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公开(公告)号：US09809576B1
公开(公告)日：2017-11-07
申请号：US14802372
申请日：2015-07-17
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C69/74 , C07D241/44 , C07D405/06 , C07C271/34 , C07C67/08 , C07D405/14 , C07D487/04 , C07C269/06 , C07C269/04 , C07C41/26 , C07C43/196
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US20190084966A1
公开(公告)日：2019-03-21
申请号：US16132997
申请日：2018-09-17
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C269/06 , C07C68/02 , C07C67/08 , C07C211/35 , C07C271/34 , C12P1/00 , C07C69/74 , C07C43/196 , C07C41/26 , C07D405/14 , C07D241/44 , C07D405/06 , C07D487/04 , C07C269/04
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C12P41/005 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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3.发明申请公开(公告)号：US20160152600A1
公开(公告)日：2016-06-02
申请号：US15000017
申请日：2016-01-18
Applicant: AbbVie Inc.
Inventor： Todd S. McDermott , Seble H. Wagaw , Kenneth M. Engstrom , Jorge Gandarilla , Albert Kruger , Michael J. Rozema , Michael G. Fickes , Steven J. Wittenberger , Lakshmi Bhagavatula , Thomas B. Borchardt
IPC: C07D401/14 , C07F7/08 , C07D207/16 , C07D401/04 , C07D213/803
CPC classification number: C07D401/14 , C07D207/16 , C07D213/803 , C07D401/04 , C07F7/0803
Abstract: A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are disclosed.
Abstract translation: 制备（2S，5R）-5-乙炔基-1- {N-（4-甲基-1-（4-羧基 - 吡啶-2-基）哌啶-4-基）甘氨酰基}吡咯烷-2-甲腈 及其盐，以及该方法中使用的中间体。
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Patent Agency Ranking
公开(公告)号：US20140100364A1
公开(公告)日：2014-04-10
申请号：US14047440
申请日：2013-10-07
Applicant: AbbVie Inc.
Inventor： Kenneth M. Engstrom , Yanqun Zhao
IPC: C07D498/16 , C07D417/14 , C07D487/04 , C07D498/06
CPC classification number: C07D498/16 , C07D403/12 , C07D417/14 , C07D487/04 , C07D498/06 , C07D498/08 , C07D498/18
Abstract: Compounds useful for making HCV protease inhibitors are described. Methods of using these compounds to make HCV protease inhibitors are also provided.
Abstract translation: 描述了可用于制备HCV蛋白酶抑制剂的化合物。 还提供了使用这些化合物制备HCV蛋白酶抑制剂的方法。
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公开(公告)号：US20200095230A1
公开(公告)日：2020-03-26
申请号：US16586401
申请日：2019-09-27
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07D405/14 , C07D241/44 , C07D405/06 , C07C271/34 , C07C69/74 , C07C43/196 , C07D487/04 , C07C269/06 , C07C269/04 , C07C41/26 , C07C67/08 , C07C68/02 , C07C211/35 , C12P1/00 , C12P41/00
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US10077256B2
公开(公告)日：2018-09-18
申请号：US15804485
申请日：2017-11-06
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C67/08 , C07C41/26 , C07C269/04 , C07C269/06 , C07D487/04 , C07C43/196 , C07C69/74 , C07C271/34 , C07D405/06 , C07D241/44 , C07D405/14
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C12P41/005 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US10442792B2
公开(公告)日：2019-10-15
申请号：US16132997
申请日：2018-09-17
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07D405/14 , C07D241/44 , C07D405/06 , C07C271/34 , C07C43/196 , C07D487/04 , C07C269/06 , C07C41/26 , C07C67/08 , C07C68/02 , C12P1/00 , C07C211/35 , C12P41/00 , C07C69/74 , C07C269/04
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US20180057482A1
公开(公告)日：2018-03-01
申请号：US15804485
申请日：2017-11-06
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C67/08 , C07C41/26 , C07C269/04 , C07C269/06 , C07D487/04 , C07C69/74 , C07C271/34 , C07D405/06 , C07D241/44 , C07D405/14 , C07C43/196
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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