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1.发明授权公开(公告)号：US09200069B2
公开(公告)日：2015-12-01
申请号：US14614311
申请日：2015-02-04
Applicant: AbbVie, Inc.
Inventor： Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
Abstract translation: 本发明涉及包含蛋白质例如抗体或其抗原结合部分的低酸性物质（AR）组合物，以及用于生产这种低AR组合物的方法，例如细胞培养和/或蛋白质纯化方法。 还提供了使用这种组合物治疗病症（例如其中TNFα有害的病症）的方法。
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公开(公告)号：US20150140006A1
公开(公告)日：2015-05-21
申请号：US14614311
申请日：2015-02-04
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US20150132320A1
公开(公告)日：2015-05-14
申请号：US14570489
申请日：2014-12-15
Applicant: AbbVie, Inc.
Inventor： Chris M. Chumsae , Zehra Kaymakcalan
IPC: C07K16/24
CPC classification number: C07K16/241 , C07K2317/40 , C07K2317/565 , C07K2317/94 , Y10S514/863
Abstract: The present invention is directed to modified antibodies, including anti-TNFα antibodies, in which C-terminal amino acids of heavy chain sequences are modified from a native sequence of proline-glycine-lysine (“PGK”) to one that includes a proline positioned between the glycine and lysine, resulting in a C-terminal sequence of proline-glycine-proline-lycine (“PGPK”). The invention further provides methods of producing and using such antibodies.
Abstract translation: 本发明涉及包含抗TNFα抗体的修饰抗体，其中重链序列的C末端氨基酸从脯氨酸 - 甘氨酸 - 赖氨酸天然序列（“PGK”）修饰为包含位于脯氨酸 - 甘氨酸 - 赖氨酸 在甘氨酸和赖氨酸之间产生脯氨酸 - 甘氨酸 - 脯氨酸 - 脯氨酸（“PGPK”）的C-末端序列。 本发明还提供了生产和使用这些抗体的方法。
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公开(公告)号：US20140271626A1
公开(公告)日：2014-09-18
申请号：US14206296
申请日：2014-03-12
Applicant: AbbVie Inc.
Inventor： Chris M. Chumsae , Zehra Kaymakcalan
IPC: C07K16/24
CPC classification number: C07K16/241 , C07K2317/40 , C07K2317/565 , C07K2317/94 , Y10S514/863
Abstract: The present invention is directed to modified antibodies, including anti-TNFα antibodies, in which C-terminal amino acids of heavy chain sequences are modified from a native sequence of proline-glycine-lysine (“PGK”) to one that includes a proline positioned between the glycine and lysine, resulting in a C-terminal sequence of proline-glycine-proline-lycine (“PGPK”). The invention further provides methods of producing and using such antibodies.
Abstract translation: 本发明涉及包含抗TNFα抗体的修饰抗体，其中重链序列的C末端氨基酸从脯氨酸 - 甘氨酸 - 赖氨酸天然序列（“PGK”）修饰为包含位于脯氨酸 - 甘氨酸 - 赖氨酸 在甘氨酸和赖氨酸之间产生脯氨酸 - 甘氨酸 - 脯氨酸 - 脯氨酸（“PGPK”）的C-末端序列。 本发明还提供了生产和使用这些抗体的方法。
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5.发明申请公开(公告)号：US20160237150A1
公开(公告)日：2016-08-18
申请号：US14923966
申请日：2015-10-27
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Mayda Perez Thiele , Xiaobei Zeng , Chee Furng Wong , Zehra Kaymakcalan , Ying Jing , Christopher M. Chumsae
CPC classification number: C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C12P21/005
Abstract: The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20150259410A1
公开(公告)日：2015-09-17
申请号：US14714113
申请日：2015-05-15
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
Abstract translation: 本发明涉及包含蛋白质例如抗体或其抗原结合部分的低酸性物质（AR）组合物，以及用于产生这种低AR组合物的方法，例如细胞培养和/或蛋白质纯化方法。 还提供了使用这种组合物治疗病症（例如其中TNFα有害的病症）的方法。
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7.发明授权公开(公告)号：US09085618B2
公开(公告)日：2015-07-21
申请号：US14077871
申请日：2013-11-12
Applicant: AbbVie, Inc.
Inventor： Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimxental, are also provided.
Abstract translation: 本发明涉及包含蛋白质例如抗体或其抗原结合部分的低酸性物质（AR）组合物，以及用于产生这种低AR组合物的方法，例如细胞培养和/或蛋白质纯化方法。 还提供了使用这些组合物治疗病症（例如其中TNFα是detricxental的病症）的方法。
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公开(公告)号：US20140155579A1
公开(公告)日：2014-06-05
申请号：US13900841
申请日：2013-05-23
Applicant: AbbVie Inc.
Inventor： Albert Collinson , George Avgerinos , Richard Dixon , Tariq Ghayur , Zehra Kaymakcalan
IPC: C07K16/24
CPC classification number: C07K16/245 , A61K47/6845 , A61K2039/505 , C07K14/545 , C07K16/46 , C07K16/468 , C07K2317/10 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , G01N33/6869
Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1α and IL-1β and neutralize IL-1α and IL-1β activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1α and IL-β) and for inhibiting the activity of the antigens, e.g., in a human subject suffering from a disorder in which IL-1α and/or IL-1β activity is detrimental.
Abstract translation: 提供了对两种不同但结构相关抗原具有双重特异性的抗体。 抗体可以是例如完全是人抗体，重组抗体或单克隆抗体。 优选的抗体对IL-1α和IL-1＆bgr具有双重特异性; 并中和IL-1α和IL-1和bgr; 体外和体内活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测两种不同但结构相关的抗原（例如，IL-1α和IL-和bgr），并且用于抑制抗原的活性，例如在患有 其中IL-1α和/或IL-1和bgr的病症 活动是有害的。
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公开(公告)号：US09315574B2
公开(公告)日：2016-04-19
申请号：US14584619
申请日：2014-12-29
Applicant: AbbVie, Inc.
Inventor： Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
IPC: C07K14/525 , A61K39/395 , C07K16/24 , C07K16/00 , A61K39/00
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US09522953B2
公开(公告)日：2016-12-20
申请号：US15009286
申请日：2016-01-28
Applicant: AbbVie, Inc.
Inventor： Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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