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1.发明授权公开(公告)号：US10604561B2
公开(公告)日：2020-03-31
申请号：US16333736
申请日：2017-09-15
Inventor： Zenjiro Sampei , Xing'er Christine Koo , Katja Fink , Roland Zuest
IPC: A61K39/00 , A61K39/12 , A61K39/295 , C07K14/005 , C07K16/10 , A61P31/12
Abstract: The disclosure provides anti-DENV antibodies and methods of making and using the same. Nucleic acids encoding anti-DENV antibodies and host cells comprising the nucleic acids are also provided. The anti-DENV antibodies have uses that include treating DENV infection. The disclosure also provided polypeptides containing a variant Fc region and methods of making the same. Nucleic acids encoding polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include treating a viral infection. Also claimed is a polypeptide comprising a Fc variant comprising at least one amino acid alteration in a parent Fc region, wherein the variant Fc region has a substantially decreased FcYR-binding activity and does not have a substantially decreased C1 q-binding activity when compared to the parent Fc region.
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2.发明授权公开(公告)号：US11780908B2
公开(公告)日：2023-10-10
申请号：US17066092
申请日：2020-10-08
Inventor： Zenjiro Sampei , Xing'er Christine Koo , Katja Fink , Roland Zuest
CPC classification number: C07K16/1081 , A61P31/12 , A61K2039/505 , C07K2317/52 , C07K2317/56 , C07K2317/734 , C07K2317/92 , C07K2317/94 , Y02A50/30
Abstract: The disclosure provides anti-DENV antibodies and methods of making and using the same. Nucleic acids encoding anti-DENV antibodies and host cells comprising the nucleic acids are also provided. The anti-DENV antibodies have uses that include treating DENV infection. The disclosure also provided polypeptides containing a variant Fc region and methods of making the same. Nucleic acids encoding polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include treating a viral infection. Also claimed is a polypeptide comprising a Fc variant comprising at least one amino acid alteration in a parent Fc region, wherein the variant Fc region has a substantially decreased FcYR-binding activity and does not have a substantially decreased C1 q-binding activity when compared to the parent Fc region.
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公开(公告)号：US20150231226A1
公开(公告)日：2015-08-20
申请号：US14430099
申请日：2013-09-23
Applicant: Agency for Science, Technology and Research , Novartis AG , Beijing Institute of Microbiology and Epidemiology
Inventor： Katja Fink , Pei-Yong Shi , Cheng Feng Qin
CPC classification number: A61K39/12 , A61K2039/5252 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , Y02A50/386
Abstract: The present invention discloses a method of eliciting an immune response and a method of vaccination comprising administration of a mutated flavivirus. The mutated flavivirus comprises at least one mutation in a nucleic acid sequence encoding for the non-structural protein 5 of the flavivirus sequence resulting in inactivation of the 2′O-methyltransferase.
Abstract translation: 本发明公开了引发免疫应答的方法和一种疫苗接种方法，包括施用突变的黄病毒。 突变的黄病毒包括编码黄病毒序列的非结构蛋白5的核酸序列中的至少一个突变，导致2'O-甲基转移酶的失活。
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Patent Agency Ranking
4.发明授权公开(公告)号：US12187786B2
公开(公告)日：2025-01-07
申请号：US18453418
申请日：2023-08-22
Inventor： Zenjiro Sampei , Xing'er Christine Koo , Katja Fink , Roland Zuest
IPC: C07K16/10 , A61K39/12 , A61K39/395 , A61P31/12 , C07K14/005 , C07K16/00 , A61K39/00
Abstract: The disclosure provides anti-DENV antibodies and methods of making and using the same. Nucleic acids encoding the anti-DENV antibodies and host cells comprising the nucleic acids are also provided. The anti-DENV antibodies have uses that include treating DENV infection. The disclosure also provided polypeptides containing a variant Fc region and methods of making and using the same. Nucleic acids encoding the polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include treating a viral infection. Also claimed is a polypeptide comprising a Fc variant comprising at least one amino acid alteration in a parent Fc region, wherein the variant Fc region has a substantially decreased FcYR-binding activity and does not have a substantially decreased C1 q-binding activity when compared to the parent Fc region.
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公开(公告)号：US20210000856A1
公开(公告)日：2021-01-07
申请号：US16960634
申请日：2019-01-17
Inventor： Dahai Luo , Katja Fink , Hui Yee Yong , Chin Yong Victor Ho
IPC: A61K31/713 , C12N15/117
Abstract: The present invention generally relates to specific immune-modulatory RNA species that have a small hairpin structure (shRNA), and that can bind to retinoic acid inducible gene I receptor (RIG-I). In particular, said RNA species comprise a nucleotide insertion to create a kink in the stem region. Also encompassed are compositions comprising such shRNA, for use as antiviral or anticancer medication, or as adjuvants in vaccine.
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公开(公告)号：US11499157B2
公开(公告)日：2022-11-15
申请号：US16960634
申请日：2019-01-17
Inventor： Dahai Luo , Katja Fink , Hui Yee Yong , Chin Yong Victor Ho
IPC: C07H21/04 , C12N15/117 , A61K31/713 , C12N15/113 , A61K45/06
Abstract: The present invention generally relates to specific immune-modulatory RNA species that have a small hairpin structure (shRNA), and that can bind to retinoic acid inducible gene I receptor (RIG-I). In particular, said RNA species comprise a nucleotide insertion to create a kink in the stem region. Also encompassed are compositions comprising such shRNA, for use as antiviral or anticancer medication, or as adjuvants in vaccine.
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公开(公告)号：US10316078B2
公开(公告)日：2019-06-11
申请号：US15558937
申请日：2016-03-17
Inventor： Cheng-I Wang , Katja Fink , Paul Macary , Roland Zuest , Meihui Xu
IPC: C07K16/10 , G01N33/569 , A61P31/12 , A61K39/00
Abstract: Disclosed are isolated antibodies, or antigen binding fragments thereof, that bind to dengue virus epitopes, as well as kits containing them, compositions containing them, and passive vaccines comprising them, in one embodiment, the antibody or antigen binding fragment thereof is capable of binding to a whole dengue virus particle better than binding to a dengue virus surface glycoprotein. Also disclosed are methods of using the antibodies or antigen binding fragments thereof, nucleic acids encoding them, vectors expressing the nucleic acids, host producing them, and methods of manufacturing them.
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公开(公告)号：US20140349321A1
公开(公告)日：2014-11-27
申请号：US14365853
申请日：2012-12-17
Applicant: Agency for Science, Technology and Research
Inventor： Katja Fink , Cheng-I Wang
IPC: C07K16/10 , G01N33/543
CPC classification number: C07K16/1081 , C07K2317/10 , C07K2317/31 , C07K2317/33 , C07K2317/76 , G01N33/54306 , G01N2333/47
Abstract: The present invention relates to binding molecules suited to the diagnosis, prevention and/or treatment of dengue virus infection.
Abstract translation: 本发明涉及适合于登革热病毒感染的诊断，预防和/或治疗的结合分子。
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