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公开(公告)号：US20140309135A1
公开(公告)日：2014-10-16
申请号：US14261953
申请日：2014-04-25
Applicant: AJINOMOTO CO., INC.
Inventor： Naoyuki FUKUCHI , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
IPC: C07D487/04 , G01N33/50 , G01N33/573 , G01N33/68 , C12Q1/48
CPC classification number: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
Abstract translation: 筛选具有降血糖作用的化合物的方法（以下称为“降血糖化合物”），含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说，可以列举一种能够将降血糖化合物 绑定到＆bgr 三聚GTP结合蛋白的亚单位，包含降血糖化合物的糖尿病治疗剂，其特征在于能够结合到该组合物上。 三聚GTP结合蛋白的亚基作为活性成分等
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公开(公告)号：US20130130277A1
公开(公告)日：2013-05-23
申请号：US13709798
申请日：2012-12-10
Applicant: AJINOMOTO CO., INC.
Inventor： Naoyuki FUKUCHI , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
IPC: C07D487/04 , G01N33/68
CPC classification number: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
Abstract translation: 筛选具有降血糖作用的化合物的方法（以下称为“降血糖化合物”），含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说，可以列举一种能够将降血糖化合物 与三聚GTP结合蛋白的β亚基结合，包括降血糖化合物的糖尿病治疗剂，其特征在于能够结合三聚体GTP结合蛋白的β亚基作为活性成分等。
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公开(公告)号：US20190137516A1
公开(公告)日：2019-05-09
申请号：US16239834
申请日：2019-01-04
Applicant: AJINOMOTO CO., INC.
Inventor： Takeshi Ikeuchi , Yuki Yano , Naoko Arashida , Rumi Nishimoto , Kazutaka Shimbo , Nobuhiro Kawai
Abstract: An evaluating method includes an evaluating step of evaluating future risk of developing Alzheimer's disease for a subject to be evaluated having mild cognitive impairment using a concentration value of at least one of α-ABA, Ala, Arg, Asn, Cit, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Cysteine, Taurine, bABA, Ethylglycine, Hypotaurine, 3-Me-His, 5-HydroxyTrp, aAiBA, and N8-Acetylspermidine in blood of the subject.
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公开(公告)号：US08772281B2
公开(公告)日：2014-07-08
申请号：US13709798
申请日：2012-12-10
Applicant: Ajinomoto Co., Inc.
Inventor： Naoyuki Fukuchi , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
CPC classification number: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
Abstract translation: 筛选具有降血糖作用的化合物的方法（以下称为“降血糖化合物”），含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说，可以列举一种能够将降血糖化合物 绑定到＆bgr 三聚GTP结合蛋白的亚单位，包含降血糖化合物的糖尿病治疗剂，其特征在于能够结合到该组合物上。 三聚GTP结合蛋白的亚基作为活性成分等
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