公开(公告)号：US10689622B2

公开(公告)日：2020-06-23

申请号：US15847246

申请日：2017-12-19

Applicant: AJINOMOTO CO., INC.

Inventor： Yoko Kuriyama ,  Nao Sugimoto ,  Manabu Kitazawa ,  Satoru Okamoto ,  Sho Senda ,  Ikue Harata ,  Satoru Ohashi

IPC: C12N5/0775 ,  C12N5/074 ,  C08G65/48 ,  C08G63/91

Abstract: A medium which comprises a fibroblast growth factor (FGF), and a sulfated compound or a pharmaceutically acceptable salt thereof at a concentration which promotes the growth of a stem cell in the presence of FGF, is useful for culturing stem cells.

公开(公告)号：US20150311012A1

公开(公告)日：2015-10-29

申请号：US14706156

申请日：2015-05-07

Applicant: AJINOMOTO CO., INC.

Inventor： Yoshinori WADA ,  Hiroyasu Koto ,  Yuichi Watanabe ,  Sei Uemura ,  Manabu Kitazawa ,  Satoru Ohashi ,  Toshihide Kamata

IPC: H01H13/14

CPC classification number: H01H13/14 ,  H01H2209/024 ,  H01H2209/074 ,  H01H2221/002 ,  H01L41/1132 ,  H01L41/183 ,  H01L41/193 ,  H03K17/9643

Abstract: A membrane switch in which a first conductive part is formed on a first substrate, a second conductive part is formed on a second substrate, and the substrates are layered via a spacer such that the conductive parts face each other with a space therebetween, and an organic material showing piezoelectricity is filled, or disposed in the space such that an air gap is present, are useful for obtaining an output signal corresponding to an applied pressure.

Abstract translation: 一种膜开关，其中第一导电部分形成在第一基板上，第二导电部分形成在第二基板上，并且基板经由间隔件层叠，使得导电部件彼此面对并具有间隔，并且 显示压电性的有机材料填充或设置在空间中以使得存在气隙，可用于获得对应于所施加的压力的输出信号。

公开(公告)号：US09890359B2

公开(公告)日：2018-02-13

申请号：US14497926

申请日：2014-09-26

Applicant: AJINOMOTO CO., INC.

Inventor： Yoko Kuriyama ,  Nao Sugimoto ,  Manabu Kitazawa ,  Satoru Okamoto ,  Sho Senda ,  Ikue Harata ,  Satoru Ohashi

IPC: C12N5/0775 ,  C12N5/074 ,  C08G63/91 ,  C08G65/48

CPC classification number: C12N5/0663 ,  C08G63/912 ,  C08G65/48 ,  C12N5/0696 ,  C12N2500/34 ,  C12N2501/115

Abstract: A medium which comprises a fibroblast growth factor (FGF), and a sulfated compound or a pharmaceutically acceptable salt thereof at a concentration which promotes the growth of a stem cell in the presence of FGF, is useful for culturing stem cells.

公开(公告)号：US09450174B2

公开(公告)日：2016-09-20

申请号：US14458632

申请日：2014-08-13

Applicant: AJINOMOTO CO., INC.

Inventor： Satoru Ohashi ,  Sei Uemura ,  Manabu Kitazawa ,  Toshihide Kamata ,  Yoshinori Wada

IPC: H01L41/08 ,  H01L41/193 ,  H01L41/45 ,  C08G69/10 ,  C08L77/04 ,  H01L41/29

CPC classification number: H01L41/193 ,  C08G69/10 ,  C08L77/04 ,  H01L41/29 ,  H01L41/45 ,  Y10T29/42

Abstract: Poly(α-amino acid) which contain: (A) a glutamic acid γ-ester unit represented by formula (I): and (B) one or more kinds of units selected from a glutamic acid γ-ester unit represented by formula (II), an alanine unit, a phenylalanine unit and an Nε-benzyloxycarbonyllysine unit, represented by formula (III), and a glutamic acid γ-ester unit represented by formula (IV) can be dissolved in various solvents and are useful for preparing piezoelectric elements which exhibit superior piezoelectricity.

Abstract translation: 含有（A）式（I）所示的谷氨酸γ-酯单元的聚（α-氨基酸）和（B）选自由式（I）表示的谷氨酸γ-酯单元的一种或多种单元 II），由式（III）表示的丙氨酸单元，苯丙氨酸单元和Nε-苄氧羰基赖氨酸单元和由式（IV）表示的谷氨酸γ-酯单元可以溶解在各种溶剂中，并且可用于制备压电 表现出优异的压电性的元件。

公开(公告)号：US09192624B2

公开(公告)日：2015-11-24

申请号：US13911776

申请日：2013-06-06

Applicant: Ajinomoto Co., Inc.

Inventor： Manabu Kitazawa ,  Satoru Ohashi ,  Yoko Masuzawa ,  Kousaku Ohkawa ,  Yasuhiko Tabata

IPC: A61K31/785 ,  D01F6/68 ,  A61L27/18 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  A61L27/00 ,  D01D5/00

CPC classification number: A61K31/785 ,  A61L27/00 ,  A61L27/18 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  D01D5/0038 ,  D01F6/68 ,  C08L77/00

Abstract: The present invention aims to provide a medical material which is safe for the live body, has high biocompatibility and is useful for promotion of cell differentiation. The present invention produces a medical material for promoting cell differentiation, which contains polyamino acid as a main component, wherein the polyamino acid contains at least one kind of amino acid residue selected from the group consisting of an alanine residue, a valine residue, a leucine residue, an isoleucine residue, a phenylalanine residue, a glycine residue, a glutamine residue, an aspartic acid residue optionally containing a protecting group in the side chain, a tyrosine residue optionally containing a protecting group in the side chain, a tryptophan residue optionally containing a protecting group in the side chain, a lysine residue optionally containing a protecting group in the side chain, and a glutamic acid residue optionally containing a protecting group in the side chain.

Abstract translation: 本发明的目的在于提供对活体安全的医疗用材料，具有高的生物相容性，对促进细胞分化是有用的。 本发明生产含有聚氨基酸作为主要成分的促进细胞分化的医药材料，其中聚氨基酸含有选自丙氨酸残基，缬氨酸残基，亮氨酸中的至少一种氨基酸残基 残基，异亮氨酸残基，苯丙氨酸残基，甘氨酸残基，谷氨酰胺残基，任选含有侧链保护基的天冬氨酸残基，任选地含有侧链保护基的酪氨酸残基，任选含有 侧链中的保护基，任选地含有侧链保护基的赖氨酸残基，以及任选地在侧链中含有保护基的谷氨酸残基。

公开(公告)号：US09464167B2

公开(公告)日：2016-10-11

申请号：US14076363

申请日：2013-11-11

Applicant: AJINOMOTO CO., INC.

Inventor： Satoru Ohashi ,  Sei Uemura ,  Manabu Kitazawa ,  Toshihide Kamata

IPC: G11C11/22 ,  H01L41/08 ,  H01L41/193 ,  C08G69/10 ,  C08G63/685 ,  H01L51/05 ,  H01L51/00 ,  B82Y10/00 ,  H01L29/78

CPC classification number: C08G63/685 ,  B82Y10/00 ,  G11C11/22 ,  G11C11/221 ,  H01L29/78391 ,  H01L51/0002 ,  H01L51/0003 ,  H01L51/0512 ,  H01L51/052 ,  H01L51/0591

Abstract: Ferroelectric memory elements which contain a poly α-amino acid which is a copolymer containing a glutamic acid-γ-ester unit represented by the formula (I), defined herein, and a glutamic acid-γ-ester unit represented by the formula (II), defined herein, in a molar ratio of units of formula (I) to units of formula (II) of 10/90-90/10 are useful as recording elements such as RFID and the like.

Abstract translation: 含有本文定义的由式（I）表示的谷氨酸-γ-酯单元和由式（II）表示的谷氨酸-γ-酯单元的共聚物的聚α-氨基酸的铁电记忆元件 ）定义为以式（I）单元与式（II）单元的摩尔比为10 / 90-90 / 10的摩尔比可用作诸如RFID等的记录元件。

公开(公告)号：US09295624B2

公开(公告)日：2016-03-29

申请号：US14287899

申请日：2014-05-27

Applicant: AJINOMOTO CO. INC.

Inventor： Yusuke Amino ,  Yoshinobu Takino ,  Satoru Ohashi ,  Fumie Okura ,  Megumi Kaneko

IPC: A61K31/4045 ,  C07D209/32 ,  A61K8/49 ,  A61K8/42 ,  A61Q19/02 ,  C07C235/34 ,  C07D209/14 ,  C07D209/20 ,  C07D405/12

CPC classification number: A61K8/492 ,  A61K8/42 ,  A61K8/49 ,  A61K31/4045 ,  A61Q19/02 ,  C07C235/34 ,  C07D209/14 ,  C07D209/20 ,  C07D209/32 ,  C07D405/12

Abstract: Compound represented by formula (I): wherein the symbols are as defined in the description, and salts thereof, are useful as skin whitening agents.

Abstract translation: 由式（I）表示的化合物：其中符号如说明书中所定义，及其盐可用作皮肤增白剂。

公开(公告)号：US20180105798A1

公开(公告)日：2018-04-19

申请号：US15847246

申请日：2017-12-19

Applicant: AJINOMOTO CO., INC.

Inventor： Yoko KURIYAMA ,  Nao Sugimoto ,  Manabu Kitazawa ,  Satoru Okamoto ,  Sho Senda ,  Ikue Harata ,  Satoru Ohashi

IPC: C12N5/0775 ,  C08G65/48 ,  C08G63/91 ,  C12N5/074

Abstract: A medium which comprises a fibroblast growth factor (FGF), and a sulfated compound or a pharmaceutically acceptable salt thereof at a concentration which promotes the growth of a stem cell in the presence of FGF, is useful for culturing stem cells.

公开(公告)号：US09786450B2

公开(公告)日：2017-10-10

申请号：US14706156

申请日：2015-05-07

Applicant: AJINOMOTO CO., INC.

Inventor： Yoshinori Wada ,  Hiroyasu Koto ,  Yuichi Watanabe ,  Sei Uemura ,  Manabu Kitazawa ,  Satoru Ohashi ,  Toshihide Kamata

IPC: H01L41/04 ,  H01H13/14 ,  H03K17/96 ,  H01L41/113 ,  H01L41/18 ,  H01L41/193

CPC classification number: H01H13/14 ,  H01H2209/024 ,  H01H2209/074 ,  H01H2221/002 ,  H01L41/1132 ,  H01L41/183 ,  H01L41/193 ,  H03K17/9643

Abstract: A membrane switch in which a first conductive part is formed on a first substrate, a second conductive part is formed on a second substrate, and the substrates are layered via a spacer such that the conductive parts face each other with a space therebetween, and an organic material showing piezoelectricity is filled, or disposed in the space such that an air gap is present, are useful for obtaining an output signal corresponding to an applied pressure.

公开(公告)号：US20130266620A1

公开(公告)日：2013-10-10

申请号：US13911776

申请日：2013-06-06

Applicant: Ajinomoto Co., Inc.

Inventor： Manabu Kitazawa ,  Satoru Ohashi ,  Yoko Masuzawa ,  Kousaku Ohkawa ,  Yasuhiko Tabata

IPC: A61K31/785 ,  A61L27/00

CPC classification number: A61K31/785 ,  A61L27/00 ,  A61L27/18 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  D01D5/0038 ,  D01F6/68 ,  C08L77/00

Abstract: The present invention aims to provide a medical material which is safe for the live body, has high biocompatibility and is useful for promotion of cell differentiation. The present invention produces a medical material for promoting cell differentiation, which contains polyamino acid as a main component, wherein the polyamino acid contains at least one kind of amino acid residue selected from the group consisting of an alanine residue, a valine residue, a leucine residue, an isoleucine residue, a phenylalanine residue, a glycine residue, a glutamine residue, an aspartic acid residue optionally containing a protecting group in the side chain, a tyrosine residue optionally containing a protecting group in the side chain, a tryptophan residue optionally containing a protecting group in the side chain, a lysine residue optionally containing a protecting group in the side chain, and a glutamic acid residue optionally containing a protecting group in the side chain.

Abstract translation: 本发明的目的在于提供对活体安全的医疗用材料，具有高的生物相容性，对促进细胞分化是有用的。 本发明生产含有聚氨基酸作为主要成分的促进细胞分化的医药材料，其中聚氨基酸含有选自丙氨酸残基，缬氨酸残基，亮氨酸中的至少一种氨基酸残基 残基，异亮氨酸残基，苯丙氨酸残基，甘氨酸残基，谷氨酰胺残基，任选含有侧链保护基的天冬氨酸残基，任选地含有侧链保护基的酪氨酸残基，任选含有 侧链中的保护基，任选地含有侧链保护基的赖氨酸残基，以及任选地在侧链中含有保护基的谷氨酸残基。