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公开(公告)号：US20150241415A1
公开(公告)日：2015-08-27
申请号：US14421099
申请日：2013-08-09
申请人： ASTUTE MEDICAL, INC. , UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf , Kai Singbartl , John A. Kellum, JR.
IPC分类号： G01N33/53
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients. In particular, the invention relates to using assays that detect hyaluronic acid as diagnostic and prognostic biomarker assays of renal injury in the sepsis patient.
摘要翻译： 本发明涉及用于监测，诊断，预后和确定败血症患者治疗方案的方法和组合物。 特别地，本发明涉及使用检测透明质酸作为脓毒症患者肾损伤的诊断和预后生物标志物测定的测定法。
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公开(公告)号：US11243217B2
公开(公告)日：2022-02-08
申请号：US16307366
申请日：2017-06-06
IPC分类号： G01N33/74 , G01N33/493 , G01N33/68
摘要： The present invention provides methods and compositions for identifying patients at risk of kidney injury. A risk score, which is a composite of a urinary concentration of IGFBP7 (insulin-like growth factor-binding protein 7) and a urinary concentration of TIMP-2 (tissue inhibitor of metalloproteinase 2), is determined obtained from the patient, and is used to manage patient treatment.
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公开(公告)号：US20160282344A1
公开(公告)日：2016-09-29
申请号：US15036805
申请日：2014-11-15
申请人： ASTUTE MEDICAL, INC. , UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf , Thomas Kwan , John A. Kellum , Derek C. Angus
IPC分类号： G01N33/569
CPC分类号： G01N33/56911 , G01N33/6893 , G01N2333/47 , G01N2333/4724 , G01N2333/745 , G01N2333/78 , G01N2333/8128 , G01N2333/96463 , G01N2800/26 , G01N2800/52
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients and in patients at risk for sepsis. In particular, the invention relates to using assays that detect one or more biomarkers as diagnostic and prognostic biomarker assays in such patients.
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公开(公告)号：US11353465B2
公开(公告)日：2022-06-07
申请号：US16475326
申请日：2018-01-12
申请人： ASTUTE MEDICAL, INC.
IPC分类号： G01N33/68
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect C-C motif chemokine 14 as diagnostic and prognostic biomarker assays in renal injuries.
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公开(公告)号：US11333671B2
公开(公告)日：2022-05-17
申请号：US15520817
申请日：2015-10-20
申请人： ASTUTE MEDICAL, INC.
发明人： Joseph Anderberg , Paul McPherson , Jeff Gray , Kevin Nakamura , James Patrick Kampf , Thomas Kwan
IPC分类号： G01N33/68
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect C—C motif chemokine 16, C—C motif chemokine 14, and Tyrosine-protein kinase receptor UFO as diagnostic and prognostic biomarker assays in renal injuries.
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公开(公告)号：US10794917B2
公开(公告)日：2020-10-06
申请号：US15023357
申请日：2014-09-19
申请人： ASTUTE MEDICAL, INC.
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf , Thomas Kwan
IPC分类号： G01N33/68
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in appendicitis patients and in patients at risk for appendicitis. In particular, the invention relates to using assays that detect one or more biomarkers as diagnostic and prognostic biomarker assays in such patients.
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公开(公告)号：US10473671B2
公开(公告)日：2019-11-12
申请号：US15537361
申请日：2015-12-18
申请人： ASTUTE MEDICAL, INC.
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Chitinase-3-like protein 1 as diagnostic and prognostic biomarker assays in renal injuries.
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8.发明申请公开(公告)号：US20170363642A1
公开(公告)日：2017-12-21
申请号：US15537361
申请日：2015-12-18
申请人： ASTUTE MEDICAL, INC.
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2030/8813 , G01N2333/4724 , G01N2800/347
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Chitinase-3-like protein 1 as diagnostic and prognostic biomarker assays in renal injuries.
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9.发明申请公开(公告)号：US20170254816A1
公开(公告)日：2017-09-07
申请号：US15604573
申请日：2017-05-24
申请人： ASTUTE MEDICAL, INC.
CPC分类号： G01N33/6893 , G01N33/6854 , G01N33/6863 , G01N33/74 , G01N2333/4725 , G01N2333/4745 , G01N2333/495 , G01N2333/521 , G01N2333/5431 , G01N2333/7155 , G01N2333/96472 , G01N2333/96494 , G01N2800/347 , G01N2800/50 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Cancer antigen CA 15-3, C-C Motif chemokine 18, C-C Motif chemokine 24, Cathepsin D, C-X-C Motif chemokine 13, C-C motif chemokine 8, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, Interleukin-11, Matrix Metalloproteinase-8, Transforming growth factor alpha, IgG1, and IgG2 as diagnostic and prognostic biomarkers in renal injuries.
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10.发明申请METHODS AND COMPOSITIONS FOR THE EVALUATION OF RENAL INJURY USING HYALURONIC ACID 审中-公开使用羟丙酸评估肾损伤的方法和组合公开(公告)号：US20170074868A1
公开(公告)日：2017-03-16
申请号：US15345255
申请日：2016-11-07
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf , Kai Singbartl , John A. Kellum
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N2400/40 , G01N2800/347
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of hyaluronic acid (HA) as diagnostic and prognostic biomarker assays in renal injuries.
摘要翻译： 本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用检测透明质酸（HA）中的一种或多种作为肾损伤中的诊断和预后生物标志物测定的测定法。
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