公开(公告)号：US10385011B2

公开(公告)日：2019-08-20

申请号：US15561585

申请日：2016-03-30

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup Joo ,  Soo Jeong Choi ,  Heung Soo Baek ,  Chang Seok Lee ,  Jeong Hwan Kim ,  Yongjin Kim ,  Hong-Ju Shin ,  Ho Sik Rho ,  Song Seok Shin ,  Jon Hwan Lee

IPC: A61K31/16 ,  C07C231/12 ,  C07C233/70 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/02 ,  A23L29/00 ,  C07C235/48

Abstract: Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. The novel compound and the like inhibit melanin production, prevent tyrosinase activity, and have an excellent skin whitening effect.

公开(公告)号：US10208009B2

公开(公告)日：2019-02-19

申请号：US15780421

申请日：2016-11-30

Applicant: AMOREPACIFIC CORPORATION

Inventor： Ho Sik Rho ,  Jae Won Yoo ,  Yong Jin Kim

IPC: C07D309/40 ,  A61Q19/08 ,  A61K8/49 ,  C07D309/34

Abstract: The present invention relates to a novel hydroxyl pyranone compound, a method for producing same, and a cosmetic composition having the compound. The hydroxyl pyranone compound according to the present invention exhibits markedly improved effectiveness compared to the conventional adipocyte differentiation-promoting material, and thus is preferably included as an active ingredient in a cosmetic composition for increasing skin volume or elasticity.

公开(公告)号：US10238624B2

公开(公告)日：2019-03-26

申请号：US15563119

申请日：2016-03-28

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyun Jung Kim ,  Ji Hyun Kim ,  Jue Won Kim ,  Ho Sik Rho ,  Hyun Seo Kang

IPC: A61K31/351 ,  A61K31/35 ,  A61K31/36 ,  A61K8/49 ,  A61Q19/00

Abstract: Disclosed is a composition for activating longevity genes, particularly, a Sirt-1, Klotho, XPD, ERCC8 or FoxO3a gene, containing a kojic acid derivative as an active ingredient. The composition activates longevity genes, thereby having anticancer, lifetime extension, skin moisturization or skin barrier strengthening effects.

公开(公告)号：US10183926B1

公开(公告)日：2019-01-22

申请号：US16064764

申请日：2016-12-15

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup Joo ,  Jae Won Yoo ,  Yong Jin Kim ,  Ho Sik Rho ,  John Hwan Lee

IPC: C07D311/72 ,  A61K8/68 ,  A61Q17/00 ,  A61Q19/00

Abstract: The present invention relates to a pseudo-ceramide compound and a method for preparing the same. The pseudo-ceramide compound of the present invention may provide antioxidant effects, and exhibits improved properties such as high solubility compared to existing natural ceramides and pseudo-ceramide compounds, and therefore, may be included in large quantities in the formulation. Accordingly, the pseudo-ceramide compound may be used in various fields such as cosmetics, medicinal substances, external preparations and foods.

公开(公告)号：US10570087B2

公开(公告)日：2020-02-25

申请号：US16336893

申请日：2017-09-14

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup Joo ,  Jae Won Yoo ,  Yong Jin Kim ,  Ho Sik Rho ,  John Hwan Lee

IPC: C07C235/06 ,  C07C231/02 ,  C07B51/00 ,  C07D319/06

Abstract: The present invention relates to a pseudo-ceramide compound and a preparation method therefor. According to the present invention, the pseudo-ceramide compound has a molecular structure and a function similar to those of a natural ceramide, can be readily synthesized, and has excellent solubility in an organic solvent and excellent stability, and thus the pseudo-ceramide compound can be used as an alternative to a natural ceramide. Therefore, the pseudo-ceramide compound of the present invention can be widely applied to a skin preparation for external use, a cosmetic composition, and the like for reinforcing and maintaining a skin barrier function.

公开(公告)号：US10259799B2

公开(公告)日：2019-04-16

申请号：US15780412

申请日：2016-11-28

Applicant: AMOREPACIFIC CORPORATION

Inventor： Ho Sik Rho ,  Jae Won Yoo ,  Yong Jin Kim

IPC: A61K8/49 ,  A61Q19/08 ,  C07D309/40

Abstract: The present invention relates to a novel hydroxyl pyranone compound, a method for producing same, and a cosmetic composition having the compound. The hydroxyl pyranone compound according to the present invention exhibits markedly improved effectiveness compared to the conventional adipocyte differentiation-promoting material, and thus is preferably included as an active ingredient in a cosmetic composition for increasing skin volume or elasticity.

公开(公告)号：US10251862B2

公开(公告)日：2019-04-09

申请号：US15107955

申请日：2015-01-20

Applicant: AMOREPACIFIC CORPORATION

Inventor： Ho Sik Rho ,  Heung Soo Baek ,  Yu Jung Kim ,  Song Seok Shin ,  John Hwan Lee

IPC: A61K31/357 ,  A61K31/36 ,  A61K8/49 ,  A61Q19/00 ,  A61Q19/08

Abstract: The present invention relates to a cosmetic composition containing a hydroxypyranone derivative compound as an active ingredient for promoting the differentiation of adipocytes. The composition according to the present invention has an effect of promoting the differentiation of adipocytes, and thus allows the differentiation of adipocyte in a skin layer, thereby increasing the skin volume or elasticity. Therefore, the composition of the present invention can be variously used as a cosmetic composition or a pharmaceutical composition in the field, such as skin damage.

公开(公告)号：US08906433B2

公开(公告)日：2014-12-09

申请号：US13892481

申请日：2013-05-13

Applicant: Amorepacific Corporation

Inventor： Jeong Cheol Ha ,  Lee Kyoung Kwon ,  Youn Joon Kim ,  Ho Sik Rho ,  Sang Hoon Han

IPC: A61K36/15 ,  A61K36/00 ,  A61K8/97 ,  A61Q19/00

CPC classification number: A61K8/97 ,  A61Q19/00 ,  A61Q19/007

Abstract: The present invention relates to a skin moisturizing cosmetic composition that includes a pine resin extract, a Pinus Densiflora needle extract, and a Pinus Densiflora root extract, as active ingredients. More specifically, the present invention includes a pine resin extract, a Pinus Densiflora needle extract, and a Pinus Densiflora root extract, as active ingredients, and has advantageous effects of improving moisturizing activity on the skin and enhancing skin texture, skin clearness and skin contour.

Abstract translation: 本发明涉及一种皮肤保湿化妆品组合物，其包含松树树脂提取物，松属松提取物和松属根提取物作为活性成分。 更具体地说，本发明包括作为活性成分的松树脂提取物，松属松提取物和松属根提取物，并且具有改善对皮肤的保湿活性和增强皮肤纹理，皮肤清晰度和皮肤轮廓的有益效果 。

公开(公告)号：US08828456B2

公开(公告)日：2014-09-09

申请号：US13756227

申请日：2013-01-31

Applicant: Amorepacific Corporation

Inventor： Ho Sik Rho ,  Eun Joo Kim ,  Ga Young Cho ,  Hye Yoon Park ,  Ji Seong Kim ,  Duck Hee Kim ,  Han Kon Kim

IPC: A61K36/00 ,  A61K8/97 ,  A61Q19/00 ,  A61Q17/04 ,  A61Q19/08

CPC classification number: A61K8/97 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08

Abstract: The present invention relates to a composition for skin external application containing a pine root extract. More specifically, the composition for skin external application according to the present invention contains, as an active ingredient, a pine root extract which shows various effects, including eliminating free radicals, protecting the cell membrane from damage by UV radiation, inhibiting the production of reactive oxygen species caused by UV radiation, inhibiting the reduction in the expression of superoxide dismutase (SOD) and catalase caused by UV radiation, stimulating the production of HSP70 to protect cells, inhibiting MMP-2 biosynthesis caused by UV radiation, inducing the expression of SIRT1 gene that restores DNA damage, and inducing the expression of LMNA1 gene that maintains the structure of the nuclear membrane. Ultimately, the composition of the present invention prevents skin aging.

Abstract translation: 本发明涉及含有松根提取物的皮肤外用组合物。 更具体地，根据本发明的皮肤外用组合物含有作为活性成分的松果提取物，其显示各种效果，包括消除自由基，保护细胞膜免受紫外线辐射的损伤，抑制反应性的生成 由紫外线引起的氧物质，抑制由紫外线辐射引起的超氧化物歧化酶（SOD）和过氧化氢酶的表达的降低，刺激HSP70的产生以保护细胞，抑制由UV辐射引起的MMP-2生物合成，诱导SIRT1的表达 基因，其恢复DNA损伤，并诱导维持核膜结构的LMNA1基因的表达。 最终，本发明的组合物可防止皮肤老化。