公开(公告)号：US20190016763A1

公开(公告)日：2019-01-17

申请号：US16144562

申请日：2018-09-27

Applicant: AJINOMOTO CO., INC.

Inventor： Manabu Kitazawa ,  Nao Sugimoto ,  Riho Kodama ,  Takeshi Nagahiko ,  Yoshihiro Ito ,  Kentaro Nakase ,  Yoshinori Takashima ,  Ayako Mine ,  Yoko Kuwabara ,  Uno Tagami ,  Masayuki Sugiki

IPC: C07K14/435 ,  C12N15/62 ,  C12N5/00 ,  C07K2/00 ,  C12M3/04 ,  C12N5/071 ,  C12N5/074

Abstract: A technique for efficiently culturing cells such as stem cells is provided. Cells such as stem cells are cultured using a cell culture vessel coated with a fibroin-like protein into which a cell adhesion sequence containing RGD (Arg-Gly-Asp) is inserted.

公开(公告)号：US09102630B2

公开(公告)日：2015-08-11

申请号：US14206540

申请日：2014-03-12

Applicant: AJINOMOTO CO., INC.

Inventor： Noriyasu Kataoka ,  Riho Kodama ,  Akinori Tatara

IPC: A61K31/517 ,  C07D239/72 ,  C07D239/96

CPC classification number: C07D239/96

Abstract: Provided is a crystal of a salt of the compound represented by formula (I), which is excellent in its solubility in water. In particular, also provided is a crystal of hydrochloride, hydrobromate, sulfate, nitrate, p-toluenesulfonate or methanesulfonate of the compound represented by formula (I).

Abstract translation: 提供由式（I）表示的化合物的盐的结晶，其在水中的溶解性优异。 特别地，还提供了由式（I）表示的化合物的盐酸盐，氢溴酸盐，硫酸盐，硝酸盐，对甲苯磺酸盐或甲磺酸盐的结晶。

公开(公告)号：US09181202B2

公开(公告)日：2015-11-10

申请号：US13632474

申请日：2012-10-01

Applicant: AJINOMOTO CO., INC.

Inventor： Noriyasu Kataoka ,  Riho Kodama ,  Akinori Tatara

IPC: A61K31/517 ,  C07D239/72 ,  C07D239/96

CPC classification number: C07D239/96

Abstract: Provided is a crystal of a salt of the compound represented by formula (I), which is excellent in its solubility in water. In particular, also provided is a crystal of hydrochloride, hydrobromate, sulfate, nitrate, p-toluenesulfonate or methanesulfonate of the compound represented by formula (I).