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公开(公告)号：US11634503B2
公开(公告)日：2023-04-25
申请号：US16866408
申请日：2020-05-04
申请人： AGENSYS, INC. , SEAGEN INC.
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US10669348B2
公开(公告)日：2020-06-02
申请号：US15895996
申请日：2018-02-13
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US09962454B2
公开(公告)日：2018-05-08
申请号：US15069853
申请日：2016-03-14
发明人： Daulet Satpayev , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
IPC分类号： C07K16/18 , C12P21/08 , A61K39/395 , A61K47/48 , C07K16/30 , A61N5/10 , A61K47/68 , A61K39/00
CPC分类号： A61K47/6851 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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4.发明授权Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers 有权核酸和相应的名为158P1D7的蛋白质可用于膀胱癌和其他癌症的治疗和检测公开(公告)号：US08945570B2
公开(公告)日：2015-02-03
申请号：US13662318
申请日：2012-10-26
申请人： Agensys, Inc.
发明人： Aya Jakobovits , Robert Kendall Morrison , Arthur B. Raitano , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen Jane Meyrick Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven B. Kanner
IPC分类号： A61K31/00 , A61K35/14 , A61K38/00 , A61K38/16 , A61K39/00 , A61K39/395 , A61K49/00 , A61B5/055 , A01N61/00 , C07K1/00 , C07K14/00 , C07K16/00 , C07K16/30 , C07K14/47 , A61K47/48 , A61K51/10
CPC分类号： C07K16/18 , A61K38/00 , A61K47/646 , A61K47/6813 , A61K51/1093 , C07K14/47 , C07K16/30 , C07K16/3038 , C07K2317/54 , C07K2317/55 , C07K2317/622 , G01N33/57484 , Y10T436/25
摘要： The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express 158P1D7 and variants thereof.
摘要翻译： 本文描述的本发明涉及新颖的核酸序列及其编码的蛋白质，被称为158P1D7及其变体，以及可用于治疗表达158P1D7及其变体的各种癌症的诊断和治疗方法和组合物。
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公开(公告)号：US20140051096A9
公开(公告)日：2014-02-20
申请号：US13662332
申请日：2012-10-26
申请人： AGENSYS, INC.
发明人： Aya JAKOBOVITS , Robert Kendall Morrison , Arthur B. Raitano , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen Jane Meyrick Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven B. Kanner
IPC分类号： G01N33/574 , G01N33/577 , G01N33/566
CPC分类号： C07K16/18 , A61K38/00 , A61K47/646 , A61K47/6813 , A61K51/1093 , C07K14/47 , C07K16/30 , C07K16/3038 , C07K2317/54 , C07K2317/55 , C07K2317/622 , G01N33/57484 , Y10T436/25
摘要： The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express 158P1D7 and variants thereof.
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公开(公告)号：US11292837B2
公开(公告)日：2022-04-05
申请号：US16619439
申请日：2018-06-04
申请人： AGENSYS, INC.
IPC分类号： C07K16/28 , G01N33/574
摘要： Provided herein are compositions, methods and uses involving antibodies that specifically bind to Nectin-4. Also provided herein are methods for assessing Nectin-4 expression in a sample or a patient and methods for assessing responsiveness of a cancer patient to an anti-cancer therapeutic agent.
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公开(公告)号：US10894090B2
公开(公告)日：2021-01-19
申请号：US15943527
申请日：2018-04-02
申请人： AGENSYS, INC. , SEAGEN INC.
发明人： Daulet Satpayev , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
IPC分类号： A61K39/395 , A61K47/68 , C07K16/30 , A61K39/00
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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8.发明授权Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer 有权核酸和相应的标题为161P2F10B的蛋白质可用于治疗和检测癌症公开(公告)号：US08846043B2
公开(公告)日：2014-09-30
申请号：US14059374
申请日：2013-10-21
申请人： Agensys, Inc.
发明人： Aya Jakobovits , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Wangmao Ge , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Pia M. Challita-Eid
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K16/40 , C07K2317/20 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2319/30 , C12N9/16 , C12Q1/6886 , C12Q2600/158 , G01N33/57492 , Y02A50/466
摘要： A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 描述了新颖的基因0161P2F10B（也称为161P2F10B）及其编码的蛋白质及其变体，其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，161P2F10B提供了诊断， 癌症的预后，预防和/或治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US10787517B2
公开(公告)日：2020-09-29
申请号：US15572739
申请日：2016-05-18
申请人： AGENSYS, INC.
摘要： Antibodies that bind to AXL protein and variants thereof are described herein. AXL exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the MAbs of the invention provide a diagnostic composition for the treatment and management of cancer.
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公开(公告)号：USRE47103E1
公开(公告)日：2018-10-30
申请号：US15448507
申请日：2017-03-02
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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