NhoA); a method for producing a 3-amino-4-hydroxybenzoic acid-type compound using such Escherichia coli; and the like.
Abstract translation: 本发明提供了通过利用作为通常用于通过生物合成的生产方法的细菌的大肠杆菌来方便和廉价地制备氨基 - 羟基苯甲酸型化合物如3-氨基-4-羟基苯甲酸的方法。 具体地说，本发明提供具有生产3-氨基-4-羟基苯甲酸的能力的大肠杆菌，其被修饰以降低N-羟基芳基胺O-乙酰基转移酶（NhoA）的活性; 使用这样的大肠杆菌生产3-氨基-4-羟基苯甲酸型化合物的方法; 等等。
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公开(公告)号：US09458289B2
公开(公告)日：2016-10-04
申请号：US14872727
申请日：2015-10-01
Applicant: Ajinomoto Co., Inc.
Inventor： Fumi Shozui , Ryotaro Nakaya , Takashi Ineyama , Keiichi Yokoyama
IPC: C08G63/02 , C08G63/685 , C08G63/78
CPC classification number: C08G63/6856 , C08G63/78
Abstract: Polyester compounds obtained by reaction of a compound represented by formula (1): (defined herein) with a compound represented by formula (2): (defined herein) exhibit high thermal resistance.
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公开(公告)号：US09458288B2
公开(公告)日：2016-10-04
申请号：US14872671
申请日：2015-10-01
Applicant: Ajinomoto Co., Inc.
Inventor： Fumi Shozui , Ryotaro Nakaya , Takashi Ineyama , Keiichi Yokoyama
IPC: C08G64/00 , C08G63/685 , C08G63/78 , C08G63/02
CPC classification number: C08G63/6856 , C08G63/78
Abstract: Polyester compounds obtained by reaction of a compound represented by formula (1): (defined herein) with a compound represented by formula (2): (defined herein) exhibit high thermal resistance.
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