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公开(公告)号：US10457911B2
公开(公告)日：2019-10-29
申请号：US15275586
申请日：2016-09-26
Applicant: AJINOMOTO CO., INC.
Inventor： Yoko Kuriyama , Satoru Okamoto , Manabu Kitazawa , Nao Sugimoto , Takuya Matsumoto
Abstract: Culture media which contain a water-soluble polymer, such as polyvinyl alcohol and the like, and albumin, and the like, are useful for the proliferation of stem cells, and show good culture results, particularly with iPS cells, and maintain the stability of the medium properties, as well as using a reduced amount of albumin.
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公开(公告)号：US09890359B2
公开(公告)日：2018-02-13
申请号：US14497926
申请日：2014-09-26
Applicant: AJINOMOTO CO., INC.
Inventor： Yoko Kuriyama , Nao Sugimoto , Manabu Kitazawa , Satoru Okamoto , Sho Senda , Ikue Harata , Satoru Ohashi
IPC: C12N5/0775 , C12N5/074 , C08G63/91 , C08G65/48
CPC classification number: C12N5/0663 , C08G63/912 , C08G65/48 , C12N5/0696 , C12N2500/34 , C12N2501/115
Abstract: A medium which comprises a fibroblast growth factor (FGF), and a sulfated compound or a pharmaceutically acceptable salt thereof at a concentration which promotes the growth of a stem cell in the presence of FGF, is useful for culturing stem cells.
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公开(公告)号：US10745669B2
公开(公告)日：2020-08-18
申请号：US14813374
申请日：2015-07-30
Applicant: AJINOMOTO CO., INC.
Inventor： Sho Senda , Tomomi Yoshida , Satoru Okamoto , Yoko Kuriyama , Manabu Kitazawa , Ikue Harata , Nao Sugimoto
IPC: C12N5/00 , C12N5/02 , C12N5/074 , C12N5/0735
Abstract: Cultivating a pluripotent stem cell in a medium comprising at least one member selected from the group consisting of ethanolamine, an ethanolamine analog, and a pharmaceutically acceptable salt thereof, and which is substantially free of β-mercaptoethanol or contains β-mercaptoethanol at a concentration of not more than 9 μM, and the like, is effective for the proliferation of a pluripotent stem cell while maintaining an undifferentiated state.
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公开(公告)号：US20130130277A1
公开(公告)日：2013-05-23
申请号：US13709798
申请日：2012-12-10
Applicant: AJINOMOTO CO., INC.
Inventor： Naoyuki FUKUCHI , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
IPC: C07D487/04 , G01N33/68
CPC classification number: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
Abstract translation: 筛选具有降血糖作用的化合物的方法（以下称为“降血糖化合物”），含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说，可以列举一种能够将降血糖化合物 与三聚GTP结合蛋白的β亚基结合，包括降血糖化合物的糖尿病治疗剂，其特征在于能够结合三聚体GTP结合蛋白的β亚基作为活性成分等。
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公开(公告)号：US10662411B2
公开(公告)日：2020-05-26
申请号：US16242463
申请日：2019-01-08
Applicant: AJINOMOTO CO., INC.
Inventor： Sho Senda , Tomomi Yoshida , Satoru Okamoto , Yoko Kuriyama , Manabu Kitazawa , Ikue Harata , Nao Sugimoto
IPC: C12N5/00 , C12N5/02 , C12N5/074 , C12N5/0735
Abstract: Cultivating a pluripotent stem cell in a medium comprising at least one member selected from the group consisting of ethanolamine, an ethanolamine analog, and a pharmaceutically acceptable salt thereof, and which is substantially free of β-mercaptoethanol or contains β-mercaptoethanol at a concentration of not more than 9 μM, and the like, is effective for the proliferation of a pluripotent stem cell while maintaining an undifferentiated state.
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Patent Agency Ranking
公开(公告)号：US20180105798A1
公开(公告)日：2018-04-19
申请号：US15847246
申请日：2017-12-19
Applicant: AJINOMOTO CO., INC.
Inventor： Yoko KURIYAMA , Nao Sugimoto , Manabu Kitazawa , Satoru Okamoto , Sho Senda , Ikue Harata , Satoru Ohashi
IPC: C12N5/0775 , C08G65/48 , C08G63/91 , C12N5/074
Abstract: A medium which comprises a fibroblast growth factor (FGF), and a sulfated compound or a pharmaceutically acceptable salt thereof at a concentration which promotes the growth of a stem cell in the presence of FGF, is useful for culturing stem cells.
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公开(公告)号：US20140309135A1
公开(公告)日：2014-10-16
申请号：US14261953
申请日：2014-04-25
Applicant: AJINOMOTO CO., INC.
Inventor： Naoyuki FUKUCHI , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
IPC: C07D487/04 , G01N33/50 , G01N33/573 , G01N33/68 , C12Q1/48
CPC classification number: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
Abstract translation: 筛选具有降血糖作用的化合物的方法（以下称为“降血糖化合物”），含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说，可以列举一种能够将降血糖化合物 绑定到＆bgr 三聚GTP结合蛋白的亚单位，包含降血糖化合物的糖尿病治疗剂，其特征在于能够结合到该组合物上。 三聚GTP结合蛋白的亚基作为活性成分等
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公开(公告)号：US20200208120A1
公开(公告)日：2020-07-02
申请号：US16727449
申请日：2019-12-26
Applicant: AJINOMOTO CO., INC.
Inventor： Kazuya YONEYAMA , Kotoe Koseki , Mizuho Yokoyama , Satoru Okamoto
IPC: C12N5/074 , C12N5/0735
Abstract: A medium which contains a riboflavin derivative is useful for proliferating and culturing pluripotent stem cells such as iPS cells and ES cells, and is free from degradation due to storage as complete medium.
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公开(公告)号：US10689622B2
公开(公告)日：2020-06-23
申请号：US15847246
申请日：2017-12-19
Applicant: AJINOMOTO CO., INC.
Inventor： Yoko Kuriyama , Nao Sugimoto , Manabu Kitazawa , Satoru Okamoto , Sho Senda , Ikue Harata , Satoru Ohashi
IPC: C12N5/0775 , C12N5/074 , C08G65/48 , C08G63/91
Abstract: A medium which comprises a fibroblast growth factor (FGF), and a sulfated compound or a pharmaceutically acceptable salt thereof at a concentration which promotes the growth of a stem cell in the presence of FGF, is useful for culturing stem cells.
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公开(公告)号：US08772281B2
公开(公告)日：2014-07-08
申请号：US13709798
申请日：2012-12-10
Applicant: Ajinomoto Co., Inc.
Inventor： Naoyuki Fukuchi , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
CPC classification number: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
Abstract translation: 筛选具有降血糖作用的化合物的方法（以下称为“降血糖化合物”），含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说，可以列举一种能够将降血糖化合物 绑定到＆bgr 三聚GTP结合蛋白的亚单位，包含降血糖化合物的糖尿病治疗剂，其特征在于能够结合到该组合物上。 三聚GTP结合蛋白的亚基作为活性成分等
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