公开(公告)号：US20180113121A1

公开(公告)日：2018-04-26

申请号：US15559348

申请日：2015-03-19

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyoung June KIM ,  Min Sik CHOI ,  Ji Yong JUNG ,  Ju Yearl PARK ,  Tae Ryong LEE ,  Dong Wook SHIN ,  Eui Dong SON ,  Min Jung CHAE

IPC: G01N33/52 ,  G01N33/53 ,  G01N33/68

Abstract: Unlike a conventional method for evaluating a degree of ultraviolet protection through visual evaluation, the disclosed method for measuring a sunlight protection function can accurately and objectively measure and determine a degree of sunlight protection by measuring a change due to a material to be measured with respect to an expression amount of skin tissue antimicrobial peptides (AMPs) in skin cells, which decrease from exposure to sunlight, and/or a generation amount of S-nitrosylated protein. Additionally, the disclosed measurement method can determine whether blue/violet light of wavelengths of 400-500 nm, which induces the most skin damage among visible rays, is blocked and provide a more specified sunlight protection effect evaluation result. Moreover, by using the disclosed measurement method, a degree of sunlight protection can be indexed, and a sunlight protection composition for protecting normal skin from the blue/violet light can be provided.

公开(公告)号：US20180044734A1

公开(公告)日：2018-02-15

申请号：US15554886

申请日：2016-04-04

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyoung-June KIM ,  Na Ri CHA ,  Ju Yearl PARK ,  Changjo JUNG ,  Lee-Kyoung KWON ,  Dong Wook SHIN ,  Tae Ryong LEE

IPC: C12Q1/68 ,  A61K31/352 ,  A23L33/00 ,  A61Q19/00 ,  A61Q19/10 ,  A23L33/10 ,  G01N33/68 ,  A61K8/49

CPC classification number: C12Q1/6883 ,  A23L33/10 ,  A23L33/30 ,  A23V2002/00 ,  A61K8/498 ,  A61K31/352 ,  A61Q19/00 ,  A61Q19/10 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/20

Abstract: The present specification discloses a biomarker for diagnosing skin cell damage caused by fine dust, a kit using the same, and a novel use of a composition comprising galangin as an active ingredient. Specifically, it is possible to conveniently check skin damage caused by fine dust by measuring and comparing the expression amounts of the biomarker in normal cells and cells damaged by fine dust. In addition, a composition of the present invention comprising galangin, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof or a solvate thereof as an active ingredient can normalize the gene expression of skin damaged by fine dust and promote differentiation of skin keratinocytes, thereby having a skin moisturizing or skin-barrier strengthening effect. Accordingly, since the composition can be used to prevent, treat, or alleviate skin diseases such as atopy, psoriasis, etc. the composition is useful.