-
公开(公告)号：US09663460B2
公开(公告)日：2017-05-30
申请号：US14482718
申请日：2014-09-10
申请人： ALLERGAN, INC.
发明人： Haiqing Yuan , Richard L. Beard , Michael E. Garst , John E. Donello , Xiaoxia Liu , Veena Viswanath
IPC分类号： C07C323/09 , C07C317/22 , A61K31/18 , A61K31/10 , A61P31/00 , A61P27/02 , C07C311/21 , C07C317/36 , C07D405/12 , C07D307/82 , C07C323/49 , C07D233/64 , C07D417/12 , C07D213/52 , C07D333/34 , C07F9/30 , C07F9/32 , C07F9/40 , C07F9/53 , C07F9/59 , C07F9/6533 , C07D307/64 , C07D413/12 , C07D277/40
CPC分类号： C07C311/21 , C07C317/34 , C07C317/36 , C07C317/42 , C07C317/44 , C07C317/50 , C07C321/30 , C07C323/49 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/67 , C07C2601/08 , C07D207/09 , C07D207/46 , C07D213/32 , C07D213/52 , C07D233/64 , C07D277/40 , C07D295/13 , C07D295/185 , C07D295/24 , C07D307/64 , C07D307/82 , C07D333/34 , C07D405/12 , C07D413/12 , C07D417/12 , C07F9/304 , C07F9/3229 , C07F9/4021 , C07F9/5325 , C07F9/59 , C07F9/6533
摘要： The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
-
公开(公告)号：US09603834B2
公开(公告)日：2017-03-28
申请号：US14847934
申请日：2015-09-08
申请人： Allergan, Inc.
发明人： Haiqing Yuan , Richard L. Beard , Michael E. Garst , Xiaoxia Liu , John E. Donello , Veena Viswanath
IPC分类号： A61K31/381 , A61K31/422 , A61K31/404 , A61K31/423 , A61K31/429 , A61K31/4155 , A61K31/4436 , A61K31/4709 , A61K31/428 , A61K31/506 , A61K31/4725 , A61K31/4196 , C07C311/21 , C07C311/44 , C07D231/18 , C07D307/82 , C07D333/34 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07D513/04 , A61K31/343 , A61K31/37 , A61K31/4245 , A61K31/427 , A61K31/497 , A61K31/498 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/55 , A61K31/635
CPC分类号： A61K31/381 , A61K31/343 , A61K31/37 , A61K31/404 , A61K31/4155 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/429 , A61K31/4436 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/55 , A61K31/635 , C07C311/21 , C07C311/44 , C07D231/18 , C07D307/82 , C07D333/34 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07D513/04
摘要： The present invention relates to novel bis-sulfonamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
-
公开(公告)号：US08822530B2
公开(公告)日：2014-09-02
申请号：US13794494
申请日：2013-03-11
申请人： Allergan, Inc.
发明人： Haiqing Yuan , Richard L. Beard , Xiaoxia Liu , John E. Donello , Veena Viswanath , Michael E. Garst
IPC分类号： C07D307/82 , A61K31/343 , A61P31/00
CPC分类号： C07C311/21 , C07C317/34 , C07C317/36 , C07C317/42 , C07C317/44 , C07C317/50 , C07C321/30 , C07C323/49 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/67 , C07C2601/08 , C07D207/09 , C07D207/46 , C07D213/32 , C07D213/52 , C07D233/64 , C07D277/40 , C07D295/13 , C07D295/185 , C07D295/24 , C07D307/64 , C07D307/82 , C07D333/34 , C07D405/12 , C07D413/12 , C07D417/12 , C07F9/304 , C07F9/3229 , C07F9/4021 , C07F9/5325 , C07F9/59 , C07F9/6533
摘要： The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
-
4.发明申请6-SUBSTITUTED INDOLE-3-CARBOXYLIC ACID AMIDE COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY 审中-公开具有丝氨酸1-磷酸（S1P）受体拮抗剂生物活性的6-取代的吲哚-3-羧酸酰胺化合物公开(公告)号：US20130338158A1
公开(公告)日：2013-12-19
申请号：US13946564
申请日：2013-07-19
申请人： Allergan, Inc.
发明人： Richard L. Beard , John E. Donello , Tien T. Duong , Xiaoxia Liu , Haiging Yuan
IPC分类号： C07D209/42 , C07D401/12 , C07D401/06 , C07D413/06 , C07D401/14 , C07D403/06 , C07D413/04 , C07D413/14 , C07D413/12 , C07D417/12 , C07D405/14 , C07D417/14 , C07D405/12 , C07D403/04
CPC分类号： C07D209/42 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity: and wherein the variables Y, R4, n, o, A, A1, A2, X, Z, R1, R3, R2, p, q and r are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing
摘要翻译： 本发明提供式I表示的化合物，其中每一种化合物可具有鞘氨醇-1-磷酸受体激动剂和/或拮抗剂生物活性，其中变量Y，R4，n，o，A，A1，A2，X， Z，R1，R3，R2，p，q和r如说明书中所定义。 这些化合物可用于治疗选自青光眼，干眼症，血管生成，心血管疾病和疾病以及伤口愈合的疾病或病症
-
公开(公告)号：US08877804B2
公开(公告)日：2014-11-04
申请号：US13872845
申请日：2013-04-29
申请人： Allergan, Inc.
发明人： Haiqing Yuan , Richard L. Beard , Michael E. Garst , John E. Donello , Xiaoxia Liu , Veena Viswanath
IPC分类号： A61K31/343 , C07D307/82 , A61P27/02 , A61P31/00 , C07C323/49 , C07D413/12 , C07D307/64 , C07D233/64 , C07C317/34 , C07D417/12 , C07D405/12
CPC分类号： C07C311/21 , C07C317/34 , C07C317/36 , C07C317/42 , C07C317/44 , C07C317/50 , C07C321/30 , C07C323/49 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/67 , C07C2601/08 , C07D207/09 , C07D207/46 , C07D213/32 , C07D213/52 , C07D233/64 , C07D277/40 , C07D295/13 , C07D295/185 , C07D295/24 , C07D307/64 , C07D307/82 , C07D333/34 , C07D405/12 , C07D413/12 , C07D417/12 , C07F9/304 , C07F9/3229 , C07F9/4021 , C07F9/5325 , C07F9/59 , C07F9/6533
摘要： The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
摘要翻译： 本发明涉及新的硫衍生物，其制备方法，含有它们的药物组合物及其作为药物作为趋化因子受体调节剂的用途。
-
6.发明申请PYRIDINYL AND PYRIMIDINYL SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS 有权吡啶并吡啶酰胺衍生物作为化学受体调节剂公开(公告)号：US20140275132A1
公开(公告)日：2014-09-18
申请号：US14206491
申请日：2014-03-12
申请人： Allergan, Inc.
发明人： Richard L. Beard , John E. Donello , Veena Viswanath , Michael E. Garst , Haiqing Yuan , Xiaoxia Liu
IPC分类号： C07D409/12 , C07D213/76 , C07D405/12
CPC分类号： C07D409/12 , C07D213/75 , C07D213/76 , C07D405/12 , C07D413/10
摘要： The present invention relates to novel pyridine or pyrimidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors. The invention relates specifically to the use of these compounds and their pharmaceutical compositions to treat disorders associated with chemokine receptor modulation.
摘要翻译： 本发明涉及新颖的吡啶或嘧啶衍生物，其制备方法，含有它们的药物组合物及其作为药物作为趋化因子受体调节剂的用途。 本发明具体涉及这些化合物及其药物组合物用于治疗与趋化因子受体调节相关的病症的用途。
-
7.发明授权Benzofuran-2-sulfonamides pyridine derivatives as chemokine receptor modulators 有权苯并呋喃-2-磺酰胺吡啶衍生物作为趋化因子受体调节剂公开(公告)号：US08815915B2
公开(公告)日：2014-08-26
申请号：US13782174
申请日：2013-03-01
申请人： Allergan, Inc.
发明人： Haiqing Yuan , Richard L. Beard , Xiaoxia Liu , John E. Donello , Veena Viswanath , Michael E. Garst
IPC分类号： A61K31/44 , A01N43/40 , C07D405/14 , C07D307/82 , C07D405/12
CPC分类号： C07D307/78 , A61P29/00 , C07D307/82 , C07D405/12 , C07D405/14
摘要： The present invention relates to novel benzofuran-2-sulfonamide pyridine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
摘要翻译： 本发明涉及新型苯并呋喃-2-磺酰胺吡啶衍生物，其制备方法，含有它们的药物组合物及其作为药物作为趋化因子受体调节剂的用途。
-
公开(公告)号：US20140051682A1
公开(公告)日：2014-02-20
申请号：US14034945
申请日：2013-09-24
申请人： ALLERGAN, INC.
发明人： Haiqing Yuan , Richard L. Beard , Michael E. Garst , Xiaoxia Liu , John E. Donello , Veena Viswanath
IPC分类号： C07D333/34 , C07D409/12 , C07D417/12 , C07D413/12 , C07D405/12 , C07D513/04
CPC分类号： A61K31/381 , A61K31/343 , A61K31/37 , A61K31/404 , A61K31/4155 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/429 , A61K31/4436 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/55 , A61K31/635 , C07C311/21 , C07C311/44 , C07D231/18 , C07D307/82 , C07D333/34 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07D513/04
摘要： The present invention relates to novel bis-sulfonamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
-
公开(公告)号：US11046644B2
公开(公告)日：2021-06-29
申请号：US16410885
申请日：2019-05-13
申请人： ALLERGAN, INC.
发明人： Haiqing Yuan , Richard L. Beard , Xiaoxia Liu , John E. Donello , Veena Viswanath , Michael E. Garst
IPC分类号： C07C311/21 , C07D307/82 , C07C323/49 , C07C317/34 , C07D307/64 , C07C311/44 , A61K31/18 , A61K31/10 , A61P27/02 , C07F9/59 , C07C317/44 , C07C323/52 , C07C323/56 , C07C323/60 , C07D295/13 , C07D295/185 , C07D295/24 , C07F9/30 , C07F9/32 , C07F9/40 , C07F9/53 , C07F9/6533 , C07D233/64 , C07D405/12 , C07D413/12 , C07D417/12 , C07C317/36 , C07D213/52 , C07D333/34 , C07D277/40 , C07C317/42 , C07C317/50 , C07C323/67 , C07D213/32 , C07C321/30 , C07D207/09 , C07D207/46
摘要： The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
-
10.发明授权公开(公告)号：US08729066B2
公开(公告)日：2014-05-20
申请号：US14034945
申请日：2013-09-24
申请人： Allergan, Inc.
发明人： Haiqing Yuan , Richard L. Beard , Michael E. Garst , Xiaoxia Liu , John E. Donello , Veena Viswanath
IPC分类号： A61K31/55
CPC分类号： A61K31/381 , A61K31/343 , A61K31/37 , A61K31/404 , A61K31/4155 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/429 , A61K31/4436 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/55 , A61K31/635 , C07C311/21 , C07C311/44 , C07D231/18 , C07D307/82 , C07D333/34 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07D513/04
摘要： The present invention relates to novel bis-sulfonamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
摘要翻译： 本发明涉及新的双磺酰胺衍生物，其制备方法，含有它们的药物组合物及其作为药物作为趋化因子受体调节剂的用途。
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.027 秒)
