公开(公告)号：US09433593B1

公开(公告)日：2016-09-06

申请号：US15085628

申请日：2016-03-30

Applicant: Amorepacific Corporation

Inventor： Yung Hyup Joo ,  Heung Soo Baek ,  Jeong Hwan Kim ,  Chang Geun Yi ,  Hyung Jun Lim ,  Hong-Ju Shin ,  Yongjin Kim ,  Jon Hwan Lee

IPC: A61K31/166 ,  A61K9/20 ,  A61K9/16 ,  A61K9/06 ,  A23L1/30 ,  A61K9/00

CPC classification number: A61K31/166 ,  A23G1/42 ,  A23G3/36 ,  A23G4/12 ,  A23G9/36 ,  A23L33/00 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/1652 ,  A61K9/2059

Abstract: 5-Adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide disclosed in the present disclosure lacks toxicity and can exhibit superior anti-inflammatory effect. It exhibits superior anti-inflammatory effect, for example, by inhibiting the production of one or more of NO and PGE2, by inhibiting the activity of one or more of the transcription factors NF-κB and AP-1 or by inhibiting proinflammatory cytokines such as IL-1β.

Abstract translation: 本发明公开的5-金刚烷-1-基-N-（2,4-二羟基苄基）-2,4-二甲氧基苯甲酰胺缺乏毒性，可表现出优异的抗炎作用。 通过抑制一种或多种转录因子NF-κB和AP-1的活性或通过抑制促炎细胞因子，例如通过抑制NO和PGE2中的一种或多种的产生，显示出优异的抗炎作用 IL-1β。

公开(公告)号：US10470996B2

公开(公告)日：2019-11-12

申请号：US15562567

申请日：2016-03-28

Applicant: AMOREPACIFIC CORPORATION ,  INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS

Inventor： Hyung Jun Lim ,  Yong Jin Kim ,  Jon Hwan Lee ,  Jin Woong Kim ,  Ji Eun Kim

IPC: A61K8/02 ,  A61K8/04 ,  A61K8/81 ,  A61K8/87 ,  A61Q19/00

Abstract: The present invention provides: a colloid having a self-iontophoresis capacity, comprising elastomer microparticles and a piezoelectric layer encompassing the same; a preparation method therefor; and a cosmetic composition containing the same.According to the present invention, iontophoresis occurs by itself without the help of additional instruments, thereby allowing water-soluble active ingredients in a cosmetic composition to be effectively and transdermally delivered and absorbed.

公开(公告)号：US10278903B2

公开(公告)日：2019-05-07

申请号：US15555863

申请日：2015-11-24

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyun Suk Lee ,  Yong Jin Kim ,  Jon Hwan Lee ,  Se Jun Park ,  Kyung Ho Choi ,  Yeong Jin Choi ,  Sung-Wook Choi ,  Dong-Hyun Paik

IPC: A61K8/29 ,  A61K8/02 ,  A61K8/27 ,  A61K8/19 ,  A61K8/81 ,  A61Q1/02 ,  C08J3/12 ,  A61K8/26 ,  A61Q1/00 ,  A61Q1/12

Abstract: The present invention relates to composite powder having enhanced water repellency and oil absorbency by means of even impregnation of inorganic powder particles with a super-water-repellent porous polymer. The composite powder prepared by means of a one-step spraying procedure of electro-spraying or spray drying, according to the present invention, shows super water repellency and maximized oil absorbency by means of increased porosity of porous polymethyl methacrylate (PMMA) and even impregnation with titanium dioxide (TiO2) nanoparticles.

公开(公告)号：US10568830B2

公开(公告)日：2020-02-25

申请号：US15514600

申请日：2015-09-24

Applicant: AMOREPACIFIC CORPORATION

Inventor： Pil Joon Park ,  Seung Hyun Shin ,  Hae Kwang Lee ,  Jon Hwan Lee ,  Tae Ryong Lee ,  Eun Gyung Cho

IPC: A61K36/539 ,  A61K8/97 ,  A61Q7/00 ,  A23L33/105 ,  A23L2/52 ,  A61K8/34

Abstract: Disclosed is a novel use of a composition comprising as an active ingredient a Scutellaria alpina extract. A composition according to the present description shows hair follicle cell proliferation or hair growth effect by means of comprising a Scutellaria alpina extract. Therefore, due to said effect, the Scutellaria alpina extract has hair loss prevention or hair growth stimulation effect.

公开(公告)号：US10385011B2

公开(公告)日：2019-08-20

申请号：US15561585

申请日：2016-03-30

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup Joo ,  Soo Jeong Choi ,  Heung Soo Baek ,  Chang Seok Lee ,  Jeong Hwan Kim ,  Yongjin Kim ,  Hong-Ju Shin ,  Ho Sik Rho ,  Song Seok Shin ,  Jon Hwan Lee

IPC: A61K31/16 ,  C07C231/12 ,  C07C233/70 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/02 ,  A23L29/00 ,  C07C235/48

Abstract: Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. The novel compound and the like inhibit melanin production, prevent tyrosinase activity, and have an excellent skin whitening effect.

公开(公告)号：US10172777B2

公开(公告)日：2019-01-08

申请号：US15560879

申请日：2016-03-14

Applicant: AMOREPACIFIC CORPORATION

Inventor： Jae Won You ,  Tae Hun Park ,  Yong-Jin Kim ,  Jon Hwan Lee

IPC: C07H15/12 ,  C07H1/00 ,  A61K8/68 ,  A61P17/10 ,  A61P31/04 ,  A61K8/60 ,  A61K31/133 ,  A61Q19/00 ,  C07C215/10 ,  C07H15/04

Abstract: The present invention relates to a phytospingosine derivative generated by a condensation reaction of phytospingosine and maltose or lactose, which is an aldose-based disaccharide, and to a composition containing the same. The phytospingosine derivative of the present invention has high solubility in water compared with phytospingosine, is easy to formulate since the stabilization problem in a solution is solved, and maintains or further enhances the antibacterial effect of phytospingosine.

公开(公告)号：US11052098B2

公开(公告)日：2021-07-06

申请号：US15779749

申请日：2016-11-30

Applicant: Amorepacific Corporation

Inventor： Jin Sup Shim ,  Jae Young Ko ,  Mi Suk Yang ,  Se Jin Yoo ,  Ho Hyun Song ,  Yong Jin Kim ,  Jon Hwan Lee

IPC: A61K31/704 ,  A61K8/60 ,  A61K9/00 ,  A61Q19/08 ,  A61K9/06

Abstract: The present invention relates to a composition comprising an araloside-based compound and, more particularly, to a composition for external application to skin, the composition comprising, as an active component, an araloside-based compound, including araloside X, araloside V and araloside VII. Thus, the composition restores skin markers damaged by external environmental stress, such as harmful substances or fine dusts, and reduces the expression of skin inflammatory factors to help the recovery of damaged skin, thereby providing effects, such as anti-oxidation, skin trouble suppression, anti-inflammation, or skin barrier improvement.

公开(公告)号：US10967028B2

公开(公告)日：2021-04-06

申请号：US15902042

申请日：2018-02-22

Applicant: AMOREPACIFIC CORPORATION

Inventor： Pil Joon Park ,  Seung Hyun Shin ,  Hae Kwang Lee ,  Jon Hwan Lee ,  Tae Ryong Lee ,  Eun Gyung Cho

IPC: A61K36/539 ,  A61K36/282 ,  A61K8/97 ,  A61Q7/00 ,  A61K9/20 ,  A61K9/08 ,  A61K9/48 ,  A61K9/16 ,  A61K9/00 ,  A61K47/10

Abstract: Disclosed is a novel use of a composition comprising as an active ingredient an Artemisia umbelliformis extract. A composition according to the present description shows hair follicle cell proliferation or hair growth effect by means of comprising an Artemisia umbelliformis extract. Therefore, due to said effect, the Artemisia umbelliformis extract has hair loss prevention or hair growth stimulation effect.

公开(公告)号：US10696611B2

公开(公告)日：2020-06-30

申请号：US15506972

申请日：2015-08-24

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup Joo ,  Song Seok Shin ,  Byoung Young Woo ,  Heung Soo Baek ,  Yong Deog Hong ,  Hong-Ju Shin ,  Yeon Su Jeong ,  Jon Hwan Lee

IPC: C07C239/00 ,  C07D453/02 ,  C07D413/00 ,  A61K31/16 ,  C07C13/615 ,  C07C233/59 ,  A61K31/167 ,  A61K8/42 ,  C07C233/60 ,  A61K8/49 ,  A61Q7/00 ,  A61K31/166 ,  C07C233/63 ,  C07C231/02 ,  C07C233/58 ,  C07C265/12 ,  A61Q19/00 ,  C07D263/56 ,  C07C15/04 ,  C07C233/57 ,  A61K31/4184

Abstract: Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.