公开(公告)号：US20200246413A1

公开(公告)日：2020-08-06

申请号：US16648946

申请日：2018-08-13

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyoung-June KIM ,  Jinsup SHIM ,  Tae Ryong LEE

IPC: A61K36/736 ,  A61K8/9789 ,  A61Q19/00 ,  A23L33/105 ,  B01D11/02

Abstract: Disclosed in the present specification is a composition comprising a Prunus mume flower extract as an effective ingredient for treating fine dust-caused skin damage, wherein the expression of IL-36G (NM 019618), which is a gene having an expression level affected by fine dust in skin cells, is regulated to a novel level. By using the composition for treating fine dust-caused skin damage, gene expression changed by fine dust can return to a normal level to treat skin cell damage.

公开(公告)号：US20200261351A1

公开(公告)日：2020-08-20

申请号：US16651878

申请日：2018-08-23

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyoung-June KIM ,  Kyeonghwan HWANG ,  Jun Seong PARK ,  Tae Ryong LEE

IPC: A61K8/9789 ,  A61K36/82 ,  A23L33/105 ,  A61Q19/08

Abstract: The present specification discloses a composition for caring for skin damage caused by fine dust, wherein the composition includes a fermented tea extract as an active ingredient and adjusts the expression level of at least one selected from the following group of genes which are present in skin cells and have expression levels that are affected by fine dust to normal levels, said group consisting of: IL-1B (NM_000576), IL-36G (NM_019618), S100A7 (NM_002963), LCE3D (NM_032563), PTGS2 (NM_000963) and XDH (NM_000379). Damage to skin cells can be cared for by using the composition for caring for skin damage caused by fine dust to return gene expression levels, which change due to fine dust, to normal levels.

公开(公告)号：US20180044734A1

公开(公告)日：2018-02-15

申请号：US15554886

申请日：2016-04-04

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyoung-June KIM ,  Na Ri CHA ,  Ju Yearl PARK ,  Changjo JUNG ,  Lee-Kyoung KWON ,  Dong Wook SHIN ,  Tae Ryong LEE

IPC: C12Q1/68 ,  A61K31/352 ,  A23L33/00 ,  A61Q19/00 ,  A61Q19/10 ,  A23L33/10 ,  G01N33/68 ,  A61K8/49

CPC classification number: C12Q1/6883 ,  A23L33/10 ,  A23L33/30 ,  A23V2002/00 ,  A61K8/498 ,  A61K31/352 ,  A61Q19/00 ,  A61Q19/10 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/20

Abstract: The present specification discloses a biomarker for diagnosing skin cell damage caused by fine dust, a kit using the same, and a novel use of a composition comprising galangin as an active ingredient. Specifically, it is possible to conveniently check skin damage caused by fine dust by measuring and comparing the expression amounts of the biomarker in normal cells and cells damaged by fine dust. In addition, a composition of the present invention comprising galangin, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof or a solvate thereof as an active ingredient can normalize the gene expression of skin damaged by fine dust and promote differentiation of skin keratinocytes, thereby having a skin moisturizing or skin-barrier strengthening effect. Accordingly, since the composition can be used to prevent, treat, or alleviate skin diseases such as atopy, psoriasis, etc. the composition is useful.

公开(公告)号：US20220000734A1

公开(公告)日：2022-01-06

申请号：US17285214

申请日：2019-10-15

Applicant: AMOREPACIFIC CORPORATION

Inventor： Eun Jeong CHOI ,  Hyoung-June KIM ,  Tae Ryong LEE ,  Hyunjung CHOI

IPC: A61K8/365 ,  A61Q19/00 ,  A61Q17/00

Abstract: Provided are a composition including a compound of the following chemical formula as an active ingredient and a method of strengthening the skin barrier by applying it to skin of a subject:

公开(公告)号：US20210038673A1

公开(公告)日：2021-02-11

申请号：US16766158

申请日：2018-11-22

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yeongran LEE ,  Hyoung-June KIM ,  Jun Seong PARK ,  Kyeonghwan HWANG

IPC: A61K36/82 ,  A61K31/704 ,  A61K8/60 ,  A61K8/9789 ,  A61Q19/08 ,  A23L33/105

Abstract: The present specification discloses a composition for external application to skin, containing a tea plant root extract as an active ingredient, for treatment of skin damage caused by fine dust, whereby the expression level of one or more selected from a group consisting of IL-36G (NM_019618), S100A7 (NM_002963), S100A8 (NM_002964) and XDH (NM_000379), which are genes in skin cells the expression level of which is affected by fine dust, is regulated to a normal level.

公开(公告)号：US20200230186A1

公开(公告)日：2020-07-23

申请号：US16651880

申请日：2018-08-20

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyoung-June KIM ,  Tae Ryong LEE

IPC: A61K36/185 ,  A61K8/9789 ,  A61Q19/00 ,  A23L33/105

Abstract: Disclosed is a composition including a Hibiscus syriacus extract as an effective ingredient for treating fine dust-caused skin damage, wherein the expression of at least one selected from the group consisting of IL-36G (NM_019618), PTGS2 (NM_000963), XDH (NM_000379) and S100A7 (NM_002963), which are all genes having the expression levels affected by fine dust in skin cells, is regulated to a normal level and for inhibiting an antibacterial peptide, wherein the expression of the antibacterial peptide S100A7 (NM_002963) is regulated to a normal level. By using the composition for treating fine dust-caused skin damage and the composition for inhibiting an antibacterial peptide, gene expression changed by fine dust can return to a normal level to treat skin cell damage and the increased expression of the antibacterial peptide due to various causes can return to normal level.

公开(公告)号：US20180369114A1

公开(公告)日：2018-12-27

申请号：US16014677

申请日：2018-06-21

Applicant: AMOREPACIFIC CORPORATION

Inventor： Kyu-Han KIM ,  Hyoung-June KIM ,  Tae Ryong LEE

IPC: A61K8/64 ,  A61Q5/08 ,  A61Q19/02

Abstract: The present specification is intended to develop a new substance which exhibits a skin whitening effect and to apply the new substance to a composition for skin whitening, provides a new composition for skin whitening and a new kit for skin whitening which contain TNFSF14 protein and a polynucleotide encoding the TNFSF14 protein and a method of using the same, and thus can contribute to the market expansion and industry development related to the skin whitening field.