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公开(公告)号：US20130130277A1
公开(公告)日：2013-05-23
申请号：US13709798
申请日：2012-12-10
Applicant: AJINOMOTO CO., INC.
Inventor： Naoyuki FUKUCHI , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
IPC: C07D487/04 , G01N33/68
CPC classification number: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
Abstract translation: 筛选具有降血糖作用的化合物的方法（以下称为“降血糖化合物”），含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说，可以列举一种能够将降血糖化合物 与三聚GTP结合蛋白的β亚基结合，包括降血糖化合物的糖尿病治疗剂，其特征在于能够结合三聚体GTP结合蛋白的β亚基作为活性成分等。
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Patent Agency Ranking
公开(公告)号：US09290487B2
公开(公告)日：2016-03-22
申请号：US14268323
申请日：2014-05-02
Applicant: Ajinomoto Co., Inc.
Inventor： Tadakiyo Nakagawa , Kayo Matsumoto , Sen Takeshita , Tomomi Yoshida , Munetaka Tokumasu , Hiroki Inoue , Kaori Kobayashi
IPC: C07D413/12 , C07D405/12 , C07D207/16 , C07D403/12 , C07D409/12 , C07D307/80 , A61K31/343 , A61K31/397 , A61K31/401 , A61K31/4025 , A61K31/404 , A61K31/427 , A61K31/536 , C07D307/79
CPC classification number: C07D413/12 , A61K31/343 , A61K31/397 , A61K31/401 , A61K31/4025 , A61K31/404 , A61K31/427 , A61K31/536 , C07D207/16 , C07D307/79 , C07D307/80 , C07D403/12 , C07D405/12 , C07D409/12
Abstract: Provided is a compound represented by the following general formula (I), or a pharmaceutically acceptable salt thereof. This novel compound has a glycogen-synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe. In the formula, Ar is an aromatic carbocyclic ring or a heterocyclic ring; and Ar2 is represented by any one of the following rings and the like.
Abstract translation: 提供由以下通式（I）表示的化合物或其药学上可接受的盐。 这种新型化合物具有糖原合成酶的活化能力，但能够将受体PPAR活性降低到很低的程度。 在该式中，Ar是芳香族碳环或杂环; Ar 2由以下任一个环等表示。
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公开(公告)号：US20140336376A1
公开(公告)日：2014-11-13
申请号：US14268323
申请日：2014-05-02
Applicant: Ajinomoto Co., Inc.
Inventor： Tadakiyo NAKAGAWA , Kayo Matsumoto , Sen Takeshita , Tomomi Yoshida , Munetaka Tokumasu , Hiroki Inoue , Kaori Kobayashi
IPC: C07D413/12 , C07D307/80 , C07D403/12 , C07D409/12 , C07D405/12 , C07D207/16
CPC classification number: C07D413/12 , A61K31/343 , A61K31/397 , A61K31/401 , A61K31/4025 , A61K31/404 , A61K31/427 , A61K31/536 , C07D207/16 , C07D307/79 , C07D307/80 , C07D403/12 , C07D405/12 , C07D409/12
Abstract: Provided is a compound represented by the following general formula (I), or a pharmaceutically acceptable salt thereof. This novel compound has a glycogen-synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe. In the formula, Ar is an aromatic carbocyclic ring or a heterocyclic ring; and Ar2 is represented by any one of the following rings and the like.
Abstract translation: 提供由以下通式（I）表示的化合物或其药学上可接受的盐。 这种新型化合物具有糖原合成酶的活化能力，但能够将受体PPAR活性降低到很低的程度。 在该式中，Ar是芳香族碳环或杂环; Ar 2由以下任一个环等表示。
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公开(公告)号：US20160137633A1
公开(公告)日：2016-05-19
申请号：US15010404
申请日：2016-01-29
Applicant: Ajinomoto Co., Inc.
Inventor： Tadakiyo NAKAGAWA , Kayo Matsumoto , Sen Takeshita , Tomomi Yoshida , Munetaka Tokumasu , Hiroki Inoue , Kaori Kobayashi
IPC: C07D413/12 , C07D409/12 , C07D207/16 , C07D403/12 , C07D405/12 , C07D307/80
CPC classification number: C07D413/12 , A61K31/343 , A61K31/397 , A61K31/401 , A61K31/4025 , A61K31/404 , A61K31/427 , A61K31/536 , C07D207/16 , C07D307/79 , C07D307/80 , C07D403/12 , C07D405/12 , C07D409/12
Abstract: Provided is a compound represented by the following general formula (I), or a pharmaceutically acceptable salt thereof. This novel compound has a glycogen-synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe. In the formula, Ar is an aromatic carbocyclic ring or a heterocyclic ring; and Ar2 is represented by any one of the following rings and the like.
Abstract translation: 提供由以下通式（I）表示的化合物或其药学上可接受的盐。 这种新型化合物具有糖原合成酶的活化能力，但能够将受体PPAR活性降低到很低的程度。 在该式中，Ar是芳香族碳环或杂环; Ar 2由以下任一个环等表示。
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公开(公告)号：US20140309135A1
公开(公告)日：2014-10-16
申请号：US14261953
申请日：2014-04-25
Applicant: AJINOMOTO CO., INC.
Inventor： Naoyuki FUKUCHI , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
IPC: C07D487/04 , G01N33/50 , G01N33/573 , G01N33/68 , C12Q1/48
CPC classification number: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
Abstract translation: 筛选具有降血糖作用的化合物的方法（以下称为“降血糖化合物”），含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说，可以列举一种能够将降血糖化合物 绑定到＆bgr 三聚GTP结合蛋白的亚单位，包含降血糖化合物的糖尿病治疗剂，其特征在于能够结合到该组合物上。 三聚GTP结合蛋白的亚基作为活性成分等
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公开(公告)号：US08772281B2
公开(公告)日：2014-07-08
申请号：US13709798
申请日：2012-12-10
Applicant: Ajinomoto Co., Inc.
Inventor： Naoyuki Fukuchi , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
CPC classification number: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
Abstract translation: 筛选具有降血糖作用的化合物的方法（以下称为“降血糖化合物”），含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说，可以列举一种能够将降血糖化合物 绑定到＆bgr 三聚GTP结合蛋白的亚单位，包含降血糖化合物的糖尿病治疗剂，其特征在于能够结合到该组合物上。 三聚GTP结合蛋白的亚基作为活性成分等
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