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公开(公告)号:US20210353676A1
公开(公告)日:2021-11-18
申请号:US17373194
申请日:2021-07-12
申请人: APDN (B.V.I.), Inc.
IPC分类号: A61K35/17 , C12N5/0781 , A61P35/00 , C12N5/0783 , C12Q1/686 , C12Q1/6897
摘要: The present inventions provides systems and methods to manufacture genetically modified lymphocyte cells via the use of linear DNA expression amplicons, and uses of such genetically modified lymphocyte cells to treat disease. The present invention also provides for the composition of genetically modified lymphocyte cells.
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公开(公告)号:US20180194796A1
公开(公告)日:2018-07-12
申请号:US15870035
申请日:2018-01-12
申请人: APDN (B.V.I.) INC.
IPC分类号: C07H21/04 , C05C1/00 , C07C211/03 , C07C229/16 , C12Q1/686 , C01G49/00
CPC分类号: C07H21/04 , C01G49/00 , C05C1/00 , C05D9/02 , C05G3/00 , C05G3/0035 , C05G3/0041 , C07C211/03 , C07C229/16 , C12Q1/6816 , C12Q1/686 , C12Q2563/185
摘要: The invention pertains to a traceable fertilizer product marked with a nucleic acid marker. The invention further provides for a method of marking a fertilizer product with a nucleic acid marker. In addition, the invention teaches a method of using a nucleic acid marked fertilizer product to identify and validate the origin or authenticity of said fertilizer product and to perform quantitative analysis on the fertilizer product to determine if said fertilizer product has been adulterated, diluted and/or counterfeited.
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公开(公告)号:US20180173810A1
公开(公告)日:2018-06-21
申请号:US15868510
申请日:2018-01-11
申请人: APDN (B.V.I.) INC.
发明人: Judith Murrah , Phidung H. Tran , Maciej B. Szczepanik , MingHwa Benjamin Liang , James A. Hayward
CPC分类号: G06F17/30876 , G06K7/0004 , G06K19/06037 , G06K19/0723
摘要: A system associated with authentication of an object related to a multi-mode marker using a processing device. The processing device performs operations that include detecting a signal associated with a multi-mode marker related with the object; assigning a digital code based on the detected signal associated with the multi-mode marker; and identifying the object based on the digital code related to authentication of the object. A corresponding method and computer-readable device are also disclosed.
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公开(公告)号:US09904734B2
公开(公告)日:2018-02-27
申请号:US15027454
申请日:2014-10-07
申请人: APDN (B.V.I.) INC.
发明人: Judith Murrah , Phidung H. Tran , Maciej B. Szczepanik , MingHwa Benjamin Liang , James A. Hayward
CPC分类号: G06F17/30876 , G06K7/0004 , G06K19/06037 , G06K19/0723
摘要: A multi-mode reader instrument capable of detecting and determining digital data from a signal from one or more markers, indicia or taggants on an object, the markers, indicia or taggants such as a bar code, a QR code, an RFID, an optical compound, a fluorescent compound, a phosphorescent compound, a DNA taggant, an upconverting phosphor (UCP), a chemical dye, a digitized image, a radioactive compound, an olfactory compound or a thermal attribute of the object is provided. Also, provided is a method and a system for identifying an object, the system includes: a multi-mode reader instrument for detecting data from a signal from one or more markers, indicia or taggants on an object and assignment of digital code for the marker and a database for securing and retrieving information relevant to the item.
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5.
公开(公告)号:US20170021611A1
公开(公告)日:2017-01-26
申请号:US15049170
申请日:2016-02-22
申请人: APDN (B.V.I.) Inc.
CPC分类号: B41F17/00 , B41M3/14 , B42D25/378 , B42D25/405 , C12Q1/68 , G07D7/14 , Y10T29/49826 , Y10T29/49885
摘要: The invention provides a method of marking an item with naturally-derived or synthetic non-natural polymeric marker molecules, such as a DNA or Peptide marker in conjunction with optional visible or rapid scan reporters for authenticating or tracking, in which the method includes providing an item for marking, and applying a medium including a DNA marker to the item. The invention further provides methods for stably binding and immobilizing activated deoxyribonucleic acid onto objects and substrates. The method includes exposing the deoxyribonucleic acid to alkaline conditions, and contacting the deoxyribonucleic acid to the object or substrate. Also provided are methods for increasing the recoverability of taggants from an object. The methods include the steps of incorporating a taggant into a solution; mixing the solution including the taggant with a perturbant to form a first perturbant taggant solution; mixing the first perturbant taggant solution with a polymer to form a second perturbant taggant polymer solution; and applying the second perturbant taggant polymer solution to at least a portion of the object to form a taggant-coated object. The invention also provides a method of marking an item with a DNA marker for authenticating or tracking, in which the method includes providing a medium including a DNA marker, and molding the medium including the DNA marker to provide all or part of the item. The DNA marker encodes information unique to the item and/or the model of the item as desired.
摘要翻译: 本发明提供了一种使用天然衍生或合成的非天然聚合物标记分子(例如DNA或肽标记)与用于鉴定或跟踪的可选的可见或快速扫描记录器一起标记物品的方法,其中所述方法包括提供 用于标记的项目,以及将包括DNA标记的培养基应用于该物品。 本发明还提供了将活化的脱氧核糖核酸稳定结合并固定在物体和底物上的方法。 该方法包括将脱氧核糖核酸暴露于碱性条件下,并使脱氧核糖核酸与对象或底物接触。 还提供了用于增加标签从对象的可恢复性的方法。 所述方法包括将标签剂掺入溶液中的步骤; 将包含标签剂的溶液与扰动剂混合以形成第一扰动标记剂溶液; 将第一扰动标记剂溶液与聚合物混合以形成第二扰动标记聚合物溶液; 以及将所述第二扰动标记聚合物溶液施加到所述物体的至少一部分以形成标记剂涂覆物体。 本发明还提供了用用于鉴定或追踪的DNA标记物标记物品的方法,其中所述方法包括提供包含DNA标记物的培养基,并且模制包含DNA标记的培养基以提供该物品的全部或部分。 DNA标记根据需要编码项目和/或项目模型唯一的信息。
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公开(公告)号:US20190247437A1
公开(公告)日:2019-08-15
申请号:US16388767
申请日:2019-04-18
申请人: APDN (B.V.I.), Inc.
IPC分类号: A61K35/17 , C12N5/0781 , C12N5/0783 , C12Q1/686 , A61P35/00
CPC分类号: A61K35/17 , A61P35/00 , C12N5/0635 , C12N5/0636 , C12N5/0646 , C12Q1/686
摘要: The present inventions provides systems and methods to manufacture genetically modified lymphocyte cells via the use of linear DNA expression amplicons, and uses of such genetically modified lymphocyte cells to treat disease. The present invention also provides for the composition of genetically modified lymphocyte cells.
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7.
公开(公告)号:US10059981B2
公开(公告)日:2018-08-28
申请号:US15079214
申请日:2016-03-24
申请人: APDN (B.V.I.) Inc.
IPC分类号: C12Q1/68 , C12Q1/6806
CPC分类号: C12Q1/6806 , C12Q1/68 , C12Q2563/185
摘要: The invention provides methods for increasing the recoverability of taggants from an object. The methods include the steps of incorporating a taggant into a solution; mixing the solution including the taggant with a perturbant to form a first perturbant taggant solution; mixing the first perturbant taggant solution with a polymer to form a second perturbant taggant polymer solution; and applying the second perturbant taggant polymer solution to at least a portion of the object to form a taggant-coated object. Methods for authentication of a taggant marked object are also provided.
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公开(公告)号:US10282480B2
公开(公告)日:2019-05-07
申请号:US15868510
申请日:2018-01-11
申请人: APDN (B.V.I.) INC.
发明人: Judith Murrah , Phidung H. Tran , Maciej B. Szczepanik , MingHwa Benjamin Liang , James A. Hayward
摘要: A system associated with authentication of an object related to a multi-mode marker using a processing device. The processing device performs operations that include detecting a signal associated with a multi-mode marker related with the object; assigning a digital code based on the detected signal associated with the multi-mode marker; and identifying the object based on the digital code related to authentication of the object. A corresponding method and computer-readable device are also disclosed.
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公开(公告)号:US20180142294A1
公开(公告)日:2018-05-24
申请号:US15800768
申请日:2017-11-01
申请人: APDN (B.V.I.) INC.
IPC分类号: C12Q1/6876 , G01N33/15 , G09F3/02
CPC分类号: C12Q1/6876 , C12Q1/68 , C12Q1/686 , G01N33/15 , G09F3/02 , G09F2003/0277 , C12Q2563/173 , C12Q2563/185
摘要: Provided is a method of authenticating an active pharmaceutical ingredient (API). The method includes providing an API or an API component and adding a nucleic acid marker having a nucleic acid marker sequence to produce a marked API or a marked API component. The presence of the nucleic acid marker is detected in the sample and the authenticity of the API is thereby determined according to whether the pharmaceutical product includes marked API or the marked API component.
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公开(公告)号:US20170228826A1
公开(公告)日:2017-08-10
申请号:US15427983
申请日:2017-02-08
申请人: APDN (B.V.I.) Inc.
发明人: James A. Hayward , MeiLin Wan
CPC分类号: G06Q40/10 , C12Q1/6816 , G06K19/0614 , C12Q2563/185
摘要: A method and system of identifying articles in commerce including tagging a raw material during said raw material's manufacturing process with a unique molecular marker in a home country in which the raw material was produced. The marker identifies home country information. The tagged raw material is transported from the home country to a foreign country. The tagged raw material is processed in the foreign country to generate a processed product. The processed product is transported to the home country. The processed product is analyzing to determine the presence of the marker in the processed product. A determination is made whether the raw material originated in the home country in response to the detection of the marker.
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