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公开(公告)号：US07501538B2
公开(公告)日：2009-03-10
申请号：US10913882
申请日：2004-08-06
申请人： Adnan M. M. Mjalli , Guoxiang Huang , Murty N. Arimilli , Thomas Scott Yokum , Jeff Jiqun Zhu , Muralidhar Bondlela
发明人： Adnan M. M. Mjalli , Guoxiang Huang , Murty N. Arimilli , Thomas Scott Yokum , Jeff Jiqun Zhu , Muralidhar Bondlela
IPC分类号： C07C229/00
CPC分类号： C07D295/155 , C07C233/87 , C07C235/42 , C07C235/52 , C07C235/60 , C07C235/66 , C07C237/36 , C07C237/42 , C07C271/20 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/44 , C07C317/32 , C07C323/36 , C07C2601/08
摘要： This invention provides aryl and heteroaryl compounds of Formula (I) as described herein, and methods of their preparation. Also provided are pharmaceutical compositions made with the compounds of Formula (I) and methods for making such compositions. The compounds of Formula (I) may activate an erythropoietin receptor and thus, may be useful to induce red blood cell production. The compounds of Formula (I) and compositions including compounds of Formula (I) may be useful in a variety of applications including the management, treatment and/or control of diseases caused at least in part by deficient (or inefficient) EPO production relative to hemoglobin level.
摘要翻译： 本发明提供了本文所述的式（I）的芳基和杂芳基化合物及其制备方法。 还提供了用式（I）的化合物制备的药物组合物和制备这些组合物的方法。 式（I）的化合物可以激活促红细胞生成素受体，因此可用于诱导红细胞生成。 式（I）化合物和包含式（I）化合物的组合物可用于各种应用，包括至少部分地由EPO生产缺陷（或低效）引起的疾病的管理，治疗和/或控制，相对于 血红蛋白水平。
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公开(公告)号：US07459472B2
公开(公告)日：2008-12-02
申请号：US10913216
申请日：2004-08-06
申请人： Adnan M. M. Mjalli , Robert C. Andrews , Murty N. Arimilli , Mohan Rao , Mustafa Guzel , Muralidhar Bondlela , Xiao-Chuan Guo , Guoxiang Huang
发明人： Adnan M. M. Mjalli , Robert C. Andrews , Murty N. Arimilli , Mohan Rao , Mustafa Guzel , Muralidhar Bondlela , Xiao-Chuan Guo , Guoxiang Huang
IPC分类号： A61K31/41 , C07D271/06
CPC分类号： C07D295/155 , C07C233/87 , C07C235/42 , C07C235/52 , C07C235/60 , C07C235/66 , C07C237/36 , C07C237/42 , C07C271/20 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/44 , C07C317/32 , C07C323/36 , C07C2601/08
摘要： This invention provides aryl and heteroaryl compounds of Formula (I) as described herein, and methods of their preparation. Also provided are pharmaceutical compositions made with the compounds of Formula (I) and methods for making such compositions. Compounds of Formula (I) may be useful for treating viral infections including orthopox viruses, either alone or in combination with other therapeutic agents.
摘要翻译： 本发明提供了本文所述的式（I）的芳基和杂芳基化合物及其制备方法。 还提供了用式（I）的化合物制备的药物组合物和制备这些组合物的方法。 式（I）的化合物可用于单独或与其它治疗剂组合治疗包括正痘病毒的病毒感染。
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3.发明授权公开(公告)号：US08383644B2
公开(公告)日：2013-02-26
申请号：US12825631
申请日：2010-06-29
申请人： Adnan M. M. Mjalli , Christopher Behme , Daniel P. Christen , Devi Reddy Gohimukkula , Dharma Rao Polisetti , James Quada , Jennifer L. R. Freeman , Kalpathy Santhosh , Muralidhar Bondlela , Mustafa Guzel , Ravindra Reddy Yarragunta , Robert Carl Andrews , Stephen Thomas Davis , Thomas Scott Yokum
发明人： Adnan M. M. Mjalli , Christopher Behme , Daniel P. Christen , Devi Reddy Gohimukkula , Dharma Rao Polisetti , James Quada , Jennifer L. R. Freeman , Kalpathy Santhosh , Muralidhar Bondlela , Mustafa Guzel , Ravindra Reddy Yarragunta , Robert Carl Andrews , Stephen Thomas Davis , Thomas Scott Yokum
IPC分类号： C07D491/056 , A61K31/436
CPC分类号： C07D491/056 , C07D319/20 , C07D491/06
摘要： The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.
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4.发明授权Bissulfonamide compounds as agonists of GalR1, compositions, and methods of use 失效作为GalR1的激动剂的双磺酰胺化合物，组合物和使用方法公开(公告)号：US07582673B2
公开(公告)日：2009-09-01
申请号：US11255000
申请日：2005-10-20
申请人： Adnan M. M. Mjalli , Bapu Gaddam , Mohan Rao , Muralidhar Bondlela , Ramesh Gopalaswamy , Robert C. Andrews , Stephen Davis , Suvi Simila , Tan Ren
发明人： Adnan M. M. Mjalli , Bapu Gaddam , Mohan Rao , Muralidhar Bondlela , Ramesh Gopalaswamy , Robert C. Andrews , Stephen Davis , Suvi Simila , Tan Ren
IPC分类号： A61K31/381 , A61K31/18 , C07D333/66 , C07C311/21
CPC分类号： C07D213/42 , C07C311/29 , C07D233/54 , C07D307/82 , C07D333/34 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/12 , C07D495/04
摘要： Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are agonists of GalR1, and methods of use of such compounds and compositions.
摘要翻译： 本发明的实施方案提供作为GalR1的激动剂的双磺酰胺化合物。 本发明还提供了包含作为GalR1的激动剂的双磺酰胺化合物的组合物，以及这些化合物和组合物的使用方法。
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5.发明申请SUBSTITUTED AZOANTHRACENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 有权取代的十八烷基衍生物，药物组合物及其使用方法公开(公告)号：US20110160198A1
公开(公告)日：2011-06-30
申请号：US12825631
申请日：2010-06-29
申请人： Adnan M.M. Mjalli , Christopher Behme , Daniel P. Christen , Devi Reddy Gohimukkula , Dharma Rao Polisetti , James Quada , Jennifer L.R. Freeman , Kalpathy Santhosh , Muralidhar Bondlela , Mustafa Guzel , Ravindra Reddy Yarragunta , Robert Carl Andrews , Stephen Thomas Davis , Thomas Scott Yokum
发明人： Adnan M.M. Mjalli , Christopher Behme , Daniel P. Christen , Devi Reddy Gohimukkula , Dharma Rao Polisetti , James Quada , Jennifer L.R. Freeman , Kalpathy Santhosh , Muralidhar Bondlela , Mustafa Guzel , Ravindra Reddy Yarragunta , Robert Carl Andrews , Stephen Thomas Davis , Thomas Scott Yokum
IPC分类号： A61K31/4741 , C07D491/056 , C07D498/04 , A61K31/497 , A61K31/5383 , A61K31/5377 , A61P3/00 , A61P3/06 , A61P3/10 , A61P3/04 , A61P9/10 , A61P9/12
CPC分类号： C07D491/056 , C07D319/20 , C07D491/06
摘要： The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.
摘要翻译： 本发明涉及调节人GLP-1受体并且可用于治疗人GLP-1受体调节有益的疾病，病症或病症的取代的偶氮蒽衍生物或其药学上可接受的盐， 例如2型糖尿病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗人GLP-1受体调节有益的疾病，病症或病症中的用途 。
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公开(公告)号：US20100036150A1
公开(公告)日：2010-02-11
申请号：US12446775
申请日：2007-10-24
申请人： Dharma Rao Polisetti , Daniel P. Christen , Mustafa Guzel , Thomas Scott Yokum , Muralidhar Bondlela
发明人： Dharma Rao Polisetti , Daniel P. Christen , Mustafa Guzel , Thomas Scott Yokum , Muralidhar Bondlela
CPC分类号： C07C69/734 , C12P7/42 , C12P41/004
摘要： The invention relates to compounds, compositions, methods of using and processes for producing optically active α-hydroxy derivatives using a combination of a chemical and biochemical methods. The process comprises reacting an ester compound with a racemic compound in the presence of an enzyme to obtain compounds (compositions and methods). The compounds produced may be useful for starting materials for physiologically active materials, functional materials and the like.
摘要翻译： 本发明涉及使用化学和生物化学方法的组合的化合物，组合物，使用方法和制备光学活性α-羟基衍生物的方法。 该方法包括在酶的存在下使酯化合物与外消旋化合物反应以获得化合物（组合物和方法）。 制备的化合物可用于生理活性材料，功能材料等的起始材料。
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公开(公告)号：US20050059713A1
公开(公告)日：2005-03-17
申请号：US10913216
申请日：2004-08-06
申请人： Adnan Mjalli , Robert Andrews , Murty Arimilli , Mohan Rao , Mustafa Guzel , Muralidhar Bondlela , Xiao-Chuan Guo , Guoxiang Huang
发明人： Adnan Mjalli , Robert Andrews , Murty Arimilli , Mohan Rao , Mustafa Guzel , Muralidhar Bondlela , Xiao-Chuan Guo , Guoxiang Huang
IPC分类号： A61P31/12 , C07C233/87 , C07C235/42 , C07C235/52 , C07C235/60 , C07C235/66 , C07C237/36 , C07C237/42 , C07C271/20 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/44 , C07C317/32 , C07C323/36 , C07D295/155 , C07D213/55 , A61K31/155 , A61K31/195 , A61K31/44
CPC分类号： C07D295/155 , C07C233/87 , C07C235/42 , C07C235/52 , C07C235/60 , C07C235/66 , C07C237/36 , C07C237/42 , C07C271/20 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/44 , C07C317/32 , C07C323/36 , C07C2601/08
摘要： This invention provides aryl and heteroaryl compounds of Formula (I) as described herein, and methods of their preparation. Also provided are pharmaceutical compositions made with the compounds of Formula (I) and methods for making such compositions. Compounds of Formula (I) may be useful for treating viral infections including orthopox viruses, either alone or in combination with other therapeutic agents.
摘要翻译： 本发明提供了本文所述的式（I）的芳基和杂芳基化合物及其制备方法。 还提供了用式（I）的化合物制备的药物组合物和制备这些组合物的方法。 式（I）的化合物可用于单独或与其它治疗剂组合治疗包括正痘病毒的病毒感染。
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公开(公告)号：US20110230458A1
公开(公告)日：2011-09-22
申请号：US13028036
申请日：2011-02-15
申请人： Devi R. Gohimukkula , David Jones , Ghassan Qabaja , Jeff J. Zhu , Jeremy T. Cooper , William K. Banner , Kurt Sundermann , Muralidhar Bondlela , Mohan Rao , Pingzhen Wang , Raju B. Gowda , Robert C. Andrews , Suparna Gupta , Anitha Hari
发明人： Devi R. Gohimukkula , David Jones , Ghassan Qabaja , Jeff J. Zhu , Jeremy T. Cooper , William K. Banner , Kurt Sundermann , Muralidhar Bondlela , Mohan Rao , Pingzhen Wang , Raju B. Gowda , Robert C. Andrews , Suparna Gupta , Anitha Hari
IPC分类号： A61K31/397 , C07D401/12 , A61K31/501 , C07D413/12 , A61K31/5377 , C07D401/14 , C07D413/14 , A61P29/00 , A61P17/00 , A61P11/00 , A61P3/10 , A61P13/12 , A61P9/00 , A61P25/00 , A61P15/10 , A61P19/10 , A61P35/04
CPC分类号： C07D401/12 , A61K31/497 , C07D237/14 , C07D237/24 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D471/04
摘要： The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereof These compounds are useful in the treatment of RAGE-mediated diseases such as Alzheimer's Disease.The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.
摘要翻译： 本发明提供式（I）的苯基 - 杂芳基衍生物及其药学上可接受的盐。这些化合物可用于治疗RAGE介导的疾病如阿尔茨海默氏病。 本发明还涉及制备式（I）的化合物及其药学上可接受的盐，包含这些化合物的药物组合物的方法，以及这些化合物和/或药物组合物在治疗RAGE介导的疾病中的用途。
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9.发明申请Bissulfonamide Compounds As Agonists Of GalR1, Compositions, And Methods Of Use 审中-公开双磺酰胺化合物作为GalR1的激动剂，组合物和使用方法公开(公告)号：US20090247536A1
公开(公告)日：2009-10-01
申请号：US12483429
申请日：2009-06-12
申请人： Adnan M.M. Mjalli , Bapu Gaddam , Mohan Rao , Muralidhar Bondlela , Ramesh Gopalaswamy , Robert C. Andrews , Stephen Davis , Suvi Simila , Tan Ren
发明人： Adnan M.M. Mjalli , Bapu Gaddam , Mohan Rao , Muralidhar Bondlela , Ramesh Gopalaswamy , Robert C. Andrews , Stephen Davis , Suvi Simila , Tan Ren
IPC分类号： A61K31/497 , A61K31/381 , A61K31/4164 , A61P25/00
CPC分类号： C07D213/42 , C07C311/29 , C07D233/54 , C07D307/82 , C07D333/34 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/12 , C07D495/04
摘要： Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are agonists of GalR1, and methods of use of such compounds and compositions.
摘要翻译： 本发明的实施方案提供作为GalR1的激动剂的双磺酰胺化合物。 本发明还提供了包含作为GalR1的激动剂的双磺酰胺化合物的组合物，以及这些化合物和组合物的使用方法。
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公开(公告)号：US20060106089A1
公开(公告)日：2006-05-18
申请号：US11255000
申请日：2005-10-20
申请人： Adnan Mjalli , Bapu Gaddam , Mohan Rao , Muralidhar Bondlela , Ramesh Gopalaswamy , Robert Andrews , Stephen Davis , Suvi Simila , Tan Ren
发明人： Adnan Mjalli , Bapu Gaddam , Mohan Rao , Muralidhar Bondlela , Ramesh Gopalaswamy , Robert Andrews , Stephen Davis , Suvi Simila , Tan Ren
IPC分类号： A61K31/381 , C07D409/02 , A61K31/18 , C07C311/37
CPC分类号： C07D213/42 , C07C311/29 , C07D233/54 , C07D307/82 , C07D333/34 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/12 , C07D495/04
摘要： Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are agonists of GalR1, and methods of use of such compounds and compositions.
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