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1.发明申请6-Amino-Pyrimidine-4-Carboxamide Derivatives and Related Compounds Which Bind to the Sphingosine 1-Phosphate (S1P) Receptor for the Treatment of Multiple Sclerosis 有权6-氨基 - 嘧啶-4-羧酰胺衍生物及其与1-磷酸鞘氨醇受体（S1P）接合治疗多发性硬化症的相关化合物公开(公告)号：US20100210619A1
公开(公告)日：2010-08-19
申请号：US12671996
申请日：2008-07-29
IPC分类号： A61K31/397 , C07D239/42 , A61K31/505 , C07D403/12 , A61K31/496 , C07D413/12 , A61K31/5377 , A61P3/10 , A61P19/02 , A61P17/06 , A61P11/06 , A61P1/00
CPC分类号： C07D239/42 , C07D401/12 , C07D403/12 , C07D413/12
摘要： The invention relates to compounds of formula (I): wherein X, W, Q, R, R1 and R2 have the meanings given in claim 15. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
摘要翻译： 本发明涉及式（I）的化合物：其中X，W，Q，R，R 1和R 2具有权利要求15中给出的含义。 治疗自身免疫性疾病，如多发性硬化症。
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2.发明授权6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis 有权6-氨基 - 嘧啶-4-甲酰胺衍生物和与鞘氨醇1-磷酸（S1P）受体结合以治疗多发性硬化症的相关化合物公开(公告)号：US08399448B2
公开(公告)日：2013-03-19
申请号：US12671996
申请日：2008-07-29
IPC分类号： A61K31/33 , A61K31/497 , A61K31/535 , C07D239/24 , C07D401/12 , C07D403/12 , C07D413/12
CPC分类号： C07D239/42 , C07D401/12 , C07D403/12 , C07D413/12
摘要： The invention relates to compounds of formula (I): wherein X, W, Q, R, R1 and R2 have the meanings given in claim 1. The compounds are useful, for example, in the treatment of autoimmune disorders, such as multiple sclerosis.
摘要翻译： 本发明涉及式（I）的化合物：其中X，W，Q，R，R 1和R 2具有权利要求1中给出的含义。该化合物可用于例如治疗自身免疫性疾病如多发性硬化 。
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公开(公告)号：US08202865B2
公开(公告)日：2012-06-19
申请号：US12675235
申请日：2008-10-01
申请人： Anna Quattropani , Cyril Montagne , Wolfgang Sauer , Stefano Crosignani , Agnes Bombrun , Mathilde Muzerelle , Jermone Dorbais , Delphine Marin , Jerome Gonzalez , Patrick Gerber
发明人： Anna Quattropani , Cyril Montagne , Wolfgang Sauer , Stefano Crosignani , Agnes Bombrun , Mathilde Muzerelle , Jermone Dorbais , Delphine Marin , Jerome Gonzalez , Patrick Gerber
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4439 , A61K31/4245 , C07D413/02 , C07D271/06
CPC分类号： C07D263/32 , C07D413/04 , C07D413/10
摘要： The invention relates to compounds of formula I: wherein R1, R2, Ra, Rb, W, Q and S have the meanings given in claim 16. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
摘要翻译： 本发明涉及式I化合物：其中R1，R2，Ra，Rb，W，Q和S具有权利要求16中给出的含义。 治疗自身免疫性疾病，如多发性硬化症。
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公开(公告)号：US20100240658A1
公开(公告)日：2010-09-23
申请号：US12675235
申请日：2008-10-01
申请人： Anna Quattropani , Cyril Montagne , Wolfgang Sauer , Stefano Crosignani , Agnes Bombrun , Mathilde Muzerelle , Jerome Dorbais , Delphine Marin , Jerome Gonzalez , Patrick Gerber
发明人： Anna Quattropani , Cyril Montagne , Wolfgang Sauer , Stefano Crosignani , Agnes Bombrun , Mathilde Muzerelle , Jerome Dorbais , Delphine Marin , Jerome Gonzalez , Patrick Gerber
IPC分类号： A61K31/5377 , C07D271/06 , C07D413/02 , A61K31/4245 , A61K31/4439 , A61K31/454
CPC分类号： C07D263/32 , C07D413/04 , C07D413/10
摘要： The invention relates to compounds of formula I: wherein R1, R2, Ra, Rb, W, Q and S have the meanings given in claim 16. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
摘要翻译： 本发明涉及式I化合物：其中R1，R2，Ra，Rb，W，Q和S具有权利要求16中给出的含义。 治疗自身免疫性疾病，如多发性硬化症。
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公开(公告)号：US08202856B2
公开(公告)日：2012-06-19
申请号：US12809816
申请日：2008-12-17
申请人： Anna Quattropani , Christophe Cleva , Eric Sebille , Matthias Schwarz , Delphine Marin , Agnes Bombrun , Wesley Blackaby , Charles Baker-Glenn , Chris Knight , Craig Rouse
发明人： Anna Quattropani , Christophe Cleva , Eric Sebille , Matthias Schwarz , Delphine Marin , Agnes Bombrun , Wesley Blackaby , Charles Baker-Glenn , Chris Knight , Craig Rouse
IPC分类号： A61K31/397 , A61K31/4545 , A61K31/444 , A61K31/5377 , A61K31/4245 , A61K31/4439 , A61K31/4725 , A61K31/497 , C07D413/04 , C07D413/14 , C07D401/14 , A61P19/02 , A61P3/10 , A61P9/10 , A61P29/00 , A61P1/04 , A61P17/06 , A61P11/06
CPC分类号： C07D413/04 , C07D413/14
摘要： The invention relates to compounds of formula I: wherein R1, R2,Ra, Rb, X have the meanings given in claim 16. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
摘要翻译： 本发明涉及式I化合物：其中R1，R2，Ra，Rb，X具有权利要求1中给出的含义。 治疗自身免疫性疾病，如多发性硬化症。
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公开(公告)号：US08247437B2
公开(公告)日：2012-08-21
申请号：US13155411
申请日：2011-06-08
申请人： Dominique Swinnen , Agnes Bombrun , Jerome Gonzalez , Stefano Crosignani , Patrick Gerber , Catherine Jorand-Lebrun
发明人： Dominique Swinnen , Agnes Bombrun , Jerome Gonzalez , Stefano Crosignani , Patrick Gerber , Catherine Jorand-Lebrun
IPC分类号： C07D211/70 , C07D405/06 , A61K31/4418
CPC分类号： C07D211/46 , C07D211/58 , C07D213/74 , C07D215/46 , C07D239/42 , C07D241/20 , C07D285/08 , C07D295/185 , C07D401/12 , C07D487/08
摘要： The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.
摘要翻译： 本发明涉及式（I）的N-羟基酰胺衍生物及其用途，特别是其用于治疗和/或预防自身免疫疾病，炎性疾病，心血管疾病，神经变性疾病，癌症，呼吸系统疾病和纤维化，包括多发性硬化症 ，关节炎，肺气肿，慢性阻塞性肺病，肝纤维化和肺纤维化。
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公开(公告)号：US20080021028A1
公开(公告)日：2008-01-24
申请号：US11572761
申请日：2005-07-25
申请人： Dominique Swinnen , Agnes Bombrun , Jerome Gonzalez , Stefano Crosignani , Patrick Gerber , Catherine Jorand-Lebrun
发明人： Dominique Swinnen , Agnes Bombrun , Jerome Gonzalez , Stefano Crosignani , Patrick Gerber , Catherine Jorand-Lebrun
IPC分类号： A61K31/445 , A61K31/4965 , A61K31/497 , A61K31/505 , A61K31/5375 , A61P29/00 , C07D211/04 , C07D239/02 , C07D401/02 , C07D403/02 , C07D413/02
CPC分类号： C07D211/46 , C07D211/58 , C07D213/74 , C07D215/46 , C07D239/42 , C07D241/20 , C07D285/08 , C07D295/185 , C07D401/12 , C07D487/08
摘要： The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof, in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.
摘要翻译： 本发明涉及式（I）的N-羟基酰胺衍生物及其用途，特别是用于治疗和/或预防自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，癌症，呼吸系统疾病和纤维化，包括多种 硬化症，关节炎，肺气肿，慢性阻塞性肺病，肝纤维化和肺纤维化。
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公开(公告)号：US20110263628A1
公开(公告)日：2011-10-27
申请号：US13155411
申请日：2011-06-08
申请人： Dominique Swinnen , Agnes Bombrun , Jerome Gonzalez , Stefano Crosignani , Patrick Gerber , Catherine Jorand-Lebrun
发明人： Dominique Swinnen , Agnes Bombrun , Jerome Gonzalez , Stefano Crosignani , Patrick Gerber , Catherine Jorand-Lebrun
IPC分类号： A61K31/4468 , C07D401/12 , C07D211/46 , C07D413/04 , C07D211/18 , A61K31/4545 , A61K31/445 , A61K31/506 , A61K31/454 , A61P29/00 , A61P25/28 , A61P9/00 , A61P35/00 , A61P15/06 , A61P11/00 , A61P11/06 , A61P1/16 , A61P1/18 , A61P17/00 , C07D211/58
CPC分类号： C07D211/46 , C07D211/58 , C07D213/74 , C07D215/46 , C07D239/42 , C07D241/20 , C07D285/08 , C07D295/185 , C07D401/12 , C07D487/08
摘要： The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.
摘要翻译： 本发明涉及式（I）的N-羟基酰胺衍生物及其用途，特别是其用于治疗和/或预防自身免疫疾病，炎性疾病，心血管疾病，神经变性疾病，癌症，呼吸系统疾病和纤维化，包括多发性硬化症 ，关节炎，肺气肿，慢性阻塞性肺病，肝纤维化和肺纤维化。
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公开(公告)号：US08008302B2
公开(公告)日：2011-08-30
申请号：US11572761
申请日：2005-07-25
申请人： Dominique Swinnen , Agnes Bombrun , Jerome Gonzalez , Stefano Crosignani , Patrick Gerber , Catherine Jorand-Lebrun
发明人： Dominique Swinnen , Agnes Bombrun , Jerome Gonzalez , Stefano Crosignani , Patrick Gerber , Catherine Jorand-Lebrun
IPC分类号： A61K31/496 , A61K31/506 , C07D213/75 , C07D215/46 , C07D271/07 , C07D285/08 , C07D295/185 , C07D317/34 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/10 , C07D405/12 , A61K31/454 , A61K31/4418 , C07D211/70 , C07D413/04 , C07D417/12 , C07D487/08
CPC分类号： C07D211/46 , C07D211/58 , C07D213/74 , C07D215/46 , C07D239/42 , C07D241/20 , C07D285/08 , C07D295/185 , C07D401/12 , C07D487/08
摘要： The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof, in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.
摘要翻译： 本发明涉及式（I）的N-羟基酰胺衍生物及其用途，特别是用于治疗和/或预防自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，癌症，呼吸系统疾病和纤维化，包括多种 硬化症，关节炎，肺气肿，慢性阻塞性肺病，肝纤维化和肺纤维化。
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公开(公告)号：US06770656B2
公开(公告)日：2004-08-03
申请号：US10182745
申请日：2002-12-26
申请人： Serge Halazy , Matthias Schwarz , Bruno Antonsson , Agnes Bombrun , Jean-Claude Martinou , Dennis Church
发明人： Serge Halazy , Matthias Schwarz , Bruno Antonsson , Agnes Bombrun , Jean-Claude Martinou , Dennis Church
IPC分类号： C07D21304
CPC分类号： C07D217/26 , C07B2200/07 , C07C237/22 , C07C2601/14 , C07D207/16 , C07D211/60 , C07D277/06
摘要： The present invention is related to substituted amine derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such amine derivatives of formula (I). Said substituted amine derivatives are efficient modulators, in particular inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel substituted amine derivatives as well as methods of their preparation.
摘要翻译： 本发明涉及特别用作药物活性化合物的取代胺衍生物，以及含有式（I）胺衍生物的药物制剂。 所述取代的胺衍生物是Bax功能和/或活化的有效调节剂，特别是抑制剂。 本发明还涉及新型取代的胺衍生物及其制备方法。
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