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公开(公告)号:US09450174B2
公开(公告)日:2016-09-20
申请号:US14458632
申请日:2014-08-13
申请人: AJINOMOTO CO., INC.
发明人: Satoru Ohashi , Sei Uemura , Manabu Kitazawa , Toshihide Kamata , Yoshinori Wada
摘要: Poly(α-amino acid) which contain: (A) a glutamic acid γ-ester unit represented by formula (I): and (B) one or more kinds of units selected from a glutamic acid γ-ester unit represented by formula (II), an alanine unit, a phenylalanine unit and an Nε-benzyloxycarbonyllysine unit, represented by formula (III), and a glutamic acid γ-ester unit represented by formula (IV) can be dissolved in various solvents and are useful for preparing piezoelectric elements which exhibit superior piezoelectricity.
摘要翻译: 含有(A)式(I)所示的谷氨酸γ-酯单元的聚(α-氨基酸)和(B)选自由式(I)表示的谷氨酸γ-酯单元的一种或多种单元 II),由式(III)表示的丙氨酸单元,苯丙氨酸单元和Nε-苄氧羰基赖氨酸单元和由式(IV)表示的谷氨酸γ-酯单元可以溶解在各种溶剂中,并且可用于制备压电 表现出优异的压电性的元件。
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公开(公告)号:US09192624B2
公开(公告)日:2015-11-24
申请号:US13911776
申请日:2013-06-06
申请人: Ajinomoto Co., Inc.
IPC分类号: A61K31/785 , D01F6/68 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , A61L27/00 , D01D5/00
CPC分类号: A61K31/785 , A61L27/00 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , D01D5/0038 , D01F6/68 , C08L77/00
摘要: The present invention aims to provide a medical material which is safe for the live body, has high biocompatibility and is useful for promotion of cell differentiation. The present invention produces a medical material for promoting cell differentiation, which contains polyamino acid as a main component, wherein the polyamino acid contains at least one kind of amino acid residue selected from the group consisting of an alanine residue, a valine residue, a leucine residue, an isoleucine residue, a phenylalanine residue, a glycine residue, a glutamine residue, an aspartic acid residue optionally containing a protecting group in the side chain, a tyrosine residue optionally containing a protecting group in the side chain, a tryptophan residue optionally containing a protecting group in the side chain, a lysine residue optionally containing a protecting group in the side chain, and a glutamic acid residue optionally containing a protecting group in the side chain.
摘要翻译: 本发明的目的在于提供对活体安全的医疗用材料,具有高的生物相容性,对促进细胞分化是有用的。 本发明生产含有聚氨基酸作为主要成分的促进细胞分化的医药材料,其中聚氨基酸含有选自丙氨酸残基,缬氨酸残基,亮氨酸中的至少一种氨基酸残基 残基,异亮氨酸残基,苯丙氨酸残基,甘氨酸残基,谷氨酰胺残基,任选含有侧链保护基的天冬氨酸残基,任选地含有侧链保护基的酪氨酸残基,任选含有 侧链中的保护基,任选地含有侧链保护基的赖氨酸残基,以及任选地在侧链中含有保护基的谷氨酸残基。
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公开(公告)号:US20140368083A1
公开(公告)日:2014-12-18
申请号:US14458632
申请日:2014-08-13
申请人: AJINOMOTO CO., INC.
发明人: Satoru OHASHI , Sei Uemura , Manabu Kitazawa , Toshihide Kamata , Yoshinori Wada
IPC分类号: H01L41/193 , H01L41/29 , C08G69/10
摘要: Poly(α-amino acid) which contain: (A) a glutamic acid γ-ester unit represented by formula (I): and (B) one or more kinds of units selected from a glutamic acid γ-ester unit represented by formula (II), an alanine unit, a phenylalanine unit and an Nε-benzyloxycarbonyllysine unit, represented by formula (III), and a glutamic acid γ-ester unit represented by formula (IV) can be dissolved in various solvents and are useful for preparing piezoelectric elements which exhibit superior piezoelectricity.
摘要翻译: 含有(A)式(I)所示的谷氨酸γ-酯单元的聚(α-氨基酸)和(B)选自由式(I)表示的谷氨酸γ-酯单元的一种或多种单元 II),由式(III)表示的丙氨酸单元,苯丙氨酸单元和N,N'-苄氧羰基赖氨酸单元和由式(IV)表示的谷氨酸γ-酯单元可以溶解在各种溶剂中,并且可用于制备 表现出优异的压电性的压电元件。
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公开(公告)号:US10662411B2
公开(公告)日:2020-05-26
申请号:US16242463
申请日:2019-01-08
申请人: AJINOMOTO CO., INC.
发明人: Sho Senda , Tomomi Yoshida , Satoru Okamoto , Yoko Kuriyama , Manabu Kitazawa , Ikue Harata , Nao Sugimoto
IPC分类号: C12N5/00 , C12N5/02 , C12N5/074 , C12N5/0735
摘要: Cultivating a pluripotent stem cell in a medium comprising at least one member selected from the group consisting of ethanolamine, an ethanolamine analog, and a pharmaceutically acceptable salt thereof, and which is substantially free of β-mercaptoethanol or contains β-mercaptoethanol at a concentration of not more than 9 μM, and the like, is effective for the proliferation of a pluripotent stem cell while maintaining an undifferentiated state.
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公开(公告)号:US20180105798A1
公开(公告)日:2018-04-19
申请号:US15847246
申请日:2017-12-19
申请人: AJINOMOTO CO., INC.
发明人: Yoko KURIYAMA , Nao Sugimoto , Manabu Kitazawa , Satoru Okamoto , Sho Senda , Ikue Harata , Satoru Ohashi
IPC分类号: C12N5/0775 , C08G65/48 , C08G63/91 , C12N5/074
摘要: A medium which comprises a fibroblast growth factor (FGF), and a sulfated compound or a pharmaceutically acceptable salt thereof at a concentration which promotes the growth of a stem cell in the presence of FGF, is useful for culturing stem cells.
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公开(公告)号:US09786450B2
公开(公告)日:2017-10-10
申请号:US14706156
申请日:2015-05-07
申请人: AJINOMOTO CO., INC.
发明人: Yoshinori Wada , Hiroyasu Koto , Yuichi Watanabe , Sei Uemura , Manabu Kitazawa , Satoru Ohashi , Toshihide Kamata
IPC分类号: H01L41/04 , H01H13/14 , H03K17/96 , H01L41/113 , H01L41/18 , H01L41/193
CPC分类号: H01H13/14 , H01H2209/024 , H01H2209/074 , H01H2221/002 , H01L41/1132 , H01L41/183 , H01L41/193 , H03K17/9643
摘要: A membrane switch in which a first conductive part is formed on a first substrate, a second conductive part is formed on a second substrate, and the substrates are layered via a spacer such that the conductive parts face each other with a space therebetween, and an organic material showing piezoelectricity is filled, or disposed in the space such that an air gap is present, are useful for obtaining an output signal corresponding to an applied pressure.
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公开(公告)号:US20130266620A1
公开(公告)日:2013-10-10
申请号:US13911776
申请日:2013-06-06
申请人: Ajinomoto Co., Inc.
IPC分类号: A61K31/785 , A61L27/00
CPC分类号: A61K31/785 , A61L27/00 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , D01D5/0038 , D01F6/68 , C08L77/00
摘要: The present invention aims to provide a medical material which is safe for the live body, has high biocompatibility and is useful for promotion of cell differentiation. The present invention produces a medical material for promoting cell differentiation, which contains polyamino acid as a main component, wherein the polyamino acid contains at least one kind of amino acid residue selected from the group consisting of an alanine residue, a valine residue, a leucine residue, an isoleucine residue, a phenylalanine residue, a glycine residue, a glutamine residue, an aspartic acid residue optionally containing a protecting group in the side chain, a tyrosine residue optionally containing a protecting group in the side chain, a tryptophan residue optionally containing a protecting group in the side chain, a lysine residue optionally containing a protecting group in the side chain, and a glutamic acid residue optionally containing a protecting group in the side chain.
摘要翻译: 本发明的目的在于提供对活体安全的医疗用材料,具有高的生物相容性,对促进细胞分化是有用的。 本发明生产含有聚氨基酸作为主要成分的促进细胞分化的医药材料,其中聚氨基酸含有选自丙氨酸残基,缬氨酸残基,亮氨酸中的至少一种氨基酸残基 残基,异亮氨酸残基,苯丙氨酸残基,甘氨酸残基,谷氨酰胺残基,任选含有侧链保护基的天冬氨酸残基,任选地含有侧链保护基的酪氨酸残基,任选含有 侧链中的保护基,任选地含有侧链保护基的赖氨酸残基,以及任选地在侧链中含有保护基的谷氨酸残基。
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公开(公告)号:US11859205B2
公开(公告)日:2024-01-02
申请号:US16898844
申请日:2020-06-11
申请人: AJINOMOTO CO., INC.
发明人: Yoko Kuriyama , Sho Senda , Yumi Ando , Tomomi Yoshida , Haruna Sato , Daisuke Ejima , Takayoshi Fujii , Masayo Date , Manabu Kitazawa
IPC分类号: C12N5/074 , C12N5/0735 , C12N5/071 , C12N5/00
CPC分类号: C12N5/0602 , C12N5/0018 , C12N5/0696 , C12N5/0606 , C12N2500/36 , C12N2501/998
摘要: Culture media, which contain albumin carrying a reduced amount of fatty acid, are useful for culturing stem cells.
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公开(公告)号:US10457911B2
公开(公告)日:2019-10-29
申请号:US15275586
申请日:2016-09-26
申请人: AJINOMOTO CO., INC.
摘要: Culture media which contain a water-soluble polymer, such as polyvinyl alcohol and the like, and albumin, and the like, are useful for the proliferation of stem cells, and show good culture results, particularly with iPS cells, and maintain the stability of the medium properties, as well as using a reduced amount of albumin.
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公开(公告)号:US09890359B2
公开(公告)日:2018-02-13
申请号:US14497926
申请日:2014-09-26
申请人: AJINOMOTO CO., INC.
发明人: Yoko Kuriyama , Nao Sugimoto , Manabu Kitazawa , Satoru Okamoto , Sho Senda , Ikue Harata , Satoru Ohashi
IPC分类号: C12N5/0775 , C12N5/074 , C08G63/91 , C08G65/48
CPC分类号: C12N5/0663 , C08G63/912 , C08G65/48 , C12N5/0696 , C12N2500/34 , C12N2501/115
摘要: A medium which comprises a fibroblast growth factor (FGF), and a sulfated compound or a pharmaceutically acceptable salt thereof at a concentration which promotes the growth of a stem cell in the presence of FGF, is useful for culturing stem cells.
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