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公开(公告)号：US20190084966A1
公开(公告)日：2019-03-21
申请号：US16132997
申请日：2018-09-17
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C269/06 , C07C68/02 , C07C67/08 , C07C211/35 , C07C271/34 , C12P1/00 , C07C69/74 , C07C43/196 , C07C41/26 , C07D405/14 , C07D241/44 , C07D405/06 , C07D487/04 , C07C269/04
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C12P41/005 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US20200095230A1
公开(公告)日：2020-03-26
申请号：US16586401
申请日：2019-09-27
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07D405/14 , C07D241/44 , C07D405/06 , C07C271/34 , C07C69/74 , C07C43/196 , C07D487/04 , C07C269/06 , C07C269/04 , C07C41/26 , C07C67/08 , C07C68/02 , C07C211/35 , C12P1/00 , C12P41/00
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US10077256B2
公开(公告)日：2018-09-18
申请号：US15804485
申请日：2017-11-06
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C67/08 , C07C41/26 , C07C269/04 , C07C269/06 , C07D487/04 , C07C43/196 , C07C69/74 , C07C271/34 , C07D405/06 , C07D241/44 , C07D405/14
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C12P41/005 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US20180194721A1
公开(公告)日：2018-07-12
申请号：US15789133
申请日：2017-10-20
Applicant: AbbVie Inc.
Inventor： Kirill A. Lukin , Jianzhang Mei , David R. Hill , Michael J. Abrahamson
IPC: C07C271/24 , C12P7/62 , C07C269/06 , C07C67/333 , C07C67/347 , C07C69/74
Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US09809534B1
公开(公告)日：2017-11-07
申请号：US14802392
申请日：2015-07-17
Applicant: AbbVie Inc.
Inventor： Kirill A. Lukin , Jianzhang Mei , David R. Hill , Michael J. Abrahamson
IPC: C07C271/24 , C07C269/06 , C07C69/74 , C07C67/333 , C07C67/347 , C12P7/62
CPC classification number: C07C271/24 , C07B2200/07 , C07C67/333 , C07C67/347 , C07C69/65 , C07C69/74 , C07C211/27 , C07C211/35 , C07C269/00 , C07C269/06 , C07C269/08 , C07C2601/02 , C07C2601/14 , C12P7/62
Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
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Patent Agency Ranking
公开(公告)号：US09809576B1
公开(公告)日：2017-11-07
申请号：US14802372
申请日：2015-07-17
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C69/74 , C07D241/44 , C07D405/06 , C07C271/34 , C07C67/08 , C07D405/14 , C07D487/04 , C07C269/06 , C07C269/04 , C07C41/26 , C07C43/196
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US10442792B2
公开(公告)日：2019-10-15
申请号：US16132997
申请日：2018-09-17
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07D405/14 , C07D241/44 , C07D405/06 , C07C271/34 , C07C43/196 , C07D487/04 , C07C269/06 , C07C41/26 , C07C67/08 , C07C68/02 , C12P1/00 , C07C211/35 , C12P41/00 , C07C69/74 , C07C269/04
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US10421712B2
公开(公告)日：2019-09-24
申请号：US15789133
申请日：2017-10-20
Applicant: AbbVie Inc.
Inventor： Kirill A. Lukin , Jianzhang Mei , David R. Hill , Michael J. Abrahamson
IPC: C12P7/62 , C07C69/65 , C07C69/74 , C07C211/27 , C07C211/35 , C07C269/00 , C07C269/06 , C07C269/08 , C07C271/24 , C07C67/333 , C07C67/347
Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US20180057482A1
公开(公告)日：2018-03-01
申请号：US15804485
申请日：2017-11-06
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C67/08 , C07C41/26 , C07C269/04 , C07C269/06 , C07D487/04 , C07C69/74 , C07C271/34 , C07D405/06 , C07D241/44 , C07D405/14 , C07C43/196
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US09346785B2
公开(公告)日：2016-05-24
申请号：US13739174
申请日：2013-01-11
Applicant: AbbVie Inc.
Inventor： Kirill A. Lukin
IPC: C07D231/56 , C07D207/00 , C07D295/00 , C07D221/12 , C07D401/14 , C07K5/083 , C07K5/078 , C07D401/12
CPC classification number: C07D401/14 , C07D231/56 , C07D401/12 , C07K5/06165 , C07K5/0808 , Y02P20/582
Abstract: Efficient processes for making HCV protease inhibitors are described. In one embodiment, the process uses novel idazolide derivatives of vinyl-ACCA. In another embodiment, the process comprises reacting with to form In still another embodiment, the process comprises coupling with to form
Abstract translation: 描述了制备HCV蛋白酶抑制剂的有效方法。 在一个实施方案中，该方法使用乙烯基-ACCA的新颖的恶唑烷衍生物。 在另一个实施方案中，该方法包括与至形成反应。在另一个实施方案中，该方法包括与形成物的偶联
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