-
公开(公告)号：US10981984B2
公开(公告)日：2021-04-20
申请号：US16217567
申请日：2018-12-12
发明人： Adisa Kuburas , Bianca Mason , Levi P. Sowers , Andrew F. Russo , Maria-Cristina Loomis , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendricks , Ethan W. Ojala , Pei Fan , Jeffrey T. L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： A61K49/00 , A61K49/16 , A61K39/395 , A61K39/00 , G01N33/53 , C07K16/00 , C12P21/08 , C07K16/26 , A61P25/06 , G01N33/50 , A61K45/06 , G01N33/74 , C07K16/42 , C07K14/575
摘要： This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.
-
公开(公告)号：US10913783B2
公开(公告)日：2021-02-09
申请号：US15487642
申请日：2017-04-14
发明人： Maria-Cristina Loomis , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T. L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： C07K16/26 , A61K39/395 , C12N15/09 , C12N15/12 , C12N15/63 , C07K14/705 , C07K16/28 , A61K38/17 , A61K38/22 , C07K14/47 , C07K14/72 , C07K16/18 , C12N5/07 , C07K16/42 , G01N33/68 , C07K14/575 , A61P25/06 , A61K38/00 , A61K48/00 , A61K39/00
摘要： The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.
-
公开(公告)号：US10202435B2
公开(公告)日：2019-02-12
申请号：US15487607
申请日：2017-04-14
发明人： Maria-Cristina Loomis , Leon Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T. L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： A61K49/00 , A61K39/395 , A61K39/00 , A61K49/16 , C07K16/00 , G01N33/53 , C12P21/08 , C07K14/705 , A61K38/17 , A61K38/22 , C07K14/47 , C07K14/72 , C07K16/18 , C07K16/28 , C12N5/07 , C07K16/26 , C07K16/42 , G01N33/68 , A61K38/00 , A61K48/00
摘要： The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.
-
公开(公告)号：US20200181229A1
公开(公告)日：2020-06-11
申请号：US16787250
申请日：2020-02-11
发明人： Maria-Cristina Loomis , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T.L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： C07K14/705 , C12N15/09 , C12N15/63 , A61K39/395 , C07K16/28 , A61K38/17 , A61K38/22 , C07K14/47 , C07K14/72 , C07K16/18 , C12N5/07 , C07K16/26 , C07K16/42 , G01N33/68
摘要： The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.
-
公开(公告)号：US20170298127A1
公开(公告)日：2017-10-19
申请号：US15487607
申请日：2017-04-14
发明人： Maria-Cristina LOOMIS , Leon Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T.L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
CPC分类号： C07K14/70503 , A61K38/00 , A61K38/17 , A61K38/22 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/72 , C07K16/18 , C07K16/26 , C07K16/28 , C07K16/2869 , C07K16/4241 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N5/06 , G01N33/6854 , G01N2333/575 , Y02A50/383
摘要： The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.
-
6.发明申请CULTURE METHOD FOR OBTAINING A CLONAL POPULATION OF ANTIGEN-SPECIFIC B CELLS 审中-公开用于获得抗原特异性B细胞克隆人群的培养方法公开(公告)号：US20130316353A1
公开(公告)日：2013-11-28
申请号：US13861518
申请日：2013-04-12
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C07K16/00 , C07K16/241 , C07K16/248 , C12N5/0635 , C12N2502/11
摘要： The present invention relates to methods of isolating antigen-specific cells and producing antibodies therefrom.
摘要翻译： 本发明涉及分离抗原特异性细胞并由其产生抗体的方法。
-
公开(公告)号：US20190233498A1
公开(公告)日：2019-08-01
申请号：US16272406
申请日：2019-02-11
发明人： Maria-Cristina Loomis , Leon Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T.L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： C07K14/705 , A61K38/22 , C07K16/18 , C12N5/07 , G01N33/68 , C07K16/42 , C07K16/26 , C07K16/28 , C07K14/72 , C07K14/47 , A61K38/17 , C12N15/09 , C12N15/63 , A61K39/395
CPC分类号： C07K14/70503 , A61K38/00 , A61K38/17 , A61K38/22 , A61K39/3955 , A61K48/00 , A61K2039/505 , A61P25/06 , C07K14/47 , C07K14/575 , C07K14/72 , C07K16/18 , C07K16/26 , C07K16/28 , C07K16/2869 , C07K16/4241 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N5/06 , C12N15/09 , C12N15/63 , G01N33/6854 , G01N2333/575 , Y02A50/382 , Y02A50/383
摘要： The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.
-
8.发明申请PROTOCOL FOR IDENTIFYING AND ISOLATING ANTIGEN-SPECIFIC B CELLS AND PRODUCING ANTIBODIES TO DESIRED ANTIGENS 审中-公开用于鉴定和分离抗原特异性B细胞并将抗体产生于所需抗原的协议公开(公告)号：US20160033504A1
公开(公告)日：2016-02-04
申请号：US14776945
申请日：2014-03-18
发明人： Daniel S. Allison , Benjamin H. Dutzar , Leon F. Garcia-Martinez , Katie Anderson , Ethan W. Ojala , John A. Latham , Jens Billgren , Anne Elisabeth Carvalho Jensen
IPC分类号： G01N33/569
CPC分类号： G01N33/56972 , C07K16/18 , C07K16/22 , C07K16/40 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/5052
摘要： Methods of identifying antigen-specific antibody-secreting and antibody-forming cells, such as antigen-specific B cells, and methods for cloning the antigen-specific antibody sequences of the antibody produced by these cells are provided. In particular, the methods include enriching B cells for antigen-specific B cells, culturing the antigen-specific B cells to generate clonal B cell populations, detecting clonal B cells that produce a single antigen-specific antibody, optionally screening the clonal B cell populations for functional activity, staining and sorting the cells to isolate the antigen-specific B cells, sequencing the nucleic acids encoding the antigen-specific antibody sequences, expressing the sequences to produce an antibody, isolating the antibody and screening the antibody for antigen recognition. The methods provide improved enrichment and selection of antigen-specific antibody-secreting and antibody-forming cells, which enhances recovery of antigen-specific antibodies.
摘要翻译： 提供了鉴定抗原特异性抗体分泌型和抗体形成细胞如抗原特异性B细胞的方法，以及用于克隆由这些细胞产生的抗体的抗原特异性抗体序列的方法。 特别地，所述方法包括富集B细胞用于抗原特异性B细胞，培养抗原特异性B细胞以产生克隆B细胞群体，检测产生单一抗原特异性抗体的克隆B细胞，任选筛选克隆B细胞群 用于功能活性，染色和分选细胞以分离抗原特异性B细胞，测序编码抗原特异性抗体序列的核酸，表达序列以产生抗体，分离抗体并筛选抗体以进行抗原识别。 该方法提供改进的抗原特异性抗体分泌和抗体形成细胞的富集和选择，其增强抗原特异性抗体的回收。
-
公开(公告)号：US11254741B2
公开(公告)日：2022-02-22
申请号：US16242792
申请日：2019-01-08
发明人： Maria-Cristina Loomis , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T. L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： C07K16/26 , A61K39/395 , C07K14/575 , A61P25/06 , G01N33/50 , A61K45/06 , G01N33/74 , A61K39/00 , C07K16/42 , A61K49/00
摘要： The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.
-
公开(公告)号：US10899834B2
公开(公告)日：2021-01-26
申请号：US15130848
申请日：2016-04-15
发明人： Maria-Cristina Loomis , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T. L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： C07K16/26 , A61K39/395 , A61P25/06 , G01N33/50 , A61K45/06 , G01N33/74 , C07K16/42 , A61K49/00 , C07K14/575 , A61K39/00
摘要： The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.021 秒)
