公开(公告)号：US20150079644A1

公开(公告)日：2015-03-19

申请号：US14547481

申请日：2014-11-19

Applicant: AJINOMOTO CO., INC.

Inventor： Fumi Shozui ,  Yoshinori Tajima ,  Keiichi Yokoyama

IPC: C12P13/02 ,  C08G73/22

CPC classification number: C12P13/02 ,  C08G73/22 ,  C12N9/104 ,  C12P13/005 ,  Y02P20/52

Abstract: The present invention provides a method for conveniently and efficiently producing a 3-acetylamino-4-hydroxybenzoic acid-type compound that is a stable compound by a process using a microorganism. Specifically the present invention provides a microorganism having an ability to produce 3-amino-4-hydroxybenzoic acid, that is modified so as to increase an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde, wherein the microorganism is modified so as to increase an N-hydroxyarylamine O-acetyltransferase (NhoA) activity, as well as a method for producing the 3-acetylamino-4-hydroxybenzoic acid-type compound using such a microorganism.

Abstract translation: 本发明提供了通过使用微生物的方法方便有效地制备作为稳定化合物的3-乙酰氨基-4-羟基苯甲酸型化合物的方法。 具体地说，本发明提供具有生产3-氨基-4-羟基苯甲酸的能力的微生物，其被修饰以增加从磷酸二羟丙酮和天冬氨酸半醛形成3-氨基-4-羟基苯甲酸的活性，其中微生物 被修饰以增加N-羟基芳基胺O-乙酰基转移酶（NhoA）活性，以及​​使用这种微生物生产3-乙酰氨基-4-羟基苯甲酸型化合物的方法。

公开(公告)号：US08962296B2

公开(公告)日：2015-02-24

申请号：US13832260

申请日：2013-03-15

Applicant: Bridgestone Corporation ,  Ajinomoto Co., Inc.

Inventor： Yasuyuki Hayashi ,  Minako Harada ,  Saaya Takaoka ,  Yasuo Fukushima ,  Keiichi Yokoyama ,  Yosuke Nishio ,  Yoshinori Tajima ,  Yoko Mihara ,  Kunio Nakata

IPC: C12N9/88 ,  C12P21/06 ,  C12P19/34 ,  C12N15/00 ,  C12N1/20 ,  C12N1/00 ,  C12P5/02 ,  C07H21/04 ,  C07K1/00 ,  C12P5/00

CPC classification number: C12P5/007 ,  C12N9/88 ,  C12P5/00 ,  C12Y402/03027

Abstract: The present invention provides means useful for establishing an excellent isoprene monomer production system. Specifically, the present invention provides a polynucleotide of the following (a), (b), or (c): (a) a polynucleotide comprising (i) the nucleotide sequence represented by SEQ ID NO:1, or (ii) the nucleotide sequence consisting of the nucleotide residues at positions 133 to 1785 in the nucleotide sequence represented by SEQ ID NO:1; (b) a polynucleotide that comprises a nucleotide sequence having 90% or more identity to the nucleotide sequence of (i) or (ii) above, and encodes a protein having an isoprene synthase activity; or (c) a polynucleotide that hybridizes under a stringent condition with a polynucleotide consisting of a nucleotide sequence complementary to the nucleotide sequence of (i) or (ii) above, and encodes a protein having an isoprene synthase activity; and the like.

Abstract translation: 本发明提供了用于建立优异的异戊二烯单体生产系统的方法。 具体而言，本发明提供下述（a），（b）或（c）所示的多核苷酸：（a）包含（i）由SEQ ID NO：1表示的核苷酸序列的多核苷酸，或（ii） 由SEQ ID NO：1所示的核苷酸序列的133〜1785位核苷酸残基组成的序列; （b）包含与上述（i）或（ii）的核苷酸序列具有90％以上同一性的核苷酸序列的多核苷酸，并编码具有异戊二烯合酶活性的蛋白质; 或（c）在严格条件下与由上述（i）或（ii）的核苷酸序列互补的核苷酸序列组成的多核苷酸杂交的多核苷酸，并编码具有异戊二烯合酶活性的蛋白质; 等等。

公开(公告)号：US10463594B2

公开(公告)日：2019-11-05

申请号：US15399347

申请日：2017-01-05

Applicant: AJINOMOTO CO., INC.

Inventor： Keiichi Yokoyama ,  Eiko Oshimura ,  Masayo Date ,  Yukiko Umezawa

IPC: A61K8/66 ,  A61Q5/00 ,  A61Q5/04 ,  A61Q5/06 ,  C12N9/80 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q5/10 ,  A61K8/34 ,  A61K8/41 ,  A61K8/44

Abstract: A method for perming or coloring hair, in which hair is treated with a cosmetic composition including a protein-glutaminase and not including an alkaline substance. A method of enhancing hair-permeation of an active ingredient included in a cosmetic composition, in which a protein glutaminase is included in the cosmetic composition. The cosmetic composition does not include an alkaline substance, and the active ingredient is at least one of a hair perm agent and a hair coloring agent.

公开(公告)号：US09458289B2

公开(公告)日：2016-10-04

申请号：US14872727

申请日：2015-10-01

Applicant: Ajinomoto Co., Inc.

Inventor： Fumi Shozui ,  Ryotaro Nakaya ,  Takashi Ineyama ,  Keiichi Yokoyama

IPC: C08G63/02 ,  C08G63/685 ,  C08G63/78

CPC classification number: C08G63/6856 ,  C08G63/78

Abstract: Polyester compounds obtained by reaction of a compound represented by formula (1): (defined herein) with a compound represented by formula (2): (defined herein) exhibit high thermal resistance.

公开(公告)号：US09458288B2

公开(公告)日：2016-10-04

申请号：US14872671

申请日：2015-10-01

Applicant: Ajinomoto Co., Inc.

Inventor： Fumi Shozui ,  Ryotaro Nakaya ,  Takashi Ineyama ,  Keiichi Yokoyama

IPC: C08G64/00 ,  C08G63/685 ,  C08G63/78 ,  C08G63/02

CPC classification number: C08G63/6856 ,  C08G63/78

Abstract: Polyester compounds obtained by reaction of a compound represented by formula (1): (defined herein) with a compound represented by formula (2): (defined herein) exhibit high thermal resistance.

公开(公告)号：US09447443B2

公开(公告)日：2016-09-20

申请号：US14547481

申请日：2014-11-19

Applicant: AJINOMOTO CO., INC.

Inventor： Fumi Shozui ,  Yoshinori Tajima ,  Keiichi Yokoyama

IPC: C12P13/02 ,  C12P7/22 ,  C12P7/42 ,  C12N9/10 ,  C12P13/00 ,  C08G73/22

CPC classification number: C12P13/02 ,  C08G73/22 ,  C12N9/104 ,  C12P13/005 ,  Y02P20/52

Abstract: The present invention provides a method for conveniently and efficiently producing a 3-acetylamino-4-hydroxybenzoic acid-type compound that is a stable compound by a process using a microorganism. Specifically the present invention provides a microorganism having an ability to produce 3-amino-4-hydroxybenzoic acid, that is modified so as to increase an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde, wherein the microorganism is modified so as to increase an N-hydroxyarylamine O-acetyltransferase (NhoA) activity, as well as a method for producing the 3-acetylamino-4-hydroxybenzoic acid-type compound using such a microorganism.

Abstract translation: 本发明提供了通过使用微生物的方法方便有效地制备作为稳定化合物的3-乙酰氨基-4-羟基苯甲酸型化合物的方法。 具体地说，本发明提供具有生产3-氨基-4-羟基苯甲酸的能力的微生物，其被修饰以增加从磷酸二羟丙酮和天冬氨酸半醛形成3-氨基-4-羟基苯甲酸的活性，其中微生物 被修饰以增加N-羟基芳基胺O-乙酰基转移酶（NhoA）活性，以及​​使用这种微生物生产3-乙酰氨基-4-羟基苯甲酸型化合物的方法。