公开(公告)号：US20150093784A1

公开(公告)日：2015-04-02

申请号：US14570685

申请日：2014-12-15

Applicant: AbbVie Inc.

Inventor： Itzcoatl A. Pla ,  Joseph G. Matuck ,  John C. Fann ,  Christof Schulz ,  Nichole A. Roy ,  David F. Bruton ,  James McIntire ,  Yu-Hsiang D. Chang ,  Thomas Seewoester

IPC: C12N5/00 ,  C07K16/24

CPC classification number: C12N5/0037 ,  C07K16/241 ,  C07K16/244 ,  C07K16/2863 ,  C07K2317/14 ,  C07K2317/21 ,  C12N5/0043 ,  C12N2500/24 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2500/60 ,  C12N2500/74 ,  C12N2500/76 ,  C12N2501/105 ,  C12N2501/33

Abstract: The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.

公开(公告)号：US20160186130A1

公开(公告)日：2016-06-30

申请号：US15069456

申请日：2016-03-14

Applicant: AbbVie Inc.

Inventor： Itzcoatl A. Pla ,  Joseph G. Matuck ,  John C. Fann ,  Christof Schulz ,  Nichole A. Roy ,  David F. Bruton ,  James McIntire ,  Yu-Hsiang D. Chang ,  Thomas Seewoester

IPC: C12N5/00

CPC classification number: C12N5/0037 ,  C07K16/00 ,  C07K16/241 ,  C07K16/244 ,  C07K16/2869 ,  C07K2317/14 ,  C07K2317/21 ,  C12N5/0031 ,  C12N5/0603 ,  C12N2500/24 ,  C12N2500/25 ,  C12N2500/30 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2500/50 ,  C12N2500/60 ,  C12N2500/74 ,  C12N2500/76 ,  C12N2500/90 ,  C12N2501/10 ,  C12N2501/33 ,  C12N2510/02 ,  C12N2511/00

Abstract: The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.

公开(公告)号：US09284371B2

公开(公告)日：2016-03-15

申请号：US14920452

申请日：2015-10-22

Applicant: AbbVie Inc.

Inventor： Itzcoatl A. Pla ,  Joseph G. Matuck ,  John C. Fann ,  Christof Schulz ,  Nichole A. Roy ,  David F. Bruton ,  James McIntire ,  Yu-Hsiang D. Chang ,  Thomas Seewoester

IPC: C07K16/24

CPC classification number: C12N5/0037 ,  C07K16/00 ,  C07K16/241 ,  C07K16/244 ,  C07K16/2869 ,  C07K2317/14 ,  C07K2317/21 ,  C12N5/0031 ,  C12N5/0603 ,  C12N2500/24 ,  C12N2500/25 ,  C12N2500/30 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2500/50 ,  C12N2500/60 ,  C12N2500/74 ,  C12N2500/76 ,  C12N2500/90 ,  C12N2501/10 ,  C12N2501/33 ,  C12N2510/02 ,  C12N2511/00

Abstract: The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.

Abstract translation: 本发明描述了用于在哺乳动物细胞培养物中产生重组蛋白例如抗体的改进的方法和组合物。 此外，本发明提供改进的细胞培养基，包括改良的生产培养基，饲料溶液和组合饲料，其可用于改善哺乳动物细胞培养物中的蛋白质生产力。

公开(公告)号：US20160039927A1

公开(公告)日：2016-02-11

申请号：US14920452

申请日：2015-10-22

Applicant: AbbVie Inc.

Inventor： Itzcoatl A. Pla ,  Joseph G. Matuck ,  John C. Fann ,  Christof Schulz ,  Nichole A. Roy ,  David F. Bruton ,  James McIntire ,  Yu-Hsiang D. Chang ,  Thomas Seewoester

IPC: C07K16/24

CPC classification number: C12N5/0037 ,  C07K16/00 ,  C07K16/241 ,  C07K16/244 ,  C07K16/2869 ,  C07K2317/14 ,  C07K2317/21 ,  C12N5/0031 ,  C12N5/0603 ,  C12N2500/24 ,  C12N2500/25 ,  C12N2500/30 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2500/50 ,  C12N2500/60 ,  C12N2500/74 ,  C12N2500/76 ,  C12N2500/90 ,  C12N2501/10 ,  C12N2501/33 ,  C12N2510/02 ,  C12N2511/00

Abstract: The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.

公开(公告)号：US09090867B2

公开(公告)日：2015-07-28

申请号：US14570685

申请日：2014-12-15

Applicant: AbbVie Inc.

Inventor： Itzcoatl A. Pla ,  Joseph G. Matuck ,  John C. Fann ,  Christof Schulz ,  Nichole A. Roy ,  David F. Bruton ,  James McIntire ,  Yu-Hsiang D. Chang ,  Thomas Seewoester

IPC: C12N5/00 ,  C07K16/24 ,  C07K16/28

CPC classification number: C12N5/0037 ,  C07K16/241 ,  C07K16/244 ,  C07K16/2863 ,  C07K2317/14 ,  C07K2317/21 ,  C12N5/0043 ,  C12N2500/24 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2500/60 ,  C12N2500/74 ,  C12N2500/76 ,  C12N2501/105 ,  C12N2501/33

Abstract: The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.

Abstract translation: 本发明描述了用于在哺乳动物细胞培养物中产生重组蛋白例如抗体的改进的方法和组合物。 此外，本发明提供改进的细胞培养基，包括改良的生产培养基，饲料溶液和组合饲料，其可用于改善哺乳动物细胞培养物中的蛋白质生产力。