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公开(公告)号：US09972480B2
公开(公告)日：2018-05-15
申请号：US14952012
申请日：2015-11-25
发明人： Trygve Ristroph
IPC分类号： H01J49/06
CPC分类号： H01J49/063 , H01J49/062
摘要： An ion guide generates a radio frequency (RF) field to radially confine ions to an ion beam along a guide axis as the ions are transmitted through the ion guide. The effective potential of the RF field includes an alternating series of barriers and wells. Ions may be trapped in individual wells in mass-dependent order, with larger masses trapped closer to a guide exit than smaller masses. The RF field may be scanned so as to release the ions from the ion guide in mass-dependent order, with larger masses released before smaller masses. The operating conditions may be set such that ions over the entire mass range arrive at a desired downstream focal point simultaneously, for example at an accelerator of a time-of-flight analyzer.
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公开(公告)号：US09627190B2
公开(公告)日：2017-04-18
申请号：US14671521
申请日：2015-03-27
发明人： Julia Zaks , Trygve Ristroph
CPC分类号： H01J49/401 , H01J49/0027 , H01J49/06
摘要： A time-of-flight mass spectrometer (TOF-MS) utilizes an ion dispersion device and a position-sensitive ion detector or an energy-sensitive ion detector to enable measurement of time of flight and kinetic energy of ions arriving at the detector. The measurements may be utilized to improve accuracy in calculating ion masses.
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公开(公告)号：US20160284531A1
公开(公告)日：2016-09-29
申请号：US14671521
申请日：2015-03-27
发明人： Julia Zaks , Trygve Ristroph
CPC分类号： H01J49/401 , H01J49/0027 , H01J49/06
摘要： A time-of-flight mass spectrometer (TOF-MS) utilizes an ion dispersion device and a position-sensitive ion detector or an energy-sensitive ion detector to enable measurement of time of flight and kinetic energy of ions arriving at the detector. The measurements may be utilized to improve accuracy in calculating ion masses.
摘要翻译： 飞行时间质谱仪（TOF-MS）使用离子分散装置和位置敏感离子检测器或能量敏感离子检测器来测量到达检测器的离子的飞行时间和动能。 可以使用测量来提高计算离子质量的精度。
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公开(公告)号：US20160225602A1
公开(公告)日：2016-08-04
申请号：US14959795
申请日：2015-12-04
发明人： Trygve Ristroph , Julia Zaks
IPC分类号： H01J49/40
CPC分类号： H01J49/40 , H01J49/009
摘要： A time-of-flight mass spectrometer (TOF-MS) utilizes a multi-channel ion detector to detect ions traveling in separate flight paths, spatially dispersed along a drift axis and/or a transverse axis, in a flight tube of a TOF analyzer. The ion beams may be dispersed by drift energy, deflection along the drift and/or transverse axis, ion mass, or a combination of two or more of the foregoing. The dispersion may be carried out before, at, or after an ion accelerator of the TOF analyzer. Ion packets may be accelerated into the flight tube at a multi-pulse firing rate. Tandem MS may be implemented on parallel ion beams simultaneously.
摘要翻译： 飞行时间质谱仪（TOF-MS）利用多通道离子检测器来检测在TOF分析仪的飞行管中沿着漂移轴和/或横向轴线分散的分开的飞行路径中的离子行进 。 离子束可以通过漂移能量分散，沿着漂移和/或横向轴线的偏转，离子质量或上述两种或更多种的组合。 分散体可以在TOF分析仪的离子加速剂之前，之中或之后进行。 离子包可以以多脉冲发射速率加速到飞行管中。 串联MS可以同时在并行离子束上实现。
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5.发明授权Plasma-based electron capture dissociation (ECD) apparatus and related systems and methods 有权基于等离子体的电子捕获解离（ECD）装置及相关系统和方法公开(公告)号：US09105454B2
公开(公告)日：2015-08-11
申请号：US14483462
申请日：2014-09-11
CPC分类号： H01J49/0054 , H05H1/24 , H05H1/2406 , H05H2001/4645 , H05H2001/481
摘要： An electron capture dissociation (ECD) apparatus includes a plasma source for generating plasma. Analyte ions are exposed to the plasma in an ECD interaction region, either inside or outside the plasma source. The apparatus may include one or more devices for refining the plasma in preparation for interaction with the analyte ions. Refining may entail removing unwanted species from the plasma, such as photons, metastable particles, neutral particles, and/or high-energy electrons unsuitable for ECD, and/or controlling a density of low-energy electrons in the plasma.
摘要翻译： 电子捕获离解（ECD）装置包括用于产生等离子体的等离子体源。 分析离子在等离子体源的内部或外部的ECD相互作用区域中暴露于等离子体。 该装置可以包括用于精制等离子体以准备与分析物离子相互作用的一个或多个装置。 精炼可能需要从等离子体中除去不想要的物质，例如不适合于ECD的光子，亚稳颗粒，中性粒子和/或高能电子，和/或控制等离子体中低能电子的密度。
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公开(公告)号：US09905410B2
公开(公告)日：2018-02-27
申请号：US14959795
申请日：2015-12-04
发明人： Trygve Ristroph , Julia Zaks
CPC分类号： H01J49/40 , H01J49/009
摘要： A time-of-flight mass spectrometer (TOF-MS) utilizes a multi-channel ion detector to detect ions traveling in separate flight paths, spatially dispersed along a drift axis and/or a transverse axis, in a flight tube of a TOF analyzer. The ion beams may be dispersed by drift energy, deflection along the drift and/or transverse axis, ion mass, or a combination of two or more of the foregoing. The dispersion may be carried out before, at, or after an ion accelerator of the TOF analyzer. Ion packets may be accelerated into the flight tube at a multi-pulse firing rate. Tandem MS may be implemented on parallel ion beams simultaneously.
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公开(公告)号：US20160225598A1
公开(公告)日：2016-08-04
申请号：US14952012
申请日：2015-11-25
发明人： Trygve Ristroph
CPC分类号： H01J49/063 , H01J49/062
摘要： An ion guide generates a radio frequency (RF) field to radially confine ions to an ion beam along a guide axis as the ions are transmitted through the ion guide. The effective potential of the RF field includes an alternating series of barriers and wells. Ions may be trapped in individual wells in mass-dependent order, with larger masses trapped closer to a guide exit than smaller masses. The RF field may be scanned so as to release the ions from the ion guide in mass-dependent order, with larger masses released before smaller masses. The operating conditions may be set such that ions over the entire mass range arrive at a desired downstream focal point simultaneously, for example at an accelerator of a time-of-flight analyzer.
摘要翻译： 当离子传输通过离子导向器时，离子导向器产生射频（RF）场以沿离心导向轴径向限制离子到离子束。 RF场的有效潜力包括交替的一系列屏障和井。 离子可能以质量依赖的顺序被困在各个井中，较大的质量较大的质量被困在导向出口附近。 可以扫描RF场，以便以质量相关的顺序从离子导向器释放离子，在较小的质量之前释放较大的质量。 操作条件可以被设置为使得整个质量范围上的离子同时到达期望的下游焦点，例如在飞行时间分析仪的加速器处。
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8.发明授权Radio frequency (RF) ion guide for improved performance in mass spectrometers at high pressure 有权射频（RF）离子导向器，用于在高压下改善质谱仪的性能公开(公告)号：US09053915B2
公开(公告)日：2015-06-09
申请号：US13626698
申请日：2012-09-25
发明人： Trygve Ristroph , Gershon Perelman
IPC分类号： H01J49/06
CPC分类号： H01J49/065 , H01J49/062 , H01J49/066 , H01J49/067
摘要： Ion guides for use in mass spectrometry (MS) systems are described. The ion guides are configured to provide a reflective electrodynamic field and a direct current (DC or static) electric field to provide ion beams that are more spatially confined with a comparatively large mass range. Some ion guides are provided between the ion source and the first stage vacuum chamber of the MS system.
摘要翻译： 描述了用于质谱（MS）系统的离子导向器。 离子导向器被配置为提供反射电动力场和直流（DC或静态）电场，以提供在空间上被限制在较大质量范围内的离子束。 在离子源和MS系统的第一级真空室之间提供一些离子导向器。
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9.发明申请PLASMA-BASED ELECTRON CAPTURE DISSOCIATION (ECD) APPARATUS AND RELATED SYSTEMS AND METHODS 有权基于等离子体的电子捕获解决（ECD）设备及相关系统和方法公开(公告)号：US20150122985A1
公开(公告)日：2015-05-07
申请号：US14483462
申请日：2014-09-11
CPC分类号： H01J49/0054 , H05H1/24 , H05H1/2406 , H05H2001/4645 , H05H2001/481
摘要： An electron capture dissociation (ECD) apparatus includes a plasma source for generating plasma. Analyte ions are exposed to the plasma in an ECD interaction region, either inside or outside the plasma source. The apparatus may include one or more devices for refining the plasma in preparation for interaction with the analyte ions. Refining may entail removing unwanted species from the plasma, such as photons, metastable particles, neutral particles, and/or high-energy electrons unsuitable for ECD, and/or controlling a density of low-energy electrons in the plasma.
摘要翻译： 电子捕获离解（ECD）装置包括用于产生等离子体的等离子体源。 分析物离子在等离子体源的内部或外部的ECD相互作用区域中暴露于等离子体。 该装置可以包括用于精制等离子体以准备与分析物离子相互作用的一个或多个装置。 精炼可能需要从等离子体中除去不需要的物质，例如不适合于ECD的光子，亚稳颗粒，中性粒子和/或高能电子，和/或控制等离子体中低能电子的密度。
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