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公开(公告)号：US09062335B2
公开(公告)日：2015-06-23
申请号：US14483644
申请日：2014-09-11
申请人： AJINOMOTO CO., INC.
发明人： Ryo Takeshita , Shinichi Sugimoto
摘要： A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
摘要翻译： 一种通过发酵生产碱性物质的方法，包括在包含在发酵罐中的液体培养基中培养具有生产碱性物质的能力的微生物，以在培养基中产生和积累碱性物质，其中硫酸盐和/或氯离子的量 用作碱性物质的抗衡离子的方法是通过在培养过程的至少一部分时间内将培养基中的总氨浓度调节到特定浓度范围内来减少。
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公开(公告)号：US09334511B2
公开(公告)日：2016-05-10
申请号：US14483588
申请日：2014-09-11
申请人： AJINOMOTO CO., INC.
发明人： Ryo Takeshita , Shinichi Sugimoto
摘要： A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
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公开(公告)号：US20150259716A1
公开(公告)日：2015-09-17
申请号：US14483588
申请日：2014-09-11
申请人： AJINOMOTO CO., INC.
发明人： Ryo Takeshita , Shinichi Sugimoto
摘要： A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
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公开(公告)号：US20150010962A1
公开(公告)日：2015-01-08
申请号：US14483611
申请日：2014-09-11
申请人： AJINOMOTO CO., INC.
发明人： Ryo Takeshita , Shinichi Sugimoto
摘要： A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
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公开(公告)号：US09334512B2
公开(公告)日：2016-05-10
申请号：US14483611
申请日：2014-09-11
申请人： AJINOMOTO CO., INC.
发明人： Ryo Takeshita , Shinichi Sugimoto
摘要： A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
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公开(公告)号：US20150010963A1
公开(公告)日：2015-01-08
申请号：US14483644
申请日：2014-09-11
申请人： AJINOMOTO CO., INC.
发明人： Ryo Takeshita , Shinichi Sugimoto
摘要： A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
摘要翻译： 一种通过发酵生产碱性物质的方法，包括在包含在发酵罐中的液体培养基中培养具有生产碱性物质的能力的微生物，以在培养基中产生和积累碱性物质，其中硫酸盐和/或氯离子的量 用作碱性物质的抗衡离子的方法是通过在培养过程的至少一部分时间内将培养基中的总氨浓度调节到特定浓度范围内来减少。
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7.发明申请公开(公告)号：US20130171700A1
公开(公告)日：2013-07-04
申请号：US13772959
申请日：2013-02-21
申请人： Ajinomoto Co., Inc.
发明人： Yoshiya Gunji , Hisashi Yasueda , Shinichi Sugimoto , Nobuharu Tsujimoto , Megumi Shimaoka , Yuri Miyata , Manami Oba
IPC分类号： C12P13/08
CPC分类号： C12P13/08 , C12N9/1217 , C12N9/88 , C12P13/04 , C12R1/01
摘要： An L-amino acid is produced by culturing a Methylophilus bacterium which can grow by using methanol as the main carbon source and has L-amino acid-producing ability, for example, a Methylophilus bacterium in which dihydrodipicolinate synthase activity and aspartokinase activity are enhanced by transformation of cells with a DNA coding for dihydrodipicolinate synthase that is desensitized to feedback inhibition by L-lysine and a DNA coding for aspartokinase that is desensitized to feedback inhibition by L-lysine, or a Methylophilus bacterium which is casamino acid auxotrophic, in a medium containing methanol as a main carbon source, to produce and accumulate an L-amino acid in culture, and collecting the L-amino acid from the culture.
摘要翻译： 通过培养可以通过使用甲醇作为主要碳源生长并且具有L-氨基酸生产能力的甲型幽门螺杆菌细菌产生L-氨基酸，例如其中二氢吡啶二酸合成酶活性和天冬氨酸激酶活性被增强的甲基幽门螺杆菌 将编码二脱氧叶酸二磷酸合酶的DNA转化为L-赖氨酸的反馈抑制的脱氧赖氨酸的编码天冬氨酸激酶的DNA或L-赖氨酸反馈抑制的天冬氨酸的DNA或作为酪蛋白氨基酸营养缺陷型的细鳞状芽孢杆菌属细菌的DNA在培养基 含有甲醇作为主要碳源，在培养中产生和积累L-氨基酸，并从培养物中收集L-氨基酸。
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