公开(公告)号：US20240225440A1

公开(公告)日：2024-07-11

申请号：US18615043

申请日：2024-03-25

申请人： ACUCELA INC.

发明人： Ryo KUBOTA ,  Stephan WYDER ,  Philip M. BUSCEMI ,  Matthias PFISTER ,  Cyril STOLLER

IPC分类号： A61B3/10 ,  G01B9/02091

CPC分类号： A61B3/102 ,  G01B9/02091

摘要： An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. Measurement data may be processed using a decurving process to enhance the resolution of the ILM layer and provide improved determinations of retinal thickness.

公开(公告)号：US20230273460A1

公开(公告)日：2023-08-31

申请号：US18314996

申请日：2023-05-10

申请人： ACUCELA INC.

发明人： Philip M. BUSCEMI ,  Ryo KUBOTA

IPC分类号： G02C7/04 ,  G02B27/01 ,  G02C7/14

CPC分类号： G02C7/04 ,  G02B27/017 ,  G02C7/14 ,  G02B2027/0178 ,  G02C2202/24

摘要： Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person’s eye. The stimulus or stimuli creates an image that is defocused in front of the person’s retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.

公开(公告)号：US20230210360A1

公开(公告)日：2023-07-06

申请号：US18177993

申请日：2023-03-03

申请人： ACUCELA INC.

发明人： Lukas SCHEIBLER ,  Matthias PFISTER ,  Urban SCHNELL ,  Stefan TROLLER ,  Ryo KUBOTA

IPC分类号： A61B3/10 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  G01B9/02

CPC分类号： A61B3/102 ,  A61B3/1005 ,  A61B3/0008 ,  A61B3/0025 ,  A61B3/1225 ,  A61B5/0013 ,  G01B9/02 ,  A61B3/10 ,  A61B2576/00 ,  A61B2560/0431 ,  A61B2505/07 ,  A61B2560/0425 ,  A61B2560/0456

摘要： Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US20220404641A1

公开(公告)日：2022-12-22

申请号：US17823208

申请日：2022-08-30

申请人： ACUCELA INC.

发明人： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Amitava GUPTA ,  Stefan BAUER ,  Benjamin CROOK ,  Julien SAUVET

IPC分类号： G02C7/08 ,  G02C7/06 ,  G02C7/14 ,  G02C7/10 ,  G02C7/02

摘要： An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

公开(公告)号：US20220390768A1

公开(公告)日：2022-12-08

申请号：US17821079

申请日：2022-08-19

申请人： ACUCELA INC.

发明人： Ryo KUBOTA ,  Amitava GUPTA

IPC分类号： G02C7/08 ,  G02F1/29

摘要： An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.

公开(公告)号：US20210382325A1

公开(公告)日：2021-12-09

申请号：US17304691

申请日：2021-06-24

申请人： ACUCELA INC.

发明人： Ryo KUBOTA ,  Nabin JOSHI ,  Arkady SELENOW ,  Steve ALI ,  Stefan BAUER ,  Jean-Noël FEHR ,  Moritz HAEBERLI ,  Patrizia WEBER ,  Julien SAUVET ,  Amitava GUPTA

IPC分类号： G02C7/06 ,  G02C11/04 ,  G02C7/02

摘要： An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10−1 to 2.5×101 cycles per degree.

公开(公告)号：US20180346407A1

公开(公告)日：2018-12-06

申请号：US15967080

申请日：2018-04-30

申请人： Acucela Inc.

发明人： Claes Olof BAVIK ,  Susan Hayes HENRY ,  Ryo KUBOTA ,  Vladimir A. KUKSA

IPC分类号： C07C215/08 ,  A61K31/765 ,  A61K31/35 ,  A61K31/137 ,  A61K45/06 ,  A61K31/138 ,  C07C323/32 ,  C07C217/20 ,  C07C211/27 ,  C07D309/06

摘要： Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.

公开(公告)号：US20230324717A1

公开(公告)日：2023-10-12

申请号：US18330010

申请日：2023-06-06

申请人： ACUCELA INC.

发明人： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Amitava GUPTA ,  Stefan BAUER ,  Benjamin CROOK ,  Julien SAUVET

IPC分类号： G02C7/08 ,  G02C7/06 ,  G02C7/14 ,  G02C7/10 ,  G02C7/02

CPC分类号： G02C7/08 ,  G02C7/06 ,  G02C7/14 ,  G02C7/10 ,  G02C7/022 ,  G02C2202/24

摘要： An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

公开(公告)号：US20230144121A1

公开(公告)日：2023-05-11

申请号：US18153000

申请日：2023-01-11

申请人： ACUCELA INC.

发明人： Ryo KUBOTA ,  Karim HAROUD ,  Beat WYSS ,  Hans BERNHARD ,  Jean-Noel FEHR ,  Patrizia WEBER ,  Moritz HAEBERLI ,  Amitava GUPTA

IPC分类号： A61N5/06 ,  G02B27/30 ,  G02B27/01

CPC分类号： A61N5/0622 ,  G02B27/30 ,  G02B27/0172 ,  A61N2005/063 ,  A61N2005/0648 ,  A61N2005/0652 ,  A61N2005/0663 ,  G02B2027/0178

摘要： A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

公开(公告)号：US20230063265A1

公开(公告)日：2023-03-02

申请号：US17904450

申请日：2021-02-19

申请人： ACUCELA INC.

发明人： Ryo KUBOTA ,  Patrizia WEBER ,  Marco BURGENER ,  Jonas BUTSCHER ,  Praveenth SANMUGARAJAH ,  Hans BERNHARD ,  Amitava GUPTA

IPC分类号： H02J50/10 ,  H02J50/40 ,  H02J7/00 ,  G02C7/04 ,  G02C11/00 ,  A45C11/00 ,  A45C15/00

摘要： A contact lens charging case comprises a container sized and shaped to receive an electronic contact lens (“eCL”) and charging coil to couple to a coil of the eCL. In some embodiments, the charging coil comprises a diameter larger than a diameter of the coil of the eCL, so as to decrease sensitivity of the location and orientation of the eCL in the container and improve coupling between the coils. In some embodiments, the charging coil is dimensioned so as to extend at least partially around the container that receives the eCL.