专利检索 ap:("ALPHA-O PEPTIDES AG") AND inv:"Sara Maria PAULILLO" 第 1 页

1.

发明公开
SELF-ASSEMBLING PROTEIN NANOPARTICLES WITH BUILT-IN SIX-HELIX BUNDLE PROTEINS 审中-公开

公开(公告)号：US20230340031A1

公开(公告)日：2023-10-26

申请号：US18189601

申请日：2023-03-24

申请人： ALPHA-O PEPTIDES AG

发明人： Caroline KULANGARA , Sara Maria PAULILLO , Matteo PIAZZA , Senthil Kumar RAMAN , Peter BURKHARD

IPC分类号： C07K14/005 , A61K39/21 , A61K39/145

CPC分类号： C07K14/005 , A61K39/145 , A61K39/21 , A61K2039/55555

摘要： The present invention relates to self-assembling protein nanoparticles with built-in six-helix bundle proteins. Proteins or peptides comprising a loop region are stabilized by attaching them to six-helix bundle (SHB) proteins and integrating them into self-assembling protein nanoparticles (SAPNs).

2.

发明申请
FLAGELLIN-CONTAINING PROTEIN NANOPARTICLES AS A VACCINE PLATFORM 审中-公开
标题翻译：含有FLAGELLIN的蛋白纳米颗粒作为疫苗平台

公开(公告)号：US20160324958A1

公开(公告)日：2016-11-10

申请号：US15110449

申请日：2015-01-09

申请人： ALPHA-O PEPTIDES AG

发明人： Peter BURKHARD , Senthil Kumar RAMAN , Sara Maria PAULILLO , Matteo PIAZZA , Caroline KULANGARA , Christian MITTELHOLZER

IPC分类号： A61K39/39 , C07K14/195

CPC分类号： A61K39/39 , A61K39/0013 , A61K39/015 , A61K2039/55555 , A61K2039/6068 , A61K2039/64 , C07K14/195

摘要： The present invention relates to self-assembling protein nanoparticles constructed from suitable oligomerization domains and further incorporating the TLR5 binding protein flagellin as an adjuvant molecule. Furthermore, the invention relates to the use of such nanoparticles for vaccination.

摘要翻译： 本发明涉及由合适的低聚结构域构建的进一步掺入TLR5结合蛋白鞭毛蛋白作为佐剂分子的自组装蛋白质纳米颗粒。此外，本发明涉及这种纳米颗粒用于疫苗接种的用途。

3.

发明公开
SELF-ASSEMBLING PROTEIN NANOPARTICLES ENCAPSULATING IMMUNOSTIMULATORY NUCLEID ACIDS 审中-公开

公开(公告)号：US20240075120A1

公开(公告)日：2024-03-07

申请号：US18297207

申请日：2023-04-07

申请人： ALPHA-O PEPTIDES AG

发明人： Caroline KULANGARA , Sara Maria PAULILLO , Matteo PIAZZA , Senthil Kumar RAMAN , Peter BURKHARD

IPC分类号： A61K39/00 , A61K39/015 , A61K39/112 , A61K39/12 , A61K39/245 , A61K39/39 , A61P31/22 , A61P33/06 , C12N7/00

CPC分类号： A61K39/0013 , A61K39/015 , A61K39/0275 , A61K39/12 , A61K39/245 , A61K39/39 , A61P31/22 , A61P33/06 , C12N7/00 , A61K2039/55555 , A61K2039/55561 , C07K14/005 , C12N2710/16634

摘要： The present invention relates to self-assembling protein nanoparticles encapsulating immunostimulatory nucleid acids. Furthermore, the invention relates to the use of such nanoparticles for vaccination.

4.

发明申请
SELF-ASSEMBLING PROTEIN NANOPARTICLES ENCAPSULATING IMMUNOSTIMULATORY NUCLEID ACIDS 审中-公开

公开(公告)号：US20200061172A1

公开(公告)日：2020-02-27

申请号：US16488197

申请日：2018-02-22

申请人： ALPHA-O PEPTIDES AG

发明人： Caroline KULANGARA , Sara Maria PAULILLO , Matteo PIAZZA , Senthil Kumar RAMAN , Peter BURKHARD

IPC分类号： A61K39/00 , A61K39/112 , A61K39/39 , A61K39/015 , A61P33/06 , A61K39/245 , C12N7/00 , A61P31/22

摘要： The present invention relates to self-assembling protein nanoparticles encapsulating immunostimulatory nucleid acids. Furthermore, the invention relates to the use of such nanoparticles for vaccination.

5.

发明申请
SELF-ASSEMBLING PROTEIN NANOPARTICLES WITH BUILT-IN SIX-HELIX BUNDLE PROTEINS 审中-公开

公开(公告)号：US20200017554A1

公开(公告)日：2020-01-16

申请号：US16495590

申请日：2018-03-22

申请人： ALPHA-O PEPTIDES AG

发明人： Caroline KULANGARA , Sara Maria PAULILLO , Matteo PIAZZA , Senthil Kumar RAMAN , Peter BURKHARD

IPC分类号： C07K14/005 , A61K39/145 , A61K39/21

摘要： The present invention relates to self-assembling protein nanoparticles with built-in six-helix bundle proteins. Proteins or peptides comprising a loop region are stabilized by attaching them to six-helix bundle (SHB) proteins and integrating them into self-assembling protein nanoparticles (SAPNs).