Patent search ap:("AbbVie Inc.") AND inv:"Russell D. Cink" Page 1

1.

发明申请
SYNTHETIC ROUTE TO ANTI-VIRAL AGENTS 审中-公开

公开(公告)号：US20190084966A1

公开(公告)日：2019-03-21

申请号：US16132997

申请日：2018-09-17

Applicant: AbbVie Inc.

Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill

IPC: C07D403/12 , C07C269/06 , C07C68/02 , C07C67/08 , C07C211/35 , C07C271/34 , C12P1/00 , C07C69/74 , C07C43/196 , C07C41/26 , C07D405/14 , C07D241/44 , C07D405/06 , C07D487/04 , C07C269/04

CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C12P41/005 , C07C69/96 , C07C69/14

Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

2.

发明申请
MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS 有权
Title translation: 大肠杆菌C型丝氨酸蛋白酶抑制剂

公开(公告)号：US20140287992A1

公开(公告)日：2014-09-25

申请号：US14299095

申请日：2014-06-09

Applicant: Enanta Pharmaceuticals, Inc. , AbbVie, Inc.

Inventor： Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarilla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or

IPC: C07K5/083

CPC classification number: C07K5/081 , C07D487/04

Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

Abstract translation: 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。

3.

发明授权
Synthetic route to anti-viral agents 有权

公开(公告)号：US10442792B2

公开(公告)日：2019-10-15

申请号：US16132997

申请日：2018-09-17

Applicant: AbbVie Inc.

Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill

IPC: C07D403/12 , C07D405/14 , C07D241/44 , C07D405/06 , C07C271/34 , C07C43/196 , C07D487/04 , C07C269/06 , C07C41/26 , C07C67/08 , C07C68/02 , C12P1/00 , C07C211/35 , C12P41/00 , C07C69/74 , C07C269/04

Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

4.

发明申请
SYNTHETIC ROUTE TO ANTI-VIRAL AGENTS 审中-公开

公开(公告)号：US20180057482A1

公开(公告)日：2018-03-01

申请号：US15804485

申请日：2017-11-06

Applicant: AbbVie Inc.

Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill

IPC: C07D403/12 , C07C67/08 , C07C41/26 , C07C269/04 , C07C269/06 , C07D487/04 , C07C69/74 , C07C271/34 , C07D405/06 , C07D241/44 , C07D405/14 , C07C43/196

CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C07C69/96 , C07C69/14

Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

5.

发明授权
Enzymatic processes for the preparation of (±)-2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acid and (±)-2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acid 有权

公开(公告)号：US10689675B2

公开(公告)日：2020-06-23

申请号：US15886318

申请日：2018-02-01

Applicant: AbbVie Inc.

Inventor： Michael J. Abrahamson , Sanjay R. Chemburkar , Angelica B. Kielbus , Russell D. Cink

IPC: C12P7/62 , C12P7/40 , C12N9/18 , C07C67/343

Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.

6.

发明申请
ENZYMATIC PROCESSES FOR THE PREPARATION OF (±)-2-(DIFLUOROMETHYL)-1-(ALKOXYCARBONYL)-CYCLOPROPANECARBOXYLIC ACID AND (±)-2-(VINYL)-1-(ALKOXYCARBONYL)-CYCLOPROPANECARBOXYLIC ACID 审中-公开

公开(公告)号：US20180258451A1

公开(公告)日：2018-09-13

申请号：US15886318

申请日：2018-02-01

Applicant: AbbVie Inc.

Inventor： Michael J. Abrahamson , Sanjay R. Chemburkar , Angelica B. Kielbus , Russell D. Cink

IPC: C12P7/62 , C12N9/18

Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.

7.

发明授权
Synthetic route to anti-viral agents 有权

公开(公告)号：US09809576B1

公开(公告)日：2017-11-07

申请号：US14802372

申请日：2015-07-17

Applicant: AbbVie Inc.

Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill

IPC: C07D403/12 , C07C69/74 , C07D241/44 , C07D405/06 , C07C271/34 , C07C67/08 , C07D405/14 , C07D487/04 , C07C269/06 , C07C269/04 , C07C41/26 , C07C43/196

CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C07C69/96 , C07C69/14

Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

8.

发明申请
ENZYMATIC PROCESSES FOR THE PREPARATION OF (±)-2-(DIFLUOROMETHYL)-1-(ALKOXYCARBONYL)-CYCLOPROPANECARBOXYLIC ACID AND (±)-2-(VINYL)-1-(ALKOXYCARBONYL)-CYCLOPROPANECARBOXYLIC ACID 有权

公开(公告)号：US20210087592A1

公开(公告)日：2021-03-25

申请号：US16871848

申请日：2020-05-11

Applicant: AbbVie Inc.

Inventor： Michael J. Abrahamson , Sanjay R. Chemburkar , Angelica B. Kielbus , Russell D. Cink

IPC: C12P7/62 , C12N9/18 , C07C67/343

Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.