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公开(公告)号：US20150337254A1
公开(公告)日：2015-11-26
申请号：US14815328
申请日：2015-07-31
Applicant: Ajinomoto Co., Inc.
Inventor： Ryo Takeshita
CPC classification number: C12M41/34 , C12M41/26 , C12M41/32 , C12M41/48 , C12N1/20 , C12P13/08 , C12P13/10 , C12P13/24
Abstract: An method for controlling ammonia concentration of a culture medium contained in a culture tank, by using an ammonia-controlling apparatus comprising at least an ammonia feeder that supplies ammonia to the culture tank, an ammonia sensor that responds to non-ionized ammonia in the culture medium contained in the culture tank, and a control part connected to the ammonia feeder and the ammonia sensor, and which method comprises the following steps performed by the control part: calculating non-ionized ammonia concentration of the culture medium contained in the culture tank from the signal from the ammonia sensor by using a calibration curve representing relation between non-ionized ammonia concentration of the culture medium contained in the culture tank and a signal from the ammonia sensor; and directing the ammonia feeder to supply ammonia to the culture tank when the calculated non-ionized ammonia concentration is lower than a predetermined concentration.
Abstract translation: 通过使用至少包含向培养槽供给氨的氨供料器的氨控制装置，对培养槽中所含的培养基的氨浓度进行控制的方法，对培养液中的非电离氨进行响应的氨传感器 培养槽中含有的培养基和与氨供给器和氨传感器连接的控制部，该方法包括由控制部执行以下步骤：计算培养罐中含有的培养基的非离子化氨浓度 通过使用表示培养槽中所含培养基的非离子化氨浓度与来自氨传感器的信号之间的关系的校正曲线来从氨传感器得到的信号; 并且当所计算的非电离氨浓度低于预定浓度时，引导氨供料器向培养槽供应氨。
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公开(公告)号：US20150259716A1
公开(公告)日：2015-09-17
申请号：US14483588
申请日：2014-09-11
Applicant: AJINOMOTO CO., INC.
Inventor： Ryo Takeshita , Shinichi Sugimoto
Abstract: A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
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公开(公告)号：US20150010962A1
公开(公告)日：2015-01-08
申请号：US14483611
申请日：2014-09-11
Applicant: AJINOMOTO CO., INC.
Inventor： Ryo Takeshita , Shinichi Sugimoto
Abstract: A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
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公开(公告)号：US11198894B2
公开(公告)日：2021-12-14
申请号：US16268082
申请日：2019-02-05
Applicant: AJINOMOTO CO., INC.
Inventor： Kazuteru Yamada , Ye Zhang , Kenji Abe , Naoki Iwanaga , Ryo Takeshita , Yuri Uehara , Chika Hikichi , Yasuhiro Oota
IPC: C12P13/20 , C12P13/08 , C12P13/04 , C12N15/09 , A23K50/80 , A23K10/18 , A01K61/10 , A01K61/59 , C12N1/20 , C12P13/14
Abstract: A method for producing an L-amino acid such as L-lysine is provided. An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability, which has been modified so that the activity of a carotenoid biosynthesis enzyme is increased, in a medium, and collecting the L-amino acid from the medium.
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公开(公告)号：US09334511B2
公开(公告)日：2016-05-10
申请号：US14483588
申请日：2014-09-11
Applicant: AJINOMOTO CO., INC.
Inventor： Ryo Takeshita , Shinichi Sugimoto
Abstract: A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
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Patent Agency Ranking
公开(公告)号：US20190161780A1
公开(公告)日：2019-05-30
申请号：US16268082
申请日：2019-02-05
Applicant: AJINOMOTO CO., INC.
Inventor： Kazuteru Yamada , Ye Zhang , Kenji Abe , Naoki Iwanaga , Ryo Takeshita , Yuri Uehara , Chika Hikichi , Yasuhiro Oota
IPC: C12P13/08 , C12P13/04 , C12P13/20 , C12P13/14 , C12N1/20 , A23K50/80 , A23K10/18 , A01K61/10 , A01K61/59
Abstract: A method for producing an L-amino acid such as L-lysine is provided. An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability, which has been modified so that the activity of a carotenoid biosynthesis enzyme is increased, in a medium, and collecting the L-amino acid from the medium.
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公开(公告)号：US09708577B2
公开(公告)日：2017-07-18
申请号：US14815328
申请日：2015-07-31
Applicant: Ajinomoto Co., Inc.
Inventor： Ryo Takeshita
CPC classification number: C12M41/34 , C12M41/26 , C12M41/32 , C12M41/48 , C12N1/20 , C12P13/08 , C12P13/10 , C12P13/24
Abstract: An method for controlling ammonia concentration of a culture medium contained in a culture tank, by using an ammonia-controlling apparatus comprising at least an ammonia feeder that supplies ammonia to the culture tank, an ammonia sensor that responds to non-ionized ammonia in the culture medium contained in the culture tank, and a control part connected to the ammonia feeder and the ammonia sensor, and which method comprises the following steps performed by the control part: calculating non-ionized ammonia concentration of the culture medium contained in the culture tank from the signal from the ammonia sensor by using a calibration curve representing relation between non-ionized ammonia concentration of the culture medium contained in the culture tank and a signal from the ammonia sensor; and directing the ammonia feeder to supply ammonia to the culture tank when the calculated non-ionized ammonia concentration is lower than a predetermined concentration.
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公开(公告)号：US09062335B2
公开(公告)日：2015-06-23
申请号：US14483644
申请日：2014-09-11
Applicant: AJINOMOTO CO., INC.
Inventor： Ryo Takeshita , Shinichi Sugimoto
Abstract: A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
Abstract translation: 一种通过发酵生产碱性物质的方法，包括在包含在发酵罐中的液体培养基中培养具有生产碱性物质的能力的微生物，以在培养基中产生和积累碱性物质，其中硫酸盐和/或氯离子的量 用作碱性物质的抗衡离子的方法是通过在培养过程的至少一部分时间内将培养基中的总氨浓度调节到特定浓度范围内来减少。
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公开(公告)号：US20140080185A1
公开(公告)日：2014-03-20
申请号：US14085171
申请日：2013-11-20
Applicant: AJINOMOTO CO., INC.
Inventor： Ryo Takeshita , Naoki Kadotani , Kenji Abe
IPC: C12P13/08
CPC classification number: C12P13/08 , C12N9/1205 , C12N9/2402 , C12P13/22 , C12Y302/0101
Abstract: A method is described for producing a target substance utilizing a microorganism by culturing the microorganism in a medium to produce and accumulate the target substance in the medium, and then collecting the target substance from culture. The microorganism is imparted with isomaltase activity, or modified to increase isomaltase activity.
Abstract translation: 描述了一种用于通过在培养基中培养微生物来生产和利用微生物的目标物质生产和累积目标物质的方法，然后从培养物中收集目标物质。 赋予微生物异麦芽糖酶活性，或修饰以增加异麦芽糖酶活性。
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公开(公告)号：US09334512B2
公开(公告)日：2016-05-10
申请号：US14483611
申请日：2014-09-11
Applicant: AJINOMOTO CO., INC.
Inventor： Ryo Takeshita , Shinichi Sugimoto
Abstract: A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
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