公开(公告)号：US20190016763A1

公开(公告)日：2019-01-17

申请号：US16144562

申请日：2018-09-27

申请人： AJINOMOTO CO., INC.

发明人： Manabu Kitazawa ,  Nao Sugimoto ,  Riho Kodama ,  Takeshi Nagahiko ,  Yoshihiro Ito ,  Kentaro Nakase ,  Yoshinori Takashima ,  Ayako Mine ,  Yoko Kuwabara ,  Uno Tagami ,  Masayuki Sugiki

IPC分类号： C07K14/435 ,  C12N15/62 ,  C12N5/00 ,  C07K2/00 ,  C12M3/04 ,  C12N5/071 ,  C12N5/074

摘要： A technique for efficiently culturing cells such as stem cells is provided. Cells such as stem cells are cultured using a cell culture vessel coated with a fibroin-like protein into which a cell adhesion sequence containing RGD (Arg-Gly-Asp) is inserted.

公开(公告)号：US20200239920A1

公开(公告)日：2020-07-30

申请号：US16774075

申请日：2020-01-28

申请人： AJINOMOTO CO., INC.

发明人： Hiromi Noguchi ,  Yo Nishiyama ,  Yoshihiro Ito

IPC分类号： C12P13/14 ,  C12N15/74 ,  C07K14/265

摘要： A method for producing an L-amino acid such as L-glutamic acid is provided. An L-amino acid is produced by culturing in a medium a bacterium having an L-amino acid-producing ability, which has been modified so that the activity of a c1795 protein is reduced or the activity of a protein of which the expression is repressed by a c1795 protein is increased, and collecting the L-amino acid from the medium or cells of the bacterium.

公开(公告)号：US10787691B2

公开(公告)日：2020-09-29

申请号：US16774075

申请日：2020-01-28

申请人： AJINOMOTO CO., INC.

发明人： Hiromi Noguchi ,  Yo Nishiyama ,  Yoshihiro Ito

IPC分类号： C12N15/09 ,  C07K1/00 ,  C12P7/02 ,  C12P13/14 ,  C07K14/265 ,  C12N15/74

摘要： A method for producing an L-amino acid such as L-glutamic acid is provided. An L-amino acid is produced by culturing in a medium a bacterium having an L-amino acid-producing ability, which has been modified so that the activity of a c1795 protein is reduced or the activity of a protein of which the expression is repressed by a c1795 protein is increased, and collecting the L-amino acid from the medium or cells of the bacterium.