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公开(公告)号：US20190233498A1
公开(公告)日：2019-08-01
申请号：US16272406
申请日：2019-02-11
发明人： Maria-Cristina Loomis , Leon Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T.L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： C07K14/705 , A61K38/22 , C07K16/18 , C12N5/07 , G01N33/68 , C07K16/42 , C07K16/26 , C07K16/28 , C07K14/72 , C07K14/47 , A61K38/17 , C12N15/09 , C12N15/63 , A61K39/395
CPC分类号： C07K14/70503 , A61K38/00 , A61K38/17 , A61K38/22 , A61K39/3955 , A61K48/00 , A61K2039/505 , A61P25/06 , C07K14/47 , C07K14/575 , C07K14/72 , C07K16/18 , C07K16/26 , C07K16/28 , C07K16/2869 , C07K16/4241 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N5/06 , C12N15/09 , C12N15/63 , G01N33/6854 , G01N2333/575 , Y02A50/382 , Y02A50/383
摘要： The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.
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公开(公告)号：US10981984B2
公开(公告)日：2021-04-20
申请号：US16217567
申请日：2018-12-12
发明人： Adisa Kuburas , Bianca Mason , Levi P. Sowers , Andrew F. Russo , Maria-Cristina Loomis , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendricks , Ethan W. Ojala , Pei Fan , Jeffrey T. L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： A61K49/00 , A61K49/16 , A61K39/395 , A61K39/00 , G01N33/53 , C07K16/00 , C12P21/08 , C07K16/26 , A61P25/06 , G01N33/50 , A61K45/06 , G01N33/74 , C07K16/42 , C07K14/575
摘要： This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.
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公开(公告)号：US10913783B2
公开(公告)日：2021-02-09
申请号：US15487642
申请日：2017-04-14
发明人： Maria-Cristina Loomis , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T. L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： C07K16/26 , A61K39/395 , C12N15/09 , C12N15/12 , C12N15/63 , C07K14/705 , C07K16/28 , A61K38/17 , A61K38/22 , C07K14/47 , C07K14/72 , C07K16/18 , C12N5/07 , C07K16/42 , G01N33/68 , C07K14/575 , A61P25/06 , A61K38/00 , A61K48/00 , A61K39/00
摘要： The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.
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公开(公告)号：US10202435B2
公开(公告)日：2019-02-12
申请号：US15487607
申请日：2017-04-14
发明人： Maria-Cristina Loomis , Leon Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T. L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： A61K49/00 , A61K39/395 , A61K39/00 , A61K49/16 , C07K16/00 , G01N33/53 , C12P21/08 , C07K14/705 , A61K38/17 , A61K38/22 , C07K14/47 , C07K14/72 , C07K16/18 , C07K16/28 , C12N5/07 , C07K16/26 , C07K16/42 , G01N33/68 , A61K38/00 , A61K48/00
摘要： The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.
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公开(公告)号：US20200181229A1
公开(公告)日：2020-06-11
申请号：US16787250
申请日：2020-02-11
发明人： Maria-Cristina Loomis , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T.L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： C07K14/705 , C12N15/09 , C12N15/63 , A61K39/395 , C07K16/28 , A61K38/17 , A61K38/22 , C07K14/47 , C07K14/72 , C07K16/18 , C12N5/07 , C07K16/26 , C07K16/42 , G01N33/68
摘要： The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.
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公开(公告)号：US20170298127A1
公开(公告)日：2017-10-19
申请号：US15487607
申请日：2017-04-14
发明人： Maria-Cristina LOOMIS , Leon Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T.L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
CPC分类号： C07K14/70503 , A61K38/00 , A61K38/17 , A61K38/22 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/72 , C07K16/18 , C07K16/26 , C07K16/28 , C07K16/2869 , C07K16/4241 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N5/06 , G01N33/6854 , G01N2333/575 , Y02A50/383
摘要： The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.
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公开(公告)号：US11254741B2
公开(公告)日：2022-02-22
申请号：US16242792
申请日：2019-01-08
发明人： Maria-Cristina Loomis , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T. L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： C07K16/26 , A61K39/395 , C07K14/575 , A61P25/06 , G01N33/50 , A61K45/06 , G01N33/74 , A61K39/00 , C07K16/42 , A61K49/00
摘要： The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.
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公开(公告)号：US10899834B2
公开(公告)日：2021-01-26
申请号：US15130848
申请日：2016-04-15
发明人： Maria-Cristina Loomis , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T. L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： C07K16/26 , A61K39/395 , A61P25/06 , G01N33/50 , A61K45/06 , G01N33/74 , C07K16/42 , A61K49/00 , C07K14/575 , A61K39/00
摘要： The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.
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公开(公告)号：US10179813B2
公开(公告)日：2019-01-15
申请号：US15130658
申请日：2016-04-15
发明人： Adisa Kuburas , Ethan W. Ojala , Pei Fan , Jeffrey T. L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren , Bianca Mason , Levi P. Sowers , Andrew F. Russo , Maria-Cristina Loomis , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix
IPC分类号： A61K49/00 , C07K16/00 , A61K39/395 , A61K39/00 , A61K49/16 , G01N33/53 , C12P21/08 , C07K16/26 , A61K45/06 , G01N33/74 , G01N33/50
摘要： This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.
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公开(公告)号：US20160362488A1
公开(公告)日：2016-12-15
申请号：US15130263
申请日：2016-04-15
发明人： Maria-Cristina LOOMIS , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Lee Hendricks , Ethan W. Ojala , Pei Fan , Jeffrey T.L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren
IPC分类号： C07K16/26 , A61K39/395 , A61K45/06 , C07K16/42
CPC分类号： C07K16/26 , A61K39/3955 , A61K39/39566 , A61K45/06 , A61K49/0004 , A61K49/0008 , A61K2039/505 , A61P25/06 , C07K14/57536 , C07K16/4241 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/76 , C07K2317/92 , G01N33/5088 , G01N33/74 , G01N2333/5757 , Y02A50/383
摘要： The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.
摘要翻译： 本发明涉及对PACAP具有结合特异性的拮抗性抗体及其抗原结合片段。 这些抗体抑制，阻断或中和与PACAP相关的至少一种生物学作用，例如血管舒张。 在示例性实施方案中，这些抗体及其抗原结合片段可以包含本文所述的特异性VH，VL和CDR多肽。 在一些实施方案中，这些抗体及其抗原结合片段与人PACAP上的特异性表位结合和/或竞争结合特异性表位。 本发明进一步涉及将这些拮抗性抗PACAP抗体及其结合片段用于诊断，评估和治疗与PACAP相关的疾病和病症以及PACAP相关活性如血管舒张，肥大细胞的拮抗作用 脱颗粒和/或神经元激活是治疗有益的，例如头痛和偏头痛适应症。
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